Entropic elasticity of lambda-phage DNA
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This article is published in Science.The article was published on 1994-09-09 and is currently open access. It has received 2089 citations till now.read more
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Section: The Elastic Vertebrate Muscle Protein Titin; Titin as a modular spring: emerging mechanisms for elasticity control by titinin cardiac physiology and pathophysiology
TL;DR: In this article, the molecular basis of titin's extensibility, how titin contribution to passive muscle stiffness may be adjusted, and how adjustment of Titin's stiffness may influence muscle contraction.
Journal ArticleDOI
Peptide transporter DtpA has two alternate conformations, one of which is promoted by inhibitor binding
Christian A. Bippes,Lin Ge,Marcel Meury,Daniel Harder,Zöhre Ucurum,Hannelore Daniel,Dimitrios Fotiadis,Daniel J. Müller +7 more
TL;DR: Inhibitor binding to the Escherichia coli PTR dipeptide and tripeptides permease A (DtpA), which shows substrate specificities similar to its human homolog hPEPT1, is characterized and it is suggested that Lys[Z-NO2]-Val interacts with discrete residues in TMH 2 that are important for ligand binding and substrate affinity.
Journal ArticleDOI
Physiological levels of salt and polyamines favor writhe and limit twist in DNA
TL;DR: Quantitative analysis of single molecule experiments show that adding either of two natural polyamines, spermine or spermidine, produced more compact plectonemes in DNA in physiological concentrations of monovalent salt, suggesting polyamines may limit the twist density by favoring writhe which maintains the B-form.
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Skeletal tissues as nanomaterials
Laurent Bozec,Michael A. Horton +1 more
TL;DR: The London Centre for Nanotechnology is using several of the tools of ‘hard’ nanotechnology—such as atomic force microscopy—to re-examine collagen structure with the longer term aim of using such information to design materials with appropriate physical attributes.
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Nanochannel-Confined TAMRA-Polypyrrole Stained DNA Stretching by Varying the Ionic Strength from Micromolar to Millimolar Concentrations.
Seonghyun Lee,Yelin Lee,Yongkyun Kim,Cong Wang,Jungyul Park,Gun Young Jung,Yeng-Long Chen,Rakwoo Chang,Shuji Ikeda,Hiroshi Sugiyama,Kyubong Jo +10 more
TL;DR: TAMRA-polypyrrole stained DNA was used to stain single DNA molecules to evaluate several polymer physics theories proposed by Odijk, de Gennes and recent papers to deal with these regimes and DNA stretching in nanochannels by varying the ionic strength.
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Direct mechanical measurements of the elasticity of single DNA molecules by using magnetic beads
TL;DR: Deviations from the force curves predicted by the freely jointed chain model suggest that DNA has significant local curvature in solution, and the effect of bend-inducing cis-diamminedichloroplatinum (II) was large and supports the hypothesis of natural curvatures in DNA.
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Application of the method of phage T4 DNA ligase-catalyzed ring-closure to the study of DNA structure. II. NaCl-dependence of DNA flexibility and helical repeat.
TL;DR: It is demonstrated that it is possible to determine the molar cyclization factor jM from single ligation reactions in which both circular and linear dimer DNA species are formed concurrently from linear monomers.
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Polymer conformational statistics. III. Modified Gaussian models of stiff chains
M. Fixman,J. Kovac +1 more
TL;DR: In this article, a modified Gaussian probability for intrachain distances was used to account for polymer chain stiffness or excluded volume effects in non-Newtonian viscosity theory.