Entropic elasticity of lambda-phage DNA
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This article is published in Science.The article was published on 1994-09-09 and is currently open access. It has received 2089 citations till now.read more
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Journal ArticleDOI
Is DNA a Good Model Polymer
TL;DR: The results indicate that the commonly used model polymer λ-DNA does not exhibit "ideal" scaling, but exists in the middle of the transition to long-chain behavior, and conclude that typical DNA used in experiments are too short to serve as an accurate model of long- chain, universal polymer behavior.
Journal ArticleDOI
Deciphering Molecular Interactions of Native Membrane Proteins by Single-Molecule Force Spectroscopy
TL;DR: Single-molecule force spectroscopy has been used to detect and characterize different types of molecular interactions that occur between and within native membrane proteins, including how these interactions were established during folding of alpha-helical secondary structure elements into the native protein and how they changed with oligomerization, temperature, and mutations.
Journal ArticleDOI
Dna under high tension : overstretching, undertwisting, and relaxation dynamics
TL;DR: In this paper, it was shown that a double-stranded DNA increases in length if put under tension greater than 10 pN; beyond this point its conformation can no longer be described using an inextensible wormlike-chain model.
Book ChapterDOI
Collagen in Arterial Walls: Biomechanical Aspects
TL;DR: This chapter is written with an emphasis on the biomechanical role of collagen in normal and diseased arterial walls, its structural quantification and its consideration in material models including phenomena such as growth and remodeling.
Journal ArticleDOI
Mechanochemistry : targeted delivery of single molecules
Anne-Sophie Duwez,Stéphane Cuenot,Christine Jérôme,Sabine Gabriel,Robert Jérôme,Stefania Rapino,Francesco Zerbetto +6 more
TL;DR: The atomic force microscope (AFM), which has been used extensively to investigate the stretching of individual molecules, can deliver and immobilize single molecules, one at a time, on a surface.
References
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Journal ArticleDOI
Direct mechanical measurements of the elasticity of single DNA molecules by using magnetic beads
TL;DR: Deviations from the force curves predicted by the freely jointed chain model suggest that DNA has significant local curvature in solution, and the effect of bend-inducing cis-diamminedichloroplatinum (II) was large and supports the hypothesis of natural curvatures in DNA.
Journal ArticleDOI
Application of the method of phage T4 DNA ligase-catalyzed ring-closure to the study of DNA structure. II. NaCl-dependence of DNA flexibility and helical repeat.
TL;DR: It is demonstrated that it is possible to determine the molar cyclization factor jM from single ligation reactions in which both circular and linear dimer DNA species are formed concurrently from linear monomers.
Journal ArticleDOI
Polymer conformational statistics. III. Modified Gaussian models of stiff chains
M. Fixman,J. Kovac +1 more
TL;DR: In this article, a modified Gaussian probability for intrachain distances was used to account for polymer chain stiffness or excluded volume effects in non-Newtonian viscosity theory.