Enzyme Linked Immunosorbent Spot (ELISPOT) Assay for Interferon‐Gamma Independently Predicts Renal Function in Kidney Transplant Recipients
Donald E. Hricik,Victoria Rodriguez,Jocelyn Riley,Katherine Bryan,Magdalena Tary-Lehmann,Neil S. Greenspan,Cora Dejelo,James A. Schulak,Peter S. Heeger,Peter S. Heeger +9 more
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TLDR
Increased levels of early alloreactivity measured with this ELISPOT assay may serve as a surrogate for chronic allograft dysfunction and show an independent correlation between early cellular allore activity and long‐term renal function.About:
This article is published in American Journal of Transplantation.The article was published on 2003-07-01 and is currently open access. It has received 195 citations till now. The article focuses on the topics: ELISPOT & Cellular immunity.read more
Citations
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Deacetylase inhibition promotes the generation and function of regulatory T cells
Ran Tao,Edwin F. de Zoeten,Engin Ozkaynak,Chunxia Chen,Liqing Wang,Paige M. Porrett,Bin Li,Laurence A. Turka,Eric N. Olson,Mark I. Greene,Andrew D. Wells,Wayne W. Hancock +11 more
TL;DR: Administration of an HDAC inhibitor (HDACi) in vivo increased Foxp3 gene expression, as well as the production and suppressive function of regulatory T cells (Treg cells), and HDAC9 proved particularly important in regulatingFoxp3-dependent suppression.
Journal ArticleDOI
Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy : Second Consensus Report
Mercè Brunet,Teun van Gelder,Anders Åsberg,Vincent Haufroid,Vincent Haufroid,Dennis A. Hesselink,Loralie J. Langman,Florian Lemaitre,Pierre Marquet,Christoph Seger,Maria Shipkova,Alexander A. Vinks,Alexander A. Vinks,Pierre Wallemacq,Eberhard Wieland,Jean-Baptiste Woillard,Markus J. Barten,Klemens Budde,Helena Colom,Maja Theresa Dieterlen,Laure Elens,Kamisha L. Johnson-Davis,Paweł K. Kunicki,Iain MacPhee,Satohiro Masuda,Binu S. Mathew,Olga Millán,Tomoyuki Mizuno,Tomoyuki Mizuno,Dirk Jan A.R. Moes,Caroline Monchaud,Ofelia Noceti,Tomasz Pawinski,Nicolas Picard,Ron H.N. van Schaik,Claudia Sommerer,Nils Tore Vethe,Brenda C. M. de Winter,Uwe Christians,Stein Bergan +39 more
TL;DR: It is concluded that considerable advances in the different fields of tacrolimus monitoring have been achieved during this last decade, and the Expert Committee concludes that Continued efforts should focus on the opportunities to implement in clinical routine the combination of new standardized PK approaches with PG, and valid biomarkers to further personalize tacolimus therapy and to improve long-term outcomes for treated patients.
Journal ArticleDOI
KDIGO Clinical Practice Guideline on the evaluation and management of candidates for kidney transplantation
Steven J. Chadban,Curie Ahn,David A. Axelrod,Bethany J. Foster,Bertram L. Kasiske,Vijah Kher,Deepali Kumar,Rainer Oberbauer,Julio Pascual,Helen Pilmore,James R. Rodrigue,Dorry L. Segev,Neil S. Sheerin,Kathryn Tinckam,Germaine Wong,Gregory A. Knoll +15 more
TL;DR: The goal is to assist the clinical team to assimilate all data relevant to an individual, consider this within their local health context, and make an overall judgment on candidacy for transplantation.
Journal ArticleDOI
Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report.
Anat R. Tambur,Patricia Campbell,Frans H.J. Claas,Sandy Feng,Howard M. Gebel,Annette M. Jackson,Roslyn B. Mannon,Elaine F. Reed,Kathryn Tinckam,Medhat Askar,Anil Chandraker,Patricia P. Chang,Monica Colvin,Anthony J. Demetris,Joshua M. Diamond,Anne I. Dipchand,Robert L. Fairchild,Mandy L. Ford,John J. Friedewald,Ronald G. Gill,Denis Glotz,Hilary J. Goldberg,Ramsey R. Hachem,Stuart J. Knechtle,Jon A. Kobashigawa,Deborah Levine,J. Levitsky,Michael Mengel,Edgar L. Milford,Kenneth A. Newell,Jacqueline G. O'Leary,Scott M. Palmer,Parmjeet Randhawa,John D. Smith,Laurie D. Snyder,Randall C. Starling,Stuart C. Sweet,Timucin Taner,Craig J. Taylor,Steve Woodle,Adriana Zeevi,Peter Nickerson +41 more
TL;DR: Recommendations on the definition and utilization of HLA diagnostic testing, and a framework for clinical assessment of risk for a memory or a primary alloimmune response are provided, intended to spur research that will inform the next STAR Working Group meeting in 2019.
Journal ArticleDOI
Adverse Outcomes of Tacrolimus Withdrawal in Immune–Quiescent Kidney Transplant Recipients
Donald E. Hricik,Richard N. Formica,Peter Nickerson,David N. Rush,Robert L. Fairchild,Emilio D. Poggio,Ian W. Gibson,Chris Wiebe,Kathryn Tinckam,Suphamai Bunnapradist,Milagros Samaniego-Picota,Daniel C. Brennan,Bernd Schröppel,A. Osama Gaber,A. Osama Gaber,Brian Armstrong,David Ikle,Helena Diop,Nancy D. Bridges,Peter S. Heeger +19 more
TL;DR: Although data indicate that urinary CXCL9 monitoring, epitope mismatches, and ELISPOT assays are potentially informative, complete CNI withdrawal must be strongly discouraged in kidney transplant recipients who are receiving standard-of-care immunosuppression, including those who are deemed to be immunologically quiescent.
References
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Journal ArticleDOI
Improved Graft Survival after Renal Transplantation in the United States, 1988 to 1996
Sundaram Hariharan,Christopher P. Johnson,Barbara A. Bresnahan,S. Taranto,Matthew McIntosh,Donald Stablein +5 more
TL;DR: There has been a substantial increase in short-term and long-term survival of kidney grafts from both living and cadaveric donors since 1988.
Journal ArticleDOI
Post-transplant renal function in the first year predicts long-term kidney transplant survival
Sundaram Hariharan,Maureen A. McBride,Wida S. Cherikh,Christine B. Tolleris,Barbara A. Bresnahan,Christopher P. Johnson +5 more
TL;DR: Recent improvements in graft half-life are related to conservation of renal function within the first year post-transplantation, and one-year creatinine and Delta Creatinine values predict long-term renal graft survival.
Journal ArticleDOI
Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine.
Baogui Li,Choli Hartono,Ruchuang Ding,Vivek Sharma,Ravi Ramaswamy,Biao Qian,David Serur,Janet Mouradian,Joseph E. Schwartz,Manikkam Suthanthiran +9 more
TL;DR: Measurement of mRNA encoding cytotoxic proteins in urinary cells offers a noninvasive means of diagnosing acute rejection of renal allografts and identified those in whom acute rejection developed.
Journal Article
Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes.
Peter S. Heeger,Neil S. Greenspan,Shannon Kuhlenschmidt,Cora Dejelo,Donald E. Hricik,James A. Schulak,Magdalena Tary-Lehmann +6 more
TL;DR: Improved ability to define the strength of the allospecific immune response by enzyme-linked immunospot assay may allow improved pairing of recipients with donors and identification of kidney allograft donor-recipient pairs at high risk for acute rejection, thus permitting targeted interventions aimed at prolonging graft survival.
Journal ArticleDOI
Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts.
Rodica Ciubotariu,Zhuoru Liu,Adriana I. Colovai,Eric K. Ho,Silviu Itescu,S Ravalli,M. A. Hardy,Raffaello Cortesini,Eric A. Rose,Nicole Suciu-Foca +9 more
TL;DR: Data provide a strategy for identifying patients at risk of developing CAV and a rationale for therapeutic intervention aimed to prevent the progression of the rejection process, and suggest that diversification of the immune response against the graft contributes to chronic rejection.