Journal ArticleDOI
Evolutionary Origins of cGAS-STING Signaling
TLDR
The evolutionary origins of the cGAS-STING pathway are discussed, and the possibility that the ancestral functions of STING may have included activation of antibacterial immunity is considered.About:
This article is published in Trends in Immunology.The article was published on 2017-10-01. It has received 187 citations till now. The article focuses on the topics: Sting.read more
Citations
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Journal ArticleDOI
cGAS in action: Expanding roles in immunity and inflammation
Andrea Ablasser,Zhijian J. Chen +1 more
TL;DR: The latest advances uncovering how cGAS and STING control inflammatory responses and are themselves regulated are reviewed, suggesting a major clinical impact in areas of cancer immunotherapy and vaccine development.
Journal ArticleDOI
The cGAS-STING pathway as a therapeutic target in inflammatory diseases.
TL;DR: The cGAS-STING pathway has emerged as a key mediator of inflammation in the settings of infection, cellular stress and tissue damage as discussed by the authors, which has enabled the development of selective small-molecule inhibitors with the potential to target the CGS-STing axis in a number of inflammatory diseases.
Journal ArticleDOI
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3
Moritz M. Gaidt,Thomas S. Ebert,Dhruv Chauhan,Katharina Ramshorn,Francesca Pinci,Sarah Zuber,Fionan O’Duill,Jonathan L. Schmid-Burgk,Florian Hoss,Raymund Buhmann,Georg Wittmann,Eicke Latz,Eicke Latz,Marion Subklewe,Veit Hornung +14 more
TL;DR: It is shown that AIM2 is dispensable for DNA-mediated inflammasome activation in human myeloid cells, and targeting the cGAS-STING-LCD-NLRP3 pathway will ameliorate pathology in inflammatory conditions that are associated with cytosolic DNA sensing.
Journal ArticleDOI
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Haipeng Liu,Haiping Zhang,Xiangyang Wu,Dapeng Ma,Juehui Wu,Lin Wang,Yan Jiang,Yiyan Fei,Chenggang Zhu,Rong Tan,Peter R. Jungblut,Gang Pei,Anca Dorhoi,Anca Dorhoi,Qiaoling Yan,Fan Zhang,Ruijuan Zheng,Siyu Liu,Haijiao Liang,Zhonghua Liu,Hua Yang,Jianxia Chen,Peng Wang,Tianqi Tang,Wenxia Peng,Zhangsen Hu,Zhu Xu,Xiaochen Huang,Jie Wang,Haohao Li,Yilong Zhou,Feng Liu,Dapeng Yan,Stefan H. E. Kaufmann,Chang Chen,Zhiyong Mao,Baoxue Ge +36 more
TL;DR: It is concluded that nuclear cGAS suppresses homologous-recombination-mediated repair and promotes tumour growth, and that cGas therefore represents a potential target for cancer prevention and therapy.
Journal ArticleDOI
Cyclic GMP-AMP signalling protects bacteria against viral infection.
Daniel Cohen,Sarah Melamed,Adi Millman,Gabriela Shulman,Yaara Oppenheimer-Shaanan,Assaf Kacen,Shany Doron,Gil Amitai,Rotem Sorek +8 more
TL;DR: cGAMP signalling in bacteria mediates anti-phage defence, as part of a genetic system suggested to be the ancient ancestor of the animal cGAS–STING innate immune pathway.
References
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Journal ArticleDOI
Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses.
Qiming Liang,Gil Ju Seo,Youn Jung Choi,Mi Jeong Kwak,Jianning Ge,Mary A. Rodgers,Mude Shi,Benjamin J. Leslie,Karl-Peter Hopfner,Taekjip Ha,Taekjip Ha,Byung-Ha Oh,Jae U. Jung +12 more
TL;DR: The cGAS-Beclin-1 interaction shapes innate immune responses by regulating both cGAMP production and autophagy, resulting in well-balanced antimicrobial immune responses.
Journal ArticleDOI
Identification of a second group of type I IFNs in fish sheds light on IFN evolution in vertebrates.
TL;DR: The data overall support the concept that different vertebrate groups have independently expanded their IFN types, with deletion of different pairs of cysteines apparent in fish group I IFN and IFN-βε of mammals.
Journal ArticleDOI
Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection
Jacqueline M. Kimmey,Jeremy P. Huynh,Leslie A. Weiss,Sunmin Park,Amal Kambal,Jayanta Debnath,Herbert W. Virgin,Christina L. Stallings +7 more
TL;DR: It is shown that, contrary to expectation, autophagic capacity does not correlate with the outcome of M. tuberculosis infection in vivo, and ATG5 plays a unique role in protection against M.culosis by preventing PMN-mediated immunopathology.
Journal ArticleDOI
MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP
Lei Jin,Krista K. Hill,Holly C. Filak,Jennifer Mogan,Heather Knowles,Bicheng Zhang,Anne-Laure Perraud,John C. Cambier,Laurel L. Lenz +8 more
TL;DR: It is shown that bifurcating MPYS-dependent and -independent pathways mediate sensing of cytosolic bacterial infections, and that type I IFN production by cultured macrophages infected with the intracellular pathogens Listeria monocytogenes and Francisella tularensis is required.
Journal ArticleDOI
Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system.
TL;DR: STING (stimulator of interferon genes) is an innate immune sensor of cyclic dinucleotides that regulates the induction of type I interferons.
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