Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
Wei Gao,Wei Gao,Sam Emaminejad,Sam Emaminejad,Sam Emaminejad,Hnin Yin Yin Nyein,Hnin Yin Yin Nyein,Samyuktha Challa,Kevin Chen,Kevin Chen,Austin J Peck,Hossain M. Fahad,Hossain M. Fahad,Hiroki Ota,Hiroki Ota,Hiroshi Shiraki,Hiroshi Shiraki,Daisuke Kiriya,Daisuke Kiriya,Der Hsien Lien,George A. Brooks,Ronald W. Davis,Ali Javey,Ali Javey +23 more
TLDR
This work bridges the technological gap between signal transduction, conditioning, processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.Abstract:
Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.read more
Citations
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Minimally-invasive Microneedle-based Biosensor Array for Simultaneous Lactate and Glucose Monitoring in Artificial Interstitial Fluid
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A Fully Integrated Wireless Flexible Ammonia Sensor Fabricated by Soft Nano-Lithography.
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Mechano-neuromodulation of autonomic pelvic nerve for underactive bladder: A triboelectric neurostimulator integrated with flexible neural clip interface
Sanghoon Lee,Hao Wang,Wendy Yen Xian Peh,Tianyiyi He,Shih-Cheng Yen,Nitish V. Thakor,Chengkuo Lee +6 more
TL;DR: Mechano-neuromodulation of autonomic pelvic nerves was demonstrated for the first time using a triboelectric neurostimulator integrated with flexible neural clip interface and chronic implantation of flexible clip interface with functionality test of the interface demonstrates that this technology may potentially be used for self-powered mechano-NEurommodulation for bladder function in the future.
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Self-powered multifunctional monitoring system using hybrid integrated triboelectric nanogenerators and piezoelectric microsensors
Changhe Sun,Qiongfeng Shi,Dihan Hasan,Mahmut Sami Yazici,Minglu Zhu,Yiming Ma,Bowei Dong,Yufei Liu,Chengkuo Lee +8 more
TL;DR: In this paper, a flexible multifunctional monitoring system with the integration of triboelectric nanogenerator (TENG) for energy harvesting, piezoelectoric micromachined ultrasonic transducer (pMUT) array and TENG sensor for simultaneous detection of multiple amenity parameters (i.e., temperature, relative humidity and CO2 concentration) has been developed.
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"Self-Matched" Tribo/Piezoelectric Nanogenerators Using Vapor-Induced Phase-Separated Poly(vinylidene fluoride) and Recombinant Spider Silk.
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