Journal ArticleDOI
Evolutionary Origins of cGAS-STING Signaling
TLDR
The evolutionary origins of the cGAS-STING pathway are discussed, and the possibility that the ancestral functions of STING may have included activation of antibacterial immunity is considered.About:
This article is published in Trends in Immunology.The article was published on 2017-10-01. It has received 187 citations till now. The article focuses on the topics: Sting.read more
Citations
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Bacteriophages antagonize cGAS-like immunity in bacteria
Erin D Huiting,Januka S Athukoralage,J. Guan,Sukrit Silas,Heloise Carion,Joseph Bondy-Denomy +5 more
TL;DR: A native model system is established to study CBASS and a common phage-encoded CBASS antagonist is identified, demonstrating that CBASS is a bona fide anti-phage immune system in nature.
Journal ArticleDOI
Interference on Cytosolic DNA Activation Attenuates Sepsis Severity: Experiments on Cyclic GMP-AMP Synthase (cGAS) Deficient Mice.
Peerapat Visitchanakun,Warerat Kaewduangduen,Awirut Chareonsappakit,Paweena Susantitaphong,Prapaporn Pisitkun,Patcharee Ritprajak,Natavudh Townamchai,Asada Leelahavanichkul +7 more
TL;DR: In this article, the influence of the cytosolic DNA receptor cGAS (cyclic guanosine monophosphate-adenosine monphosphate (GMP-AMP) synthase) on sepsis is investigated.
Posted ContentDOI
STING mediates immune responses in a unicellular choanoflagellate
TL;DR: In this paper, the authors developed the choanoflagellate Monosiga brevicollis, one of the closest living relatives of animals, as a model for studying mechanisms underlying pathogen recognition and immune response.
Journal ArticleDOI
Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence
TL;DR: In this paper , the authors showed that the phage protein Vs.4 antagonized cGAS signalling by binding tightly to cGAMP (dissociation constant of approximately 30 nM) and sequestering it.
Journal ArticleDOI
TLR9 in MAFLD and NASH: At the Intersection of Inflammation and Metabolism.
TL;DR: Toll-like Receptor 9 (TLR9) is an ancient receptor integral to the primordial functions of inflammation and metabolism and it functions to regulate homeostasis in a healthy system under acute stress.
References
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Journal ArticleDOI
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
TL;DR: Results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP, which belongs to the nucleotidyltransferase family.
Journal ArticleDOI
Autophagy in immunity and inflammation
TL;DR: A crucial role is revealed for the autophagy pathway and proteins in immunity and inflammation, and they balance the beneficial and detrimental effects of immunity andinflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.
Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TL;DR: Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
Journal ArticleDOI
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more
TL;DR: The identification of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes is reported, implying a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA.
Journal ArticleDOI
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
TL;DR: It is shown that STING (stimulator of interferon genes) is critical for the induction of IFN by non-CpG intracellular DNA species produced by various DNA pathogens after infection.
Related Papers (5)
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more