Exposure to diagnostic radiation and risk of breast cancer among carriers of BRCA1/2 mutations: retrospective cohort study (GENE-RAD-RISK)
Anouk Pijpe,Nadine Andrieu,Nadine Andrieu,Nadine Andrieu,Douglas F. Easton,Ausrele Kesminiene,Elisabeth Cardis,Catherine Noguès,Marion Gauthier-Villars,Christine Lasset,Jean-Pierre Fricker,Susan Peock,Debra Frost,D. Gareth Evans,Rosalind A. Eeles,Joan Paterson,Peggy Manders,Peggy Manders,Christi J. van Asperen,Margreet G. E. M. Ausems,Hanne Meijers-Heijboer,Isabelle Thierry-Chef,Michael Hauptmann,David E. Goldgar,Matti A. Rookus,Flora E. van Leeuwen +25 more
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The use of non-ionising radiation imaging techniques (such as magnetic resonance imaging) as the main tool for surveillance in young women with BRCA1/2 mutations is supported, at dose levels considerably lower than those at which increases have been found in other cohorts exposed to radiation.Abstract:
Objective To estimate the risk of breast cancer associated with diagnostic radiation in carriers of BRCA1/2 mutations. Design Retrospective cohort study (GENE-RAD-RISK). Setting Three nationwide studies (GENEPSO, EMBRACE, HEBON) in France, United Kingdom, and the Netherlands, Participants 1993 female carriers of BRCA1/2 mutations recruited in 2006-09. Main outcome measure Risk of breast cancer estimated with a weighted Cox proportional hazards model with a time dependent individually estimated cumulative breast dose, based on nominal estimates of organ dose and frequency of self reported diagnostic procedures. To correct for potential survival bias, the analysis excluded carriers who were diagnosed more than five years before completion of the study questionnaire. Results In carriers of BRCA1/2 mutations any exposure to diagnostic radiation before the age of 30 was associated with an increased risk of breast cancer (hazard ratio 1.90, 95% confidence interval 1.20 to 3.00), with a dose-response pattern. The risks by quarter of estimated cumulative dose Conclusion In this large European study among carriers of BRCA1/2 mutations, exposure to diagnostic radiation before age 30 was associated with an increased risk of breast cancer at dose levels considerably lower than those at which increases have been found in other cohorts exposed to radiation. The results of this study support the use of non-ionising radiation imaging techniques (such as magnetic resonance imaging) as the main tool for surveillance in young women with BRCA1/2 mutations.read more
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References
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Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies
Antonis C. Antoniou,Paul D.P. Pharoah,Steven A. Narod,Harvey A. Risch,Jorunn E. Eyfjord,John L. Hopper,Niklas Loman,Håkan Olsson,Oskar T. Johannsson,Åke Borg,Barbara Pasini,Paolo Radice,Siranoush Manoukian,Diana Eccles,Nelson L.S. Tang,E. Olah,Hoda Anton-Culver,Ellen Warner,Jan Lubinski,Jacek Gronwald,Bohdan Górski,Hrafn Tulinius,Steinunn Thorlacius,Hannaleena Eerola,Heli Nevanlinna,Kirsi Syrjäkoski,Olli Kallioniemi,Deborah J. Thompson,Christopher H. Evans,Julian Peto,Julian Peto,Fiona Lalloo,D G R Evans,Douglas F. Easton +33 more
TL;DR: Risks in carriers were higher when based on index breast cancer cases diagnosed at <35 years of age and for variation in risk by mutation position for both genes, and some evidence for a reduction in risk in women from earlier birth cohorts is found.
Book
Health Risks from Exposure to Low Levels of Ionizing Radiation:: BEIR VII Phase 2
TL;DR: Health risks from exposure to low levels of ionizing radiation : BEIR VII Phase 2 , Health risks from Exposure to low Levels of Ionizing radiation: BEIR VIII Phase 2, شاپور اهواز.
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Cancer Susceptibility and the Functions of BRCA1 and BRCA2
TL;DR: What is known about the biological functions of the BRCA proteins is examined and how their disruption can induce susceptibility to specific types of cancer is asked.
Journal ArticleDOI
Meta-analysis of BRCA1 and BRCA2 penetrance
Sining Chen,Giovanni Parmigiani +1 more
TL;DR: A set of risk estimates for BRCa1 and BRCA2 mutation carriers that can be used by counselors and clinicians who are interested in advising patients based on a comprehensive set of studies rather than one specific study are provided.
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Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage
Kiyotsugu Yoshida,Yoshio Miki +1 more
TL;DR: Elucidation of the precise molecular functions of BRCAs is expected to improve the understanding of hereditary as well as sporadic mammary carcinogenesis and protect the genome from damage.
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