Journal ArticleDOI
Evolutionary Origins of cGAS-STING Signaling
TLDR
The evolutionary origins of the cGAS-STING pathway are discussed, and the possibility that the ancestral functions of STING may have included activation of antibacterial immunity is considered.About:
This article is published in Trends in Immunology.The article was published on 2017-10-01. It has received 187 citations till now. The article focuses on the topics: Sting.read more
Citations
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Journal ArticleDOI
An invertebrate gene encoding a Mab21-containing protein involves in antiviral response through regulating the STING pathway.
TL;DR: In this article, a decapod crustacean Litopenaeus vannamei and designated as LvMab21cp was found to have similar expression profile with other genes in the cGAS-STING pathway, such as LvSTING and LvIRF.
Journal ArticleDOI
Pyrimidines and Cyclic Trinucleotides Join the Second Messenger Symphony.
TL;DR: A family of bacterial nucleotidyltransferases capable of synthesizing pyrimidine containing cyclic din nucleotides and cyclic trinucleotides is defined, suggesting that they play important roles in bacterial physiology and modulation of the metazoan host innate immune system.
Journal ArticleDOI
Protein Phosphatase PP1 Negatively Regulates IRF3 in Response to GCRV Infection in Grass Carp (Ctenopharyngodon idella)
TL;DR: In this paper, the PPP1R3G homolog was identified in the grass carp (Ctenopharyngodon idella) and its role in defence against the GCRV infection was investigated.
Journal ArticleDOI
Interfering with Interferons: A Critical Mechanism for Critical COVID-19 Pneumonia.
TL;DR: This article showed that insufficient type I interferon during the first days of infection as a general mechanism underlying critical COVID-19 pneumonia, with implications for treatment and directions for future research.
Posted ContentDOI
The cyclic dinucleotide 2’3’-cGAMP induces a broad anti-bacterial and anti-viral response in the sea anemone Nematostella vectensis
Shally R. Margolis,Peter A Dietzen,Beth M. Hayes,Stephen C. Wilson,Stephen C. Wilson,Brenna C. Remick,Seemay Chou,Russell E. Vance,Russell E. Vance +8 more
TL;DR: In this paper, the authors used a cyclic dinucleotide (CDN) to activate immune responses in a model cnidarian invertebrate, the starlet sea anemone Nematostella vectensis.
References
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Journal ArticleDOI
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
TL;DR: Results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP, which belongs to the nucleotidyltransferase family.
Journal ArticleDOI
Autophagy in immunity and inflammation
TL;DR: A crucial role is revealed for the autophagy pathway and proteins in immunity and inflammation, and they balance the beneficial and detrimental effects of immunity andinflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.
Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TL;DR: Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
Journal ArticleDOI
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more
TL;DR: The identification of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes is reported, implying a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA.
Journal ArticleDOI
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
TL;DR: It is shown that STING (stimulator of interferon genes) is critical for the induction of IFN by non-CpG intracellular DNA species produced by various DNA pathogens after infection.
Related Papers (5)
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more