Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
Wei Gao,Wei Gao,Sam Emaminejad,Sam Emaminejad,Sam Emaminejad,Hnin Yin Yin Nyein,Hnin Yin Yin Nyein,Samyuktha Challa,Kevin Chen,Kevin Chen,Austin J Peck,Hossain M. Fahad,Hossain M. Fahad,Hiroki Ota,Hiroki Ota,Hiroshi Shiraki,Hiroshi Shiraki,Daisuke Kiriya,Daisuke Kiriya,Der Hsien Lien,George A. Brooks,Ronald W. Davis,Ali Javey,Ali Javey +23 more
TLDR
This work bridges the technological gap between signal transduction, conditioning, processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.Abstract:
Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.read more
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Monitoring body movement or condition according to motion regimen with conformal electronics
Eleanor V. Goodall,Roderick A. Hyde,Jordin T. Kare,Eric C. Leuthardt,Mark A. Malamud,Gary L. McKnight,Tony S. Pan,Katherine E. Sharadin,Elizabeth A. Sweeney,Clarence T. Tegreene,Charles Whitmer,Lowell L. Wood +11 more
TL;DR: In this paper, the authors describe a system for monitoring an individual subject and facilitating a motion regimen of the individual subject, which includes a deformable substrate, a sensor assembly configured to generate one or more sense signals based on detection of at least one of a movement of the body portion or one physiological parameter of the human body portion, and an effector operably coupled to the processor.
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Bioinspired, Superhydrophobic, and Paper-Based Strain Sensors for Wearable and Underwater Applications
Liu Linpeng,Jiao Zhibin,Junqiu Zhang,Yuchen Wang,Zhang Changchao,Meng Xiancun,Xiaohu Jiang,Shichao Niu,Shichao Niu,Zhiwu Han,Luquan Ren +10 more
TL;DR: In this article, a paper-based strain sensor with high sensitivity and water repellency is successfully fabricated, which exhibits a gauge factor of 263.34, a high strain resolution (0.098%), a fast response time (78 ms), excellent stability over 12,000 cycles, and a water contact angle of 164°.
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Wireless Monitoring of Small Strains in Intelligent Robots via a Joule Heating Effect in Stretchable Graphene–Polymer Nanocomposites
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Multiscale Soft-Hard Interface Design for Flexible Hybrid Electronics.
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Journal ArticleDOI
Lactate Biosensing for Reliable On-Body Sweat Analysis
TL;DR: In this paper, an outer plasticized polymeric layer containing the quaternary salt tetradodecylammonium tetrakis(4-chlorophenyl) borate (traditionally known as ETH500) is used to prevent the enzyme from being in direct contact with the sample, and hence, any influence with pH and temperature is dramatically reduced.
References
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