Journal ArticleDOI
Evolutionary Origins of cGAS-STING Signaling
TLDR
The evolutionary origins of the cGAS-STING pathway are discussed, and the possibility that the ancestral functions of STING may have included activation of antibacterial immunity is considered.About:
This article is published in Trends in Immunology.The article was published on 2017-10-01. It has received 187 citations till now. The article focuses on the topics: Sting.read more
Citations
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Penaeus monodon Interferon Regulatory Factor (PmIRF) Activates IFNs and Antimicrobial Peptide Expression via a STING-Dependent DNA Sensing Pathway
TL;DR: Results indicate that PmIRF transduces the pathogen signal via the PmDDX41–PmSTING DNA sensing pathway to induce downstream production of interferon-like molecules and antimicrobial peptides.
Journal ArticleDOI
The cyclic guanosine monophosphate synthase-stimulator of interferon genes pathway as a potential target for tumor immunotherapy
TL;DR: In this paper , the authors highlight the latest understanding of the cGAS-STING pathway in tumor development and the advances in combination therapy of STING agonists and immunotherapy.
Journal ArticleDOI
A RAC-alpha serine/threonine-protein kinase (CgAKT1) involved in the synthesis of CgIFNLP in oyster Crassostrea gigas.
Lilin Hou,Xue Qiao,Youjing Li,Yuhao Jin,Ranyang Liu,Sicong Wang,Kai Zhi Zhou,Lingling Wang,Linsheng Song +8 more
TL;DR: In this paper , a novel RAC-alpha serine/threonine-protein kinase (AKT) homologue named CgAKT1 was identified from the Pacific oyster Crassostrea gigas.
Journal ArticleDOI
HSV Replication: Triggering and Repressing STING Functionality
TL;DR: In this paper , the authors highlight recent progress involving HSV interactions with the STING pathway, with a focus on how STING influences HSV replication and pathogenesis, and highlight how the pathway influences the pathogenesis of HSV.
Journal ArticleDOI
Expanding evolutionary theories of ageing to better account for symbioses and interactions throughout the Web of Life
Eric Bapteste,Philippe Huneman,Laurent Keller,Jérôme Teulière,Philippe Lopez,Emma C. Teeling,Ariel B. Lindner,Annette Baudisch,William B. Ludington,Claudio Franceschi +9 more
TL;DR: In this paper , the effects of organismal interactions on ageing across different levels of biological organisation, and consider the impact of surrounding and nested systems on organismal ageing, are examined.
References
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Journal ArticleDOI
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
TL;DR: Results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP, which belongs to the nucleotidyltransferase family.
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Autophagy in immunity and inflammation
TL;DR: A crucial role is revealed for the autophagy pathway and proteins in immunity and inflammation, and they balance the beneficial and detrimental effects of immunity andinflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.
Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TL;DR: Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
Journal ArticleDOI
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more
TL;DR: The identification of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes is reported, implying a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA.
Journal ArticleDOI
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
TL;DR: It is shown that STING (stimulator of interferon genes) is critical for the induction of IFN by non-CpG intracellular DNA species produced by various DNA pathogens after infection.
Related Papers (5)
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more