Entropic elasticity of lambda-phage DNA
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This article is published in Science.The article was published on 1994-09-09 and is currently open access. It has received 2089 citations till now.read more
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PEVK extension of human soleus muscle titin revealed by immunolabeling with the anti-titin antibody 9D10.
TL;DR: The anti-titin antibody 9D10 is a useful tool for investigating the extensible behavior of the PEVK segment in both skeletal and cardiac muscles.
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Probing Single Biomolecules with Atomic Force Microscopy
TL;DR: The current status of the imaging possibilities of AFM on RNA, IgG, and gold-labeled cell adhesion proteoglycans, as well as of measurements of intermolecular binding forces between biomolecules in order to investigate their molecular structure, function, and elasticity are described.
Journal ArticleDOI
Structural dynamics of E. coli single-stranded DNA binding protein reveal DNA wrapping and unwrapping pathways
TL;DR: This work uses single-molecule force and fluorescence spectroscopy to investigate E. coli SSB binding to ssDNA and constructs an energy landscape for the ssDNA-SSB complex, revealing that unwrapping energy costs increase the more ssDNA is unraveled.
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Magnetic Forces and DNA Mechanics in Multiplexed Magnetic Tweezers
TL;DR: This work systematically addresses challenges related to scaling of multiplexed magnetic tweezers towards high levels of parallelization where large numbers of molecules are addressed in the same amount of time required by a single-molecule measurement.
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Flexibility of type I collagen and mechanical property of connective tissue.
TL;DR: The flexibility and elastic modulus of gross connective tissue, the fascicle, the fiber and then the collagen molecule are compared based on the data available in the literature.
References
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Direct mechanical measurements of the elasticity of single DNA molecules by using magnetic beads
TL;DR: Deviations from the force curves predicted by the freely jointed chain model suggest that DNA has significant local curvature in solution, and the effect of bend-inducing cis-diamminedichloroplatinum (II) was large and supports the hypothesis of natural curvatures in DNA.
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Application of the method of phage T4 DNA ligase-catalyzed ring-closure to the study of DNA structure. II. NaCl-dependence of DNA flexibility and helical repeat.
TL;DR: It is demonstrated that it is possible to determine the molar cyclization factor jM from single ligation reactions in which both circular and linear dimer DNA species are formed concurrently from linear monomers.
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Polymer conformational statistics. III. Modified Gaussian models of stiff chains
M. Fixman,J. Kovac +1 more
TL;DR: In this article, a modified Gaussian probability for intrachain distances was used to account for polymer chain stiffness or excluded volume effects in non-Newtonian viscosity theory.