Estrogen-Related Receptor α Directs Peroxisome Proliferator-Activated Receptor α Signaling in the Transcriptional Control of Energy Metabolism in Cardiac and Skeletal Muscle
TLDR
It is concluded that ERRα serves as a critical nodal point in the regulatory circuitry downstream of PGC-1α to direct the transcription of genes involved in mitochondrial energy-producing pathways in cardiac and skeletal muscle.Citations
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Metabolic control through the PGC-1 family of transcription coactivators.
TL;DR: This work has shown that the PGC-1 coactivators play a critical role in the maintenance of glucose, lipid, and energy homeostasis and are likely involved in the pathogenic conditions such as obesity, diabetes, neurodegeneration, and cardiomyopathy.
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Myocardial Substrate Metabolism in the Normal and Failing Heart
TL;DR: This review discusses the metabolic changes that occur in chronic heart failure, with emphasis on the mechanisms that regulate the changes in the expression of metabolic genes and the function of metabolic pathways and the consequences of these metabolic changes on cardiac function.
Journal ArticleDOI
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Zoltan Arany,Shi-Yin Foo,Yanhong Ma,Jorge L. Ruas,Archana Bommi-Reddy,Geoffrey D. Girnun,Marcus P. Cooper,Dina Laznik,Jessica Chinsomboon,Shamina M. Rangwala,Kwan-Hyuck Baek,Anthony Rosenzweig,Bruce M. Spiegelman +12 more
TL;DR: PGC-1α and ERR-α, major regulators of mitochondrial function in response to exercise and other stimuli, also control a novel angiogenic pathway that delivers needed oxygen and substrates, and may provide a novel therapeutic target for treating ischaemic diseases.
Journal ArticleDOI
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors
Liliane Michalik,Johan Auwerx,Joel P. Berger,V. Krishna K. Chatterjee,Christopher K. Glass,Frank J. Gonzalez,Paul Grimaldi,Takashi Kadowaki,Mitchell A. Lazar,Stephen O'Rahilly,Colin N. A. Palmer,Jorge Plutzky,Janardan K. Reddy,Bruce M. Spiegelman,Bart Staels,Walter Wahli +15 more
TL;DR: The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of the nuclear hormone receptor superfamily as discussed by the authors, which share a high degree of structural homology with all members of the superfamily, particularly in the DNA-binding domain and ligand and cofactor binding domain.
Journal ArticleDOI
PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.
Teresa C. Leone,John J. Lehman,Brian N. Finck,Paul J. Schaeffer,Adam R. Wende,Sihem Boudina,Michael Courtois,David F. Wozniak,Nandakumar Sambandam,Carlos Bernal-Mizrachi,Zhouji Chen,John O. Holloszy,Denis M. Medeiros,Robert E. Schmidt,Jeffrey E. Saffitz,E. Dale Abel,Clay F. Semenkovich,Daniel P. Kelly +17 more
TL;DR: It is demonstrated that PGC-1α is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life.
References
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Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1
Zhidan Wu,Pere Puigserver,Ulf Andersson,Chen-Yu Zhang,Guillaume Adelmant,Vamsi K. Mootha,Amy E Troy,Saverio Cinti,Bradford B. Lowell,Richard C. Scarpulla,Bruce M. Spiegelman +10 more
TL;DR: PGC-1, a cold-inducible coactivator of nuclear receptors, stimulates mitochondrial biogenesis and respiration in muscle cells through an induction of uncoupling protein 2 (UCP-2) and through regulation of the nuclear respiratory factors (NRFs).
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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
Pere Puigserver,Zhidan Wu,Cheol Won Park,Reed A. Graves,Margaret E. Wright,Bruce M. Spiegelman +5 more
TL;DR: Results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis.
PatentDOI
A simplified system for generating recombinant adenoviruses
TL;DR: In this paper, a recombinant adenoviral plasmid is generated with a minimum of enzymatic manipulations, employing homologous recombination in bacteria rather than in eucaryotic cells.
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Peroxisome proliferator-activated receptors: nuclear control of metabolism.
Béatrice Desvergne,Walter Wahli +1 more
TL;DR: This work has shown that direct expression of PPAR mRNAs in the absence of a specific carrier gene results in down-regulation in the activity of other PPARs, and these properties are consistent with those of a “spatially aggregating substance”.
Journal ArticleDOI
Nuclear receptors and lipid physiology: opening the X-files.
TL;DR: Some general principles that govern the actions of this class of bioactive lipids and their nuclear receptors are considered here, and the scheme that emerges reveals a complex molecular script at work.