Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
Wei Gao,Wei Gao,Sam Emaminejad,Sam Emaminejad,Sam Emaminejad,Hnin Yin Yin Nyein,Hnin Yin Yin Nyein,Samyuktha Challa,Kevin Chen,Kevin Chen,Austin J Peck,Hossain M. Fahad,Hossain M. Fahad,Hiroki Ota,Hiroki Ota,Hiroshi Shiraki,Hiroshi Shiraki,Daisuke Kiriya,Daisuke Kiriya,Der Hsien Lien,George A. Brooks,Ronald W. Davis,Ali Javey,Ali Javey +23 more
TLDR
This work bridges the technological gap between signal transduction, conditioning, processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.Abstract:
Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.read more
Citations
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Resettable skin interfaced microfluidic sweat collection devices with chemesthetic hydration feedback.
Jonathan T. Reeder,Yeguang Xue,Daniel Franklin,Yujun Deng,Yujun Deng,Jungil Choi,Jungil Choi,Olivia Prado,Robin J. Kim,Claire Liu,Justin Hanson,John Ciraldo,Amay J. Bandodkar,Siddharth Krishnan,Alexandra Johnson,Emily Patnaude,Raudel Avila,Yonggang Huang,John A. Rogers +18 more
TL;DR: A resettable microfluidic platform comprising soft pumps and valves that provides triggered release of chemesthetic agents to alert the user of excessive sweat loss is reported.
Journal ArticleDOI
Flexible electrochemical biosensors for health monitoring
Anneng Yang,Feng Yan +1 more
TL;DR: In this article, flexible electrochemical biosensors play an important role in disease diagnosis and healthcare management, and they are mainly used for the diagnosis and management of chronic diseases, such as cancer.
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Efficient Delivery of Power Generated by a Rotating Triboelectric Nanogenerator by Conjunction of Wired and Wireless Transmissions Using Maxwell's Displacement Currents
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Solid-Contact Ion-Selective Electrodes: Response Mechanisms, Transducer Materials and Wearable Sensors
Yan Lyu,Shiyu Gan,Yu Bao,Lijie Zhong,Jianan Xu,Wei Wang,Zhenbang Liu,Ma Yingming,Guifu Yang,Li Niu +9 more
TL;DR: This review reviews recent advances in SC-ISEs including the response mechanism (redox capacitance and electric-double-layer capacitance mechanisms) and crucial solid transducer materials (conducting polymers, carbon and other nanomaterials) and applications in wearable sensors.
Journal ArticleDOI
Microbial nanocellulose adherent to human skin used in electrochemical sensors to detect metal ions and biomarkers in sweat
Robson Rosa da Silva,Paulo A. Raymundo-Pereira,Anderson M. Campos,Deivy Wilson,Caio G. Otoni,Hernane da Silva Barud,C.A.R. Costa,Rafael R. Domeneguetti,Débora Terezia Balogh,Sidney José Lima Ribeiro,Osvaldo N. Oliveira +10 more
TL;DR: MNC was exploited as an adhesive-free, yet highly skin-adherent platform for wearable sensing devices that also benefit from the semi-permeable, non-allergenic, and renewable features that make MNC unique within the pool of materials that have been used for such a purpose.
References
More filters
Journal ArticleDOI
Skin-like pressure and strain sensors based on transparent elastic films of carbon nanotubes
Darren J. Lipomi,Michael Vosgueritchian,Benjamin C. K. Tee,Sondra L. Hellstrom,Jennifer A. Lee,Courtney H. Fox,Zhenan Bao +6 more
TL;DR: Transparent, conducting spray-deposited films of single-walled carbon nanotubes are reported that can be rendered stretchable by applying strain along each axis, and then releasing this strain.
Journal ArticleDOI
An ultra-lightweight design for imperceptible plastic electronics
Martin Kaltenbrunner,Tsuyoshi Sekitani,Tsuyoshi Sekitani,Jonathan T. Reeder,Jonathan T. Reeder,Tomoyuki Yokota,Kazunori Kuribara,Takeyoshi Tokuhara,Michael Drack,Reinhard Schwödiauer,Ingrid Graz,Simona Bauer-Gogonea,Siegfried Bauer,Takao Someya,Takao Someya +14 more
TL;DR: In this paper, the authors present a platform that makes electronics both virtually unbreakable and imperceptible on polyimide polysilicon elastomers, which can be operated at high temperatures and in aqueous environments.
Journal ArticleDOI
A review of wearable sensors and systems with application in rehabilitation.
Shyamal Patel,Shyamal Patel,Hyung-Kyu Park,Paolo Bonato,Paolo Bonato,Leighton Chan,Mary M. Rodgers,Mary M. Rodgers +7 more
TL;DR: In this paper, a review of wearable sensors and systems that are relevant to the field of rehabilitation is presented, focusing on health and wellness, safety, home rehabilitation, assessment of treatment efficacy, and early detection of disorders.
Journal ArticleDOI
Piezoelectricity of single-atomic-layer MoS2 for energy conversion and piezotronics.
Wenzhuo Wu,Lei Wang,Yilei Li,Fan Zhang,Long Lin,Simiao Niu,Daniel Chenet,Xian Zhang,Yufeng Hao,Tony F. Heinz,James Hone,Zhong Lin Wang +11 more
TL;DR: It is shown that cyclic stretching and releasing of thin MoS2 flakes with an odd number of atomic layers produces oscillating piezoelectric voltage and current outputs, whereas no output is observed for flakes with even number of layers, which may enable the development of applications in powering nanodevices, adaptive bioprobes and tunable/stretchable electronics/optoelectronics.
Journal ArticleDOI
Electrochemical Biosensors - Sensor Principles and Architectures
TL;DR: In this article, the most common traditional traditional techniques, such as cyclic voltammetry, chronoamperometry, chronopotentiometry, impedance spectroscopy, and various field-effect transistor based methods are presented along with selected promising novel approaches, including nanowire or magnetic nanoparticle-based biosensing.
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