Journal ArticleDOI
Evolutionary Origins of cGAS-STING Signaling
TLDR
The evolutionary origins of the cGAS-STING pathway are discussed, and the possibility that the ancestral functions of STING may have included activation of antibacterial immunity is considered.About:
This article is published in Trends in Immunology.The article was published on 2017-10-01. It has received 187 citations till now. The article focuses on the topics: Sting.read more
Citations
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Blocking cGAS/STING signaling protects against sepsis-associated acute liver injury.
Jie Liu,Yanyan Lu,Ge Lin +2 more
TL;DR: In this article , the role of cyclic GMPAMP synthase (cGAS) in the development of acute liver injury (ALI) was investigated, and if any, by which mechanism cGAS is involved.
Journal ArticleDOI
cGAS-STING Pathway as the Target of Immunotherapy for Lung Cancer
Hong Ge,Qinfu Dan,Yang Yang +2 more
TL;DR: In this article , a review of the biological function, activation mode, and current applications of the cyclical GMP-AMP synthetase pathway in lung cancer therapy is presented.
Journal ArticleDOI
Identification of Ziyuglycoside II from a Natural Products Library as a STING Agonist
TL;DR: A small‐molecular STING agonist, Ziyuglycoside II, termed ST12, with potent stimulation of the IRF/IFN and NF‐κB pathways is identified and its binding to the C‐terminal domain of human STING, detected by bio‐layer interferometry, indicates that ST12 is a human STing agonist.
Journal ArticleDOI
Inhibition of cGAS ameliorates acute lung injury triggered by zinc oxide nanoparticles.
Ziqi Jiang,Yu Jiang,Jingchuan Fan,Jun Zhang,Ge Xu,Yinzhen Fan,Liyu Zhang,Xia Qin,Xuejun Jiang,Lejiao Mao,Gang Liu,Chengzhi Chen,Zhen-Xing Zou +12 more
TL;DR: In this article , the role and mechanism of the cGAS-STING pathway in ALI-induced by ZnONPs are investigated, and the authors demonstrated that ZnonPs trigger the activation of the CGMP-AMP synthase and stimulator of interferon genes (STING) pathway.
Journal ArticleDOI
Classes of therapeutics to amplify the immune response.
Yang Hu,Mark E. Burkard +1 more
TL;DR: In this paper, the mechanisms of existing strategies including chemotherapies and how they may cause breast cancers to become immunogenic to identify potential biomarkers for combinations of conventional and immunotherapy.
References
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Journal ArticleDOI
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
TL;DR: Results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP, which belongs to the nucleotidyltransferase family.
Journal ArticleDOI
Autophagy in immunity and inflammation
TL;DR: A crucial role is revealed for the autophagy pathway and proteins in immunity and inflammation, and they balance the beneficial and detrimental effects of immunity andinflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.
Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TL;DR: Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
Journal ArticleDOI
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more
TL;DR: The identification of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes is reported, implying a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA.
Journal ArticleDOI
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
TL;DR: It is shown that STING (stimulator of interferon genes) is critical for the induction of IFN by non-CpG intracellular DNA species produced by various DNA pathogens after infection.
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Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
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