Journal ArticleDOI
Evolutionary Origins of cGAS-STING Signaling
TLDR
The evolutionary origins of the cGAS-STING pathway are discussed, and the possibility that the ancestral functions of STING may have included activation of antibacterial immunity is considered.About:
This article is published in Trends in Immunology.The article was published on 2017-10-01. It has received 187 citations till now. The article focuses on the topics: Sting.read more
Citations
More filters
Journal ArticleDOI
cGAS in action: Expanding roles in immunity and inflammation
Andrea Ablasser,Zhijian J. Chen +1 more
TL;DR: The latest advances uncovering how cGAS and STING control inflammatory responses and are themselves regulated are reviewed, suggesting a major clinical impact in areas of cancer immunotherapy and vaccine development.
Journal ArticleDOI
The cGAS-STING pathway as a therapeutic target in inflammatory diseases.
TL;DR: The cGAS-STING pathway has emerged as a key mediator of inflammation in the settings of infection, cellular stress and tissue damage as discussed by the authors, which has enabled the development of selective small-molecule inhibitors with the potential to target the CGS-STing axis in a number of inflammatory diseases.
Journal ArticleDOI
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3
Moritz M. Gaidt,Thomas S. Ebert,Dhruv Chauhan,Katharina Ramshorn,Francesca Pinci,Sarah Zuber,Fionan O’Duill,Jonathan L. Schmid-Burgk,Florian Hoss,Raymund Buhmann,Georg Wittmann,Eicke Latz,Eicke Latz,Marion Subklewe,Veit Hornung +14 more
TL;DR: It is shown that AIM2 is dispensable for DNA-mediated inflammasome activation in human myeloid cells, and targeting the cGAS-STING-LCD-NLRP3 pathway will ameliorate pathology in inflammatory conditions that are associated with cytosolic DNA sensing.
Journal ArticleDOI
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Haipeng Liu,Haiping Zhang,Xiangyang Wu,Dapeng Ma,Juehui Wu,Lin Wang,Yan Jiang,Yiyan Fei,Chenggang Zhu,Rong Tan,Peter R. Jungblut,Gang Pei,Anca Dorhoi,Anca Dorhoi,Qiaoling Yan,Fan Zhang,Ruijuan Zheng,Siyu Liu,Haijiao Liang,Zhonghua Liu,Hua Yang,Jianxia Chen,Peng Wang,Tianqi Tang,Wenxia Peng,Zhangsen Hu,Zhu Xu,Xiaochen Huang,Jie Wang,Haohao Li,Yilong Zhou,Feng Liu,Dapeng Yan,Stefan H. E. Kaufmann,Chang Chen,Zhiyong Mao,Baoxue Ge +36 more
TL;DR: It is concluded that nuclear cGAS suppresses homologous-recombination-mediated repair and promotes tumour growth, and that cGas therefore represents a potential target for cancer prevention and therapy.
Journal ArticleDOI
Cyclic GMP-AMP signalling protects bacteria against viral infection.
Daniel Cohen,Sarah Melamed,Adi Millman,Gabriela Shulman,Yaara Oppenheimer-Shaanan,Assaf Kacen,Shany Doron,Gil Amitai,Rotem Sorek +8 more
TL;DR: cGAMP signalling in bacteria mediates anti-phage defence, as part of a genetic system suggested to be the ancient ancestor of the animal cGAS–STING innate immune pathway.
References
More filters
Journal ArticleDOI
Cytosolic Sensing of Viruses
TL;DR: Recent advances in the molecular understanding of cytosolic nucleic acid detection and its evasion by viruses are detailed.
Journal ArticleDOI
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
Tatsuya Saitoh,Naonobu Fujita,Takuya Hayashi,Keigo Takahara,Takashi Satoh,Hanna Lee,Hanna Lee,Kohichi Matsunaga,Shun Kageyama,Hiroko Omori,Takeshi Noda,Naoki Yamamoto,Taro Kawai,Ken Ishii,Osamu Takeuchi,Tamotsu Yoshimori,Shizuo Akira +16 more
TL;DR: It is demonstrated that dynamic membrane traffic mediates the sequential translocation and assembly of STING, both of which are essential processes required for maximal activation of the innate immune response triggered by dsDNA.
Journal ArticleDOI
Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway
TL;DR: It is shown that phagosomal permeabilization mediated by the bacterial ESX-1 secretion system allows cytosolic components of the ubiquitin-mediated autophagy pathway access to Phagosomal M. tuberculosis infection and indicates a major role for this autophagic pathway in resistance to M.culosis.
Journal ArticleDOI
Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product.
TL;DR: Experiments suggest that the activity of the Toll product is normally regulated by other dorsal-group genes and that the function of the toll product is to provide the source for a morphogen gradient in the dorsal-ventral axis of the wild-type embryo.
Journal ArticleDOI
The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING
Elie J. Diner,Dara Burdette,Stephen C. Wilson,Kathryn M. Monroe,Colleen A. Kellenberger,Mamoru Hyodo,Yoshihiro Hayakawa,Ming C. Hammond,Russell E. Vance +8 more
TL;DR: Natural variants of human STING (hSTING) are identified that are poorly responsive to cGAMP yet, unexpectedly, are normally responsive to DNA and cGAS signaling, which indicates that hSTING variants have evolved to distinguish conventional (3'-5') cyclic dinucleotides from the noncanonical cyclic Dinucleotide produced by mammalian cGAS.
Related Papers (5)
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more