Journal ArticleDOI
Evolutionary Origins of cGAS-STING Signaling
TLDR
The evolutionary origins of the cGAS-STING pathway are discussed, and the possibility that the ancestral functions of STING may have included activation of antibacterial immunity is considered.About:
This article is published in Trends in Immunology.The article was published on 2017-10-01. It has received 187 citations till now. The article focuses on the topics: Sting.read more
Citations
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Journal ArticleDOI
cGAS in action: Expanding roles in immunity and inflammation
Andrea Ablasser,Zhijian J. Chen +1 more
TL;DR: The latest advances uncovering how cGAS and STING control inflammatory responses and are themselves regulated are reviewed, suggesting a major clinical impact in areas of cancer immunotherapy and vaccine development.
Journal ArticleDOI
The cGAS-STING pathway as a therapeutic target in inflammatory diseases.
TL;DR: The cGAS-STING pathway has emerged as a key mediator of inflammation in the settings of infection, cellular stress and tissue damage as discussed by the authors, which has enabled the development of selective small-molecule inhibitors with the potential to target the CGS-STing axis in a number of inflammatory diseases.
Journal ArticleDOI
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3
Moritz M. Gaidt,Thomas S. Ebert,Dhruv Chauhan,Katharina Ramshorn,Francesca Pinci,Sarah Zuber,Fionan O’Duill,Jonathan L. Schmid-Burgk,Florian Hoss,Raymund Buhmann,Georg Wittmann,Eicke Latz,Eicke Latz,Marion Subklewe,Veit Hornung +14 more
TL;DR: It is shown that AIM2 is dispensable for DNA-mediated inflammasome activation in human myeloid cells, and targeting the cGAS-STING-LCD-NLRP3 pathway will ameliorate pathology in inflammatory conditions that are associated with cytosolic DNA sensing.
Journal ArticleDOI
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Haipeng Liu,Haiping Zhang,Xiangyang Wu,Dapeng Ma,Juehui Wu,Lin Wang,Yan Jiang,Yiyan Fei,Chenggang Zhu,Rong Tan,Peter R. Jungblut,Gang Pei,Anca Dorhoi,Anca Dorhoi,Qiaoling Yan,Fan Zhang,Ruijuan Zheng,Siyu Liu,Haijiao Liang,Zhonghua Liu,Hua Yang,Jianxia Chen,Peng Wang,Tianqi Tang,Wenxia Peng,Zhangsen Hu,Zhu Xu,Xiaochen Huang,Jie Wang,Haohao Li,Yilong Zhou,Feng Liu,Dapeng Yan,Stefan H. E. Kaufmann,Chang Chen,Zhiyong Mao,Baoxue Ge +36 more
TL;DR: It is concluded that nuclear cGAS suppresses homologous-recombination-mediated repair and promotes tumour growth, and that cGas therefore represents a potential target for cancer prevention and therapy.
Journal ArticleDOI
Cyclic GMP-AMP signalling protects bacteria against viral infection.
Daniel Cohen,Sarah Melamed,Adi Millman,Gabriela Shulman,Yaara Oppenheimer-Shaanan,Assaf Kacen,Shany Doron,Gil Amitai,Rotem Sorek +8 more
TL;DR: cGAMP signalling in bacteria mediates anti-phage defence, as part of a genetic system suggested to be the ancient ancestor of the animal cGAS–STING innate immune pathway.
References
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Journal ArticleDOI
The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy
Robert O. Watson,Samantha L. Bell,Donna A. MacDuff,Jacqueline M. Kimmey,Elie J. Diner,Joanna Olivas,Russell E. Vance,Christina L. Stallings,Herbert W. Virgin,Jeffery S. Cox +9 more
TL;DR: It is reported that the cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is required for activating IFN production via the STING/TBK1/IRF3 pathway during M. tuberculosis and L. pneumophila infection of macrophages, whereas L. monocytogenes short-circuits this pathway by producing the STing agonist, c-di-AMP.
Journal ArticleDOI
Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF-κB Activation through TBK1
Takayuki Abe,Glen N. Barber +1 more
TL;DR: STING has been identified as a critical signaling molecule required for the detection of cytosolic dsDNAs derived from pathogens and viruses and TBK1 is established as a downstream kinase controlling dsDNA-mediated IRF3 and NF-κB signaling dependent on STING.
Journal ArticleDOI
Innate immune recognition of the microbiota promotes host-microbial symbiosis
Hiutung Chu,Sarkis K. Mazmanian +1 more
TL;DR: Evidence from both invertebrate and vertebrate models reveals that innate immune receptors are required to promote long-term colonization by the microbiota and suggests that PRRs may have evolved, in part, to mediate the bidirectional cross-talk between microbial symbionts and their hosts.
Journal ArticleDOI
Mice Lacking the Type I Interferon Receptor Are Resistant to Listeria monocytogenes
Victoria Auerbuch,Dirk G. Brockstedt,Nicole Meyer-Morse,Mary X. D. O'Riordan,Daniel A. Portnoy +4 more
TL;DR: In this article, the role of type I IFNs in immunity to bacterial pathogens was examined by examining the infection of Listeria monocytogenes in BALB/c mice lacking the type I interferon (IFN)-β.
Journal ArticleDOI
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
Elena A. Levashina,Emma Langley,Clare Green,David Gubb,Michael Ashburner,Jules A. Hoffmann,Jean-Marc Reichhart +6 more
TL;DR: A loss-of-function mutation in the gene encoding a blood serine protease inhibitor, Spn43Ac, was shown to lead to constitutive expression of the antifungal peptide drosomycin, and this effect was mediated by the spaetzle and Toll gene products.
Related Papers (5)
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more