Journal ArticleDOI
Epigenetic events in mammalian germ-cell development: reprogramming and beyond
Hiroyuki Sasaki,Yasuhisa Matsui +1 more
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TLDR
It is shown that epigenetic modifiers have key roles in germ-cell development itself and contributes to the gene-expression programme that is required for germ- cell development, regulation of meiosis and genomic integrity.Abstract:
The epigenetic profile of germ cells, which is defined by modifications of DNA and chromatin, changes dynamically during their development. Many of the changes are associated with the acquisition of the capacity to support post-fertilization development. Our knowledge of this aspect has greatly increased- for example, insights into how the re-establishment of parental imprints is regulated. In addition, an emerging theme from recent studies is that epigenetic modifiers have key roles in germ-cell development itself--for example, epigenetics contributes to the gene-expression programme that is required for germ-cell development, regulation of meiosis and genomic integrity. Understanding epigenetic regulation in germ cells has implications for reproductive engineering technologies and human health.read more
Citations
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Influence of intergenerational in utero parental energy and nutrient restriction on offspring growth in rural Gambia.
Kamilla G. Eriksen,Elizabeth J. Radford,Matt J. Silver,Matt J. Silver,Anthony J. C. Fulford,Anthony J. C. Fulford,Rita Wegmüller,Andrew M. Prentice,Andrew M. Prentice +8 more
TL;DR: It is found that maternal exposure to seasonal energy restriction in utero was associated with reduced offspring birth length and periods of nutritional restriction in a parent's fetal life can have intergenerational consequences in human populations.
Journal ArticleDOI
Tracing the conversion process from primordial germ cells to pluripotent stem cells in mice
Go Nagamatsu,Takeo Kosaka,Shigeru Saito,Keiyo Takubo,Hideo Akiyama,Tetsuo Sudo,Katsuhisa Horimoto,Katsuhisa Horimoto,Mototsugu Oya,Toshio Suda +9 more
TL;DR: The overall gene expression profiles revealed by this system provide novel insight into how pluripotency is acquired in germ-committed cells.
Journal ArticleDOI
Differentiation of Human Parthenogenetic Pluripotent Stem Cells Reveals Multiple Tissue- and Isoform-Specific Imprinted Transcripts
Yonatan Stelzer,Yonatan Stelzer,Shiran Bar,Osnat Bartok,Shaked Afik,Daniel Ronen,Sebastian Kadener,Nissim Benvenisty +7 more
TL;DR: This study provides a global analysis of tissue-specific imprinting in humans and suggests that alternative promoters are central in the regulation of imprinted genes.
Journal ArticleDOI
piRNA- and siRNA-mediated transcriptional repression in Drosophila, mice, and yeast: new insights and biodiversity
TL;DR: In this article, the authors summarize the recent progress regarding piRNA-mediated transcriptional silencing in Drosophila and discuss the biodiversity by comparing it with the equivalent siRNA mediated system in mice and the siRNA-medicated system in fission yeast.
Journal ArticleDOI
Mechanisms of epigenetic remodelling during preimplantation development.
Pablo J. Ross,Sebastian Canovas +1 more
TL;DR: An understanding of the mechanisms of epigenetic remodelling during early embryo development is important to assess the potential for gametic epigenetic mutations to contribute to the offspring and for new epimutations to be established during embryo manipulations that could affect a large number of cells in the offspring.
References
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Journal ArticleDOI
A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells
Bradley E. Bernstein,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Xiaohui Xie,Michael Kamal,Dana J. Huebert,James Cuff,Ben Fry,Alexander Meissner,Marius Wernig,Kathrin Plath,Rudolf Jaenisch,Alexandre Wagschal,Robert Feil,Stuart L. Schreiber,Stuart L. Schreiber,Eric S. Lander,Eric S. Lander +17 more
TL;DR: It is proposed that bivalent domains silence developmental genes in ES cells while keeping them poised for activation, highlighting the importance of DNA sequence in defining the initial epigenetic landscape and suggesting a novel chromatin-based mechanism for maintaining pluripotency.
Journal ArticleDOI
Generation of germline-competent induced pluripotent stem cells
TL;DR: iPS cells competent for germline chimaeras can be obtained from fibroblasts, but retroviral introduction of c-Myc should be avoided for clinical application.
Journal ArticleDOI
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
Marius Wernig,Alexander Meissner,Ruth K. Foreman,Tobias Brambrink,Manching Ku,Konrad Hochedlinger,Konrad Hochedlinger,Bradley E. Bernstein,Bradley E. Bernstein,Rudolf Jaenisch +9 more
TL;DR: The results show that the biological potency and epigenetic state of in-vitro-reprogrammed induced pluripotent stem cells are indistinguishable from those of ES cells.
Journal ArticleDOI
Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility
TL;DR: The ability of an environmental factor to reprogram the germ line and to promote a transgenerational disease state has significant implications for evolutionary biology and disease etiology.
Journal ArticleDOI
Environmental epigenomics and disease susceptibility.
TL;DR: An increasing body of evidence from animal studies supports the role of environmental epigenetics in disease susceptibility and recent studies have demonstrated for the first time that heritable environmentally induced epigenetic modifications underlie reversible transgenerational alterations in phenotype.
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