Journal ArticleDOI
Evolutionary Origins of cGAS-STING Signaling
TLDR
The evolutionary origins of the cGAS-STING pathway are discussed, and the possibility that the ancestral functions of STING may have included activation of antibacterial immunity is considered.About:
This article is published in Trends in Immunology.The article was published on 2017-10-01. It has received 187 citations till now. The article focuses on the topics: Sting.read more
Citations
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STING controls Herpes Simplex Virus in vivo independent of type I interferon induction
Lívia H. Yamashiro,Lívia H. Yamashiro,Stephen C. Wilson,Stephen C. Wilson,Huntly M. Morrison,Vasiliki Karalis,Jing-Yi J. Chung,Katherine J. Chen,Helen S. Bateup,Helen S. Bateup,Moriah L. Szpara,Angus Y. Lee,Jeffery S. Cox,Russell E. Vance +13 more
TL;DR: Interestingly, STING-induced autophagy is a TBK1-dependent IRF3-independent process that is conserved in the STING S365A mice, andAutophagy has previously been shown to be required for resistance to HSV-1.
Journal ArticleDOI
Type-1 interferon-dependent and -independent mechanisms in cyclic GMP-AMP synthase-stimulator of interferon genes-driven auto-inflammation.
TL;DR: In this paper , animal models have demonstrated that T1IFNs contribute to only some disease outcomes and that cGAS-STING activation also promotes T1ifN-independent pathology.
Journal ArticleDOI
cGAS-like receptor-mediated immunity: the insect perspective.
TL;DR: The cGAS-STING pathway plays a central role in the detection of DNA in the cytosol of mammalian cells and activation of immunity in invertebrates as mentioned in this paper .
Journal ArticleDOI
Insights on the cGAS-STING Signaling Pathway During Herpesvirus Infections
Lishuang Deng,Zhi Wen Xu,Fengqin Li,Jun Zhao,Zhijie Jian,Huidan Deng,Siyuan Lai,Xiangang Sun,Yi Geng,Ling Zhu +9 more
TL;DR: The activation of cGAS-STING signaling pathway during herpesvirus infections and strategies of herpesv virus targeting this pathway to evade host antiviral response are described.
Posted ContentDOI
ERR agonism reverses mitochondrial dysfunction and inflammation in the aging kidney
Xiaoxin X. Wang,Shogo Takahashi,Andrew E. Libby,Komuraiah Myakala,Bryce A. Jones,Kanchan Bhasin,Yue Qi,Kristopher W. Krausz,Patricia M. Zerfas,Julia Panov,Thomas J. Velenosi,Daxesh P. Patel,Parnaz Daneshpajouhnejad,Brandon Ginley,Pinaki Sarder,Avi Titievsky,Vadim V. Sharov,B. Ostretsov,Jeffrey B. Kopp,Avi Z. Rosenberg,Frank J. Gonzalez,Udayan Guha,Leonid Brodsky,Thomas P. Burris,Moshe Levi +24 more
TL;DR: In this paper, the role of the nuclear hormone receptors, the estrogen related receptors (ERRs) in regulation of age-related mitochondrial dysfunction and inflammation was studied in mice with lifelong caloric restriction.
References
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Journal ArticleDOI
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
TL;DR: Results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP, which belongs to the nucleotidyltransferase family.
Journal ArticleDOI
Autophagy in immunity and inflammation
TL;DR: A crucial role is revealed for the autophagy pathway and proteins in immunity and inflammation, and they balance the beneficial and detrimental effects of immunity andinflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.
Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TL;DR: Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
Journal ArticleDOI
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more
TL;DR: The identification of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes is reported, implying a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA.
Journal ArticleDOI
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
TL;DR: It is shown that STING (stimulator of interferon genes) is critical for the induction of IFN by non-CpG intracellular DNA species produced by various DNA pathogens after infection.
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Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
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