Flavivirus-induced antibody cross-reactivity
Karen L. Mansfield,Karen L. Mansfield,Daniel L. Horton,Daniel L. Horton,Nicholas Johnson,Li Li,Alan D.T. Barrett,Derek J. Smith,Sareen E. Galbraith,Tom Solomon,Anthony R. Fooks,Anthony R. Fooks +11 more
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TLDR
It is evident from these data that notable differences exist between amino acid sequence identity and mapped antigenic relationships within the family Flaviviridae.Abstract:
Dengue viruses (DENV) cause countless human deaths each year, whilst West Nile virus (WNV) has re-emerged as an important human pathogen. There are currently no WNV or DENV vaccines licensed for human use, yet vaccines exist against other flaviviruses. To investigate flavivirus cross-reactivity, sera from a human cohort with a history of vaccination against tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV) and yellow fever virus (YFV) were tested for antibodies by plaque reduction neutralization test. Neutralization of louping ill virus (LIV) occurred, but no significant neutralization of Murray Valley encephalitis virus was observed. Sera from some individuals vaccinated against TBEV and JEV neutralized WNV, which was enhanced by YFV vaccination in some recipients. Similarly, some individuals neutralized DENV-2, but this was not significantly influenced by YFV vaccination. Antigenic cartography techniques were used to generate a geometric illustration of the neutralization titres of selected sera against WNV, TBEV, JEV, LIV, YFV and DENV-2. This demonstrated the individual variation in antibody responses. Most sera had detectable titres against LIV and some had titres against WNV and DENV-2. Generally, LIV titres were similar to titres against TBEV, confirming the close antigenic relationship between TBEV and LIV. JEV was also antigenically closer to TBEV than WNV, using these sera. The use of sera from individuals vaccinated against multiple pathogens is unique relative to previous applications of antigenic cartography techniques. It is evident from these data that notable differences exist between amino acid sequence identity and mapped antigenic relationships within the family Flaviviridae.read more
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Journal ArticleDOI
Dengue viruses cluster antigenically but not as discrete serotypes
Leah C. Katzelnick,Judith M. Fonville,Judith M. Fonville,Judith M. Fonville,Gregory D. Gromowski,Jose Bustos Arriaga,Angela M. Green,Sarah James,Sarah James,Louis Lau,Magelda Montoya,Chunling Wang,Laura A. VanBlargan,Colin A. Russell,Hlaing Myat Thu,Theodore C. Pierson,Philippe Buchy,John Aaskov,Jorge L. Muñoz-Jordán,Nikos Vasilakis,Robert V. Gibbons,Robert B. Tesh,Albert D. M. E. Osterhaus,Ron A. M. Fouchier,Anna P. Durbin,Cameron P. Simmons,Cameron P. Simmons,Edward C. Holmes,Eva Harris,Stephen S. Whitehead,Derek J. Smith,Derek J. Smith,Derek J. Smith +32 more
TL;DR: Dengue viruses show as much divergence within a type as between types, which helps explain why immune responses to dengue are highly variable, and it has complex implications for epidemiology, disease, and vaccine deployment.
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Deciphering serology to understand the ecology of infectious diseases in wildlife.
Amy T. Gilbert,Anthony R. Fooks,Anthony R. Fooks,David T. S. Hayman,Daniel L. Horton,Thomas Müller,Raina K. Plowright,Alison J. Peel,Alison J. Peel,Richard A. Bowen,James L. N. Wood,James N. Mills,Andrew A. Cunningham,Charles E. Rupprecht,Charles E. Rupprecht +14 more
TL;DR: Greater consideration of population age structure and cohort representation, serological test suitability and standardized sample collection protocols can ensure that reliable data are obtained for downstream modeling applications to characterize, and evaluate interventions for, wildlife disease systems.
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Neurologic Complications Associated With the Zika Virus in Brazilian Adults.
Ivan Rocha Ferreira da Silva,Jennifer A. Frontera,Ana Maria Bispo de Filippis,Osvaldo J. M. Nascimento +3 more
TL;DR: ZIKV infection was associated with an increase in the incidence of a diverse spectrum of serious neurologic syndromes and the data suggest that serologic and molecular testing using blood and cerebrospinal fluid samples can serve as a less expensive, alternative diagnostic strategy in developing countries, where plaque reduction neutralization testing is impractical.
Journal ArticleDOI
Flaviviruses in Europe: complex circulation patterns and their consequences for the diagnosis and control of West Nile disease.
Cécile Beck,Miguel Ángel Jiménez-Clavero,Agnès Leblond,Benoit Durand,Norbert Nowotny,Isabelle Leparc-Goffart,Stéphan Zientara,Elsa Jourdain,Sylvie Lecollinet +8 more
TL;DR: The challenges involved in interpreting flavivirus serological tests and setting up appropriate surveillance programs are presented and the consequences of flaviv virus circulation and vaccination for host immunity are addressed.
Journal ArticleDOI
Fever versus Fever: the role of host and vector susceptibility and interspecific competition in shaping the current and future distributions of the sylvatic cycles of dengue virus and yellow fever virus
Kathryn A. Hanley,Thomas P. Monath,Scott C. Weaver,Shannan L. Rossi,Rebecca Richman,Nikos Vasilakis +5 more
TL;DR: This review summarizes current understanding of sylvatic transmission cycles of YFV and DENV, considers possible explanations for their disjunct distributions, and speculates on the potential consequences of future establishment of a sylvatics cycle of DENV in the Americas.
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Journal ArticleDOI
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Charles H. Calisher,Nick Karabatsos,Joel M. Dalrymple,Robert E. Shope,James S. Porterfield,Edwin G. Westaway,Walter E. Brandt +6 more
TL;DR: The recently established virus family Flaviviridae contains at least 68 recognized members; sixty-six of these viruses were tested by cross-neutralization in cell cultures and 17 other viruses were not sufficiently related to warrant inclusion in any of these complexes.
Journal ArticleDOI
The Global Circulation of Seasonal Influenza A (H3N2) Viruses
Colin A. Russell,Terry Jones,Terry Jones,Terry Jones,Ian G. Barr,Nancy J. Cox,Rebecca Garten,V. Gregory,Ian D. Gust,Alan W. Hampson,Alan J. Hay,Aeron C. Hurt,Jan C. de Jong,Anne Kelso,Alexander Klimov,Tsutomu Kageyama,Naomi Komadina,Alan Lapedes,Yi P. Lin,Ana Mosterin,Ana Mosterin,Masatsugu Obuchi,Takato Odagiri,Albert D. M. E. Osterhaus,Guus F. Rimmelzwaan,Michael W. Shaw,Eugene Skepner,Klaus Stöhr,Masato Tashiro,Ron A. M. Fouchier,Derek J. Smith,Derek J. Smith +31 more
TL;DR: There was continuous circulation in east and Southeast Asia via a region-wide network of temporally overlapping epidemics and that epidemics in the temperate regions were seeded from this network each year, suggesting that once A (H3N2) viruses leave E-SE Asia, they are unlikely to contribute to long-term viral evolution.
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