Journal ArticleDOI
Evolutionary Origins of cGAS-STING Signaling
TLDR
The evolutionary origins of the cGAS-STING pathway are discussed, and the possibility that the ancestral functions of STING may have included activation of antibacterial immunity is considered.About:
This article is published in Trends in Immunology.The article was published on 2017-10-01. It has received 187 citations till now. The article focuses on the topics: Sting.read more
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PARP and PI3K inhibitor combination therapy eradicates c-MYC-driven murine prostate cancers via cGAS/STING pathway activation within tumor-associated macrophages
Priyanka Dutta Gupta,Kiranj K. Chaudagar,Sweta Sharma-Saha,Kaela Bynoe,Lea Maillat,Brian L. Heiss,Walter M. Stadler,Akash Patnaik +7 more
TL;DR: It is demonstrated that PARPi/PI3Ki combination triggers macrophage STING-mediated anti-cancer innate immunity, which is sufficient to induce tumor regression in ICB-refractory c-myc-driven prostate cancer.
Journal ArticleDOI
cGAS promotes sepsis in radiotherapy of cancer by up-regulating caspase-11 signaling.
Ming Wu,Jian Shi,Shasha He,Di Wang,Na Zhang,Zhigan Wang,Fanfan Yang,Jun He,Danping Hu,Xinyu Yang,Chuang Yuan,Chuang Yuan +11 more
TL;DR: In this article, the effects of radiation-enhanced caspase-11 pathway on lung injury and mortality in the sepsis model were investigated in mice deficient to cGas, Caspase11, GSDMD, or Asc.
Journal ArticleDOI
The antiviral role of NF-κB-mediated immune responses and their antagonism by viruses in insects.
TL;DR: The increasing number of known molecular mechanisms by which viruses antagonise NF-κB responses are summarized, which suggest that NF-σκB-mediated immunity exerts strong evolutionary pressures on viruses.
Journal ArticleDOI
Bacterial twist to an antiviral defence
TL;DR: The discovery of an antiviral defence system in bacteria that shares some components with a key antiviral Defence pathway in animals provides insight into how this important response might have evolved.
Journal ArticleDOI
The cGAS-STING-autophagy pathway: Novel perspectives in neurotoxicity induced by manganese exposure.
Xin Zhang,Jingjing Liu,Hui Wang +2 more
TL;DR: In this paper , the mechanism of neurotoxicity induced by manganese exposure from the cGAS-STING-autophagy pathway was discussed, and it was shown that Mn2+ is the second activator of the cGCAS-sting pathway besides dsDNA, and inducing autophagy is a primitive function for the activation of the CGCASSTING pathway.
References
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Journal ArticleDOI
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
TL;DR: Results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP, which belongs to the nucleotidyltransferase family.
Journal ArticleDOI
Autophagy in immunity and inflammation
TL;DR: A crucial role is revealed for the autophagy pathway and proteins in immunity and inflammation, and they balance the beneficial and detrimental effects of immunity andinflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.
Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TL;DR: Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
Journal ArticleDOI
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more
TL;DR: The identification of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes is reported, implying a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA.
Journal ArticleDOI
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
TL;DR: It is shown that STING (stimulator of interferon genes) is critical for the induction of IFN by non-CpG intracellular DNA species produced by various DNA pathogens after infection.
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Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more