Entropic elasticity of lambda-phage DNA
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This article is published in Science.The article was published on 1994-09-09 and is currently open access. It has received 2089 citations till now.read more
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Journal ArticleDOI
Conformational Plasticity of the Essential Membrane-associated Mannosyltransferase PimA from Mycobacteria
David Giganti,David Giganti,Jorge Alegre-Cebollada,Saioa Urresti,David Albesa-Jové,Ane Rodrigo-Unzueta,Natalia Comino,Michael Kachala,Sonia Lopez-Fernandez,Dmitri I. Svergun,Julio M. Fernandez,Marcelo E. Guerin,Marcelo E. Guerin +12 more
TL;DR: This work constitutes the first conformational study of a glycosyl transferase at the single molecule level and proposes a model wherein the conformational transitions are important for the mannosyltransferase to interact with the donor and acceptor substrates/membrane.
Journal ArticleDOI
Longest Relaxation Times of Double-Stranded and Single-Stranded DNA
TL;DR: In this article, the longest relaxation times of double and single-stranded lambda DNA (ds λ-DNA, ss λ -DNA) were studied by viscosity measurements in an oscillatory flow and by stress relaxation measurements.
Journal ArticleDOI
Extension in Flow of a DNA Molecule Tethered at One End
TL;DR: Measurements of extension of tethered single molecules in flow analyzed by the method described here seem to make an excellent method for determining the persistence length of individual molecules.
Journal ArticleDOI
Advances in the mechanical modeling of filamentous actin and its cross-linked networks on multiple scales
TL;DR: Microstructurally motivated continuum models of the networks provide insights into larger systems containing cross-linked actin networks, which are based on worm-like chain models for polymers.
Journal ArticleDOI
Unfolding dynamics of proteins under applied force.
D. Alastair Smith,David J. Brockwell,Rebecca C. Zinober,Anthony W. Blake,Godfrey S. Beddard,Peter D. Olmsted,Sheena E. Radford +6 more
TL;DR: Data is presented from experiments in which synthetic protein polymers designed to mimic naturally occurring polyproteins have been mechanically unfolded and it is shown that the two unfolding mechanisms are not the same, at least for the proteins studied here.
References
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Direct mechanical measurements of the elasticity of single DNA molecules by using magnetic beads
TL;DR: Deviations from the force curves predicted by the freely jointed chain model suggest that DNA has significant local curvature in solution, and the effect of bend-inducing cis-diamminedichloroplatinum (II) was large and supports the hypothesis of natural curvatures in DNA.
Journal ArticleDOI
Application of the method of phage T4 DNA ligase-catalyzed ring-closure to the study of DNA structure. II. NaCl-dependence of DNA flexibility and helical repeat.
TL;DR: It is demonstrated that it is possible to determine the molar cyclization factor jM from single ligation reactions in which both circular and linear dimer DNA species are formed concurrently from linear monomers.
Journal ArticleDOI
Polymer conformational statistics. III. Modified Gaussian models of stiff chains
M. Fixman,J. Kovac +1 more
TL;DR: In this article, a modified Gaussian probability for intrachain distances was used to account for polymer chain stiffness or excluded volume effects in non-Newtonian viscosity theory.