Journal ArticleDOI
Evolutionary Origins of cGAS-STING Signaling
TLDR
The evolutionary origins of the cGAS-STING pathway are discussed, and the possibility that the ancestral functions of STING may have included activation of antibacterial immunity is considered.About:
This article is published in Trends in Immunology.The article was published on 2017-10-01. It has received 187 citations till now. The article focuses on the topics: Sting.read more
Citations
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Journal ArticleDOI
The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans
TL;DR: The arms race that exists between viruses and their animal hosts is illustrated by the dynamic evolution and diversification of innate immune pathways, not only important to understand virus-host interactions in general but may also be relevant for the development of novel curative approaches against human disease.
Journal ArticleDOI
Characterization of cGAS homologs in innate and adaptive mucosal immunities in zebrafish gives evolutionary insights into cGAS-STING pathway.
Zhi-fei Liu,Jian-fei Ji,Xiao-feng Jiang,Tong Shao,Dong-Dong Fan,Xin-Hang Jiang,Aifu Lin,Li-Xin Xiang,Jian-Zhong Shao +8 more
TL;DR: Experimental evidence is provided that a modern cGAS‐STING pathway that mainly participates in IFN‐mediated immunity originated from teleost fish based on the functional constraint of cGas and STING proteins during vertebrate evolution.
Journal ArticleDOI
Sensing and signalling viral infection in drosophila
TL;DR: Recent developments in the field begin to shed light on the mechanisms involved in sensing of viral infections and in signalling leading to production of antiviral effectors in drosophila.
Journal ArticleDOI
PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection.
Zhenyu Wang,Jing Chen,Xingchen Wu,Dan Ma,Xiaohua Zhang,Ruizhen Li,Cong Han,Haixin Liu,Xiangrui Yin,Qian Du,Dewen Tong,Yong Huang +11 more
TL;DR: Zhang et al. as mentioned in this paper found that PCV2 Cap and its binding protein gC1qR act as predominant regulators to promote porcine cGAS phosphorylation and HDAC6 activation through mediating PI3K/AKT signaling and PKCδ signaling activation.
Journal ArticleDOI
Bacteriophages inhibit and evade cGAS-like immune function in bacteria
Erin D Huiting,Xueli Cao,Jie Ren,Januka S Athukoralage,Z Luo,Sukrit Silas,Na An,Heloise Carion,Yu Zhou,James S. Fraser,Yue Feng,Joseph Bondy-Denomy +11 more
TL;DR: In this article , an endogenous cGAS-like enzyme was identified in Pseudomonas aeruginosa that generates 3',3'-cGAMP during phage infection, signals to a phospholipase effector, and limits phage replication.
References
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Journal ArticleDOI
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
TL;DR: Results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP, which belongs to the nucleotidyltransferase family.
Journal ArticleDOI
Autophagy in immunity and inflammation
TL;DR: A crucial role is revealed for the autophagy pathway and proteins in immunity and inflammation, and they balance the beneficial and detrimental effects of immunity andinflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.
Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TL;DR: Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
Journal ArticleDOI
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more
TL;DR: The identification of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes is reported, implying a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA.
Journal ArticleDOI
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
TL;DR: It is shown that STING (stimulator of interferon genes) is critical for the induction of IFN by non-CpG intracellular DNA species produced by various DNA pathogens after infection.
Related Papers (5)
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more