Journal ArticleDOI
Evolutionary Origins of cGAS-STING Signaling
TLDR
The evolutionary origins of the cGAS-STING pathway are discussed, and the possibility that the ancestral functions of STING may have included activation of antibacterial immunity is considered.About:
This article is published in Trends in Immunology.The article was published on 2017-10-01. It has received 187 citations till now. The article focuses on the topics: Sting.read more
Citations
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Comparison of Host Gene Expression Profiles in Spleen Tissues of Genetically Susceptible and Resistant Mice during ECTV Infection.
Wenyu Cheng,Huaijie Jia,Xiaobing He,Guohua Chen,Yuan Feng,Chun-Yan Wang,Xiaoxia Wang,Jing Zhizhong +7 more
TL;DR: Collectively, the differential transcriptome profiles of susceptible and resistant mouse strains with ECTV infection will be crucial for further uncovering the molecular mechanisms of the host-Orthopoxvirus interaction.
Journal ArticleDOI
No Longer A One-Trick Pony: STING Signaling Activity Beyond Interferon.
Jianjun Wu,Ridha Wahyuni,Nan Yan +2 more
TL;DR: In this article, the evolutionary origin and molecular mechanisms of STING-mediated type I interferon (IFN)independent activities were reviewed. But, the authors did not consider the effect of the environment on STING.
Journal ArticleDOI
No Longer A One-Trick Pony: STING Signaling Activity Beyond Interferon
TL;DR: In this article , the evolutionary origin and molecular mechanisms of STING-mediated type I interferon (IFN)independent activities were reviewed. But, the authors did not consider the effect of the environment on STING.
Journal ArticleDOI
Secretion of c-di-AMP by Listeria monocytogenes Leads to a STING-Dependent Antibacterial Response during Enterocolitis
TL;DR: These studies suggest that in barrier sites such as the intestinal tract, where pathogen-associated molecular patterns are abundant, cytosolic surveillance systems such as STING are well positioned to detect pathogenic bacteria.
Journal ArticleDOI
AMICA1 is a diagnostic and prognostic biomarker and induces immune cells infiltration by activating cGAS-STING signaling in lung adenocarcinoma
Ziyang Feng,Yan Bo Zhang,Min He,Ying Han,Changjing Cai,Shanshan Liu,Ping-ping Liu,Yilong Chen,Hong-Bin Shen,Shan Zeng +9 more
TL;DR: In this article , the role of AMICA1 in lung adenocarcinoma (LUAD) through bioinformatic analysis and in vitro experiments was investigated and it was shown that AMICA 1 might function as a diagnostic and prognostic biomarker and significantly suppressed the proliferation of LUAD cells.
References
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Journal ArticleDOI
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
TL;DR: Results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP, which belongs to the nucleotidyltransferase family.
Journal ArticleDOI
Autophagy in immunity and inflammation
TL;DR: A crucial role is revealed for the autophagy pathway and proteins in immunity and inflammation, and they balance the beneficial and detrimental effects of immunity andinflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.
Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TL;DR: Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
Journal ArticleDOI
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more
TL;DR: The identification of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes is reported, implying a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA.
Journal ArticleDOI
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
TL;DR: It is shown that STING (stimulator of interferon genes) is critical for the induction of IFN by non-CpG intracellular DNA species produced by various DNA pathogens after infection.
Related Papers (5)
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more