Entropic elasticity of lambda-phage DNA
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This article is published in Science.The article was published on 1994-09-09 and is currently open access. It has received 2089 citations till now.read more
Citations
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On the interpretation of force extension curves of single protein molecules
TL;DR: Monte Carlo simulations of unfolded polypeptide chains are used to examine the average distance between the ends of a polypePTide chain as a function of the force that pulls these ends apart.
Journal ArticleDOI
A single molecule assay to probe monovalent and multivalent bonds between hyaluronan and its key leukocyte receptor CD44 under force
TL;DR: A versatile method for analyzing the nanomechanics of GAG·protein interactions at the level of single GAG chains is established, which provides new molecular-level insight into the role of mechanical forces in the assembly and function of G AG-rich extracellular matrices.
Journal ArticleDOI
Single-molecule force spectroscopy reveals folding steps associated with hormone binding and activation of the glucocorticoid receptor
Thomas Suren,Daniel A. Rutz,Patrick Mößmer,Ulrich Merkel,Johannes Buchner,Johannes Buchner,Matthias Rief +6 more
TL;DR: A “lid” structure whose opening and closing is tightly coupled to hormone binding is identified, which forms the basis for understanding GR activation and its regulation by chaperone proteins.
Journal ArticleDOI
On the convexity of transversely isotropic chain network models
TL;DR: The basic concern of the present work is the systematic derivation of a new constitutive framework for transversely isotropic materials with a particular application to soft-tissue biomechanics, and it allows the material's principal axes to align progressively with the axes of principal strain.
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Mechanisms of self-organization for the collagen fibril lattice in the human cornea
Xi Cheng,Peter M. Pinsky +1 more
TL;DR: A striking result is that the electrostatic restoring forces alone are able to reproduce the image-based lattice distribution function for the human cornea, and thus dynamically maintain the short-range order of the lattice.
References
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Direct mechanical measurements of the elasticity of single DNA molecules by using magnetic beads
TL;DR: Deviations from the force curves predicted by the freely jointed chain model suggest that DNA has significant local curvature in solution, and the effect of bend-inducing cis-diamminedichloroplatinum (II) was large and supports the hypothesis of natural curvatures in DNA.
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Application of the method of phage T4 DNA ligase-catalyzed ring-closure to the study of DNA structure. II. NaCl-dependence of DNA flexibility and helical repeat.
TL;DR: It is demonstrated that it is possible to determine the molar cyclization factor jM from single ligation reactions in which both circular and linear dimer DNA species are formed concurrently from linear monomers.
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Polymer conformational statistics. III. Modified Gaussian models of stiff chains
M. Fixman,J. Kovac +1 more
TL;DR: In this article, a modified Gaussian probability for intrachain distances was used to account for polymer chain stiffness or excluded volume effects in non-Newtonian viscosity theory.