Journal ArticleDOI
Evolutionary Origins of cGAS-STING Signaling
TLDR
The evolutionary origins of the cGAS-STING pathway are discussed, and the possibility that the ancestral functions of STING may have included activation of antibacterial immunity is considered.About:
This article is published in Trends in Immunology.The article was published on 2017-10-01. It has received 187 citations till now. The article focuses on the topics: Sting.read more
Citations
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Journal ArticleDOI
cGAS in action: Expanding roles in immunity and inflammation
Andrea Ablasser,Zhijian J. Chen +1 more
TL;DR: The latest advances uncovering how cGAS and STING control inflammatory responses and are themselves regulated are reviewed, suggesting a major clinical impact in areas of cancer immunotherapy and vaccine development.
Journal ArticleDOI
The cGAS-STING pathway as a therapeutic target in inflammatory diseases.
TL;DR: The cGAS-STING pathway has emerged as a key mediator of inflammation in the settings of infection, cellular stress and tissue damage as discussed by the authors, which has enabled the development of selective small-molecule inhibitors with the potential to target the CGS-STing axis in a number of inflammatory diseases.
Journal ArticleDOI
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3
Moritz M. Gaidt,Thomas S. Ebert,Dhruv Chauhan,Katharina Ramshorn,Francesca Pinci,Sarah Zuber,Fionan O’Duill,Jonathan L. Schmid-Burgk,Florian Hoss,Raymund Buhmann,Georg Wittmann,Eicke Latz,Eicke Latz,Marion Subklewe,Veit Hornung +14 more
TL;DR: It is shown that AIM2 is dispensable for DNA-mediated inflammasome activation in human myeloid cells, and targeting the cGAS-STING-LCD-NLRP3 pathway will ameliorate pathology in inflammatory conditions that are associated with cytosolic DNA sensing.
Journal ArticleDOI
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Haipeng Liu,Haiping Zhang,Xiangyang Wu,Dapeng Ma,Juehui Wu,Lin Wang,Yan Jiang,Yiyan Fei,Chenggang Zhu,Rong Tan,Peter R. Jungblut,Gang Pei,Anca Dorhoi,Anca Dorhoi,Qiaoling Yan,Fan Zhang,Ruijuan Zheng,Siyu Liu,Haijiao Liang,Zhonghua Liu,Hua Yang,Jianxia Chen,Peng Wang,Tianqi Tang,Wenxia Peng,Zhangsen Hu,Zhu Xu,Xiaochen Huang,Jie Wang,Haohao Li,Yilong Zhou,Feng Liu,Dapeng Yan,Stefan H. E. Kaufmann,Chang Chen,Zhiyong Mao,Baoxue Ge +36 more
TL;DR: It is concluded that nuclear cGAS suppresses homologous-recombination-mediated repair and promotes tumour growth, and that cGas therefore represents a potential target for cancer prevention and therapy.
Journal ArticleDOI
Cyclic GMP-AMP signalling protects bacteria against viral infection.
Daniel Cohen,Sarah Melamed,Adi Millman,Gabriela Shulman,Yaara Oppenheimer-Shaanan,Assaf Kacen,Shany Doron,Gil Amitai,Rotem Sorek +8 more
TL;DR: cGAMP signalling in bacteria mediates anti-phage defence, as part of a genetic system suggested to be the ancient ancestor of the animal cGAS–STING innate immune pathway.
References
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Journal ArticleDOI
Characterization of the core elements of the NF-κB signaling pathway of the sea anemone Nematostella vectensis.
Francis S. Wolenski,Michael R. Garbati,Tristan J. Lubinski,Nikki Traylor-Knowles,Erica C. Dresselhaus,Derek J. Stefanik,Haley Goucher,John R. Finnerty,Thomas D. Gilmore +8 more
TL;DR: The results indicate that NF-κB pathway proteins in Nematostella are similar to their vertebrate homologs, and these results also provide a framework for understanding the evolutionary origins of NF-σκB signaling.
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Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates
Deyu Zhu,Lijun Wang,Guijun Shang,Xue Liu,Jing Zhu,Defen Lu,Lei Wang,Biao Kan,Jing-Ren Zhang,Ye Xiang +9 more
TL;DR: Sequence analysis showed that the residues involved in 5MTHFGLU2 binding are highly conserved in DncV orthologs, implying the presence of this regulation mechanism in a wide variety of bacteria.
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Listeria monocytogenes Multidrug Resistance Transporters and Cyclic Di-AMP, Which Contribute to Type I Interferon Induction, Play a Role in Cell Wall Stress
Millie Kaplan Zeevi,Nirit S. Shafir,Shira Shaham,Sivan Friedman,Nadejda Sigal,Ran Nir Paz,Ivo G. Boneca,Ivo G. Boneca,Anat A. Herskovits +8 more
TL;DR: It is reported that it is not MdrM alone but a cohort of MDR transporters that together contribute to type I interferon induction during infection and support the model that MDRtransporters mediate c-di-AMP secretion to regulate peptidoglycan synthesis in response to cell wall stress.
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Nucleic acid-induced antiviral immunity in invertebrates: An evolutionary perspective
TL;DR: The current understanding of nucleic acid-induced antiviral immunity in invertebrates is highlighted and the potential recognition and regulatory mechanisms that confer non-specific antiviral immune responses on invertebrate hosts are discussed.
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Intronless and intron-containing type I IFN genes coexist in amphibian Xenopus tropicalis: Insights into the origin and evolution of type I IFNs in vertebrates.
TL;DR: This study contributes to a better understanding of the origin and evolution of type I IFNs in vertebrates, and of the occurrence of intronless and intron‐containingtype I IFN genes in higher vertebrates.
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