Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
Wei Gao,Wei Gao,Sam Emaminejad,Sam Emaminejad,Sam Emaminejad,Hnin Yin Yin Nyein,Hnin Yin Yin Nyein,Samyuktha Challa,Kevin Chen,Kevin Chen,Austin J Peck,Hossain M. Fahad,Hossain M. Fahad,Hiroki Ota,Hiroki Ota,Hiroshi Shiraki,Hiroshi Shiraki,Daisuke Kiriya,Daisuke Kiriya,Der Hsien Lien,George A. Brooks,Ronald W. Davis,Ali Javey,Ali Javey +23 more
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TLDR
This work bridges the technological gap between signal transduction, conditioning, processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.Abstract:
Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.read more
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Journal ArticleDOI
Wearable biosensors for healthcare monitoring.
TL;DR: Although wearable biosensors hold promise, a better understanding of the correlations between analyte concentrations in the blood and noninvasive biofluids is needed to improve reliability.
Journal ArticleDOI
Skin electronics from scalable fabrication of an intrinsically stretchable transistor array.
Sihong Wang,Jie Xu,Weichen Wang,Ging-Ji Nathan Wang,Reza Rastak,Francisco Molina-Lopez,Jong Won Chung,Jong Won Chung,Simiao Niu,Vivian R. Feig,Jeffery Lopez,Ting Lei,Soon-Ki Kwon,Yeongin Kim,Amir M. Foudeh,Anatol Ehrlich,Andrea Gasperini,Youngjun Yun,Youngjun Yun,Boris Murmann,Jeffery B.-H. Tok,Zhenan Bao +21 more
TL;DR: The process offers a general platform for incorporating other intrinsically stretchable polymer materials, enabling the fabrication of next-generation stretchable skin electronic devices, and demonstrates an intrinsicallyStretchable polymer transistor array with an unprecedented device density of 347 transistors per square centimetre.
Journal ArticleDOI
Lab-on-Skin: A Review of Flexible and Stretchable Electronics for Wearable Health Monitoring
TL;DR: The term "lab-on-skin" is introduced to describe a set of electronic devices that have physical properties, such as thickness, thermal mass, elastic modulus, and water-vapor permeability, which resemble those of the skin, which provide accurate, non-invasive, long-term, and continuous health monitoring.
Journal ArticleDOI
Skin-inspired highly stretchable and conformable matrix networks for multifunctional sensing
Qilin Hua,Junlu Sun,Haitao Liu,Rongrong Bao,Ruomeng Yu,Junyi Zhai,Caofeng Pan,Zhong Lin Wang,Zhong Lin Wang +8 more
TL;DR: A skin-inspired highly stretchable and conformable matrix network (SCMN) that successfully expands the e-skin sensing functionality including but not limited to temperature, in-plane strain, humidity, light, magnetic field, pressure, and proximity is presented.
Journal ArticleDOI
Electronic Skin: Recent Progress and Future Prospects for Skin‐Attachable Devices for Health Monitoring, Robotics, and Prosthetics
TL;DR: Recent progress in electronic skin or e‐skin research is broadly reviewed, focusing on technologies needed in three main applications: skin‐attachable electronics, robotics, and prosthetics.
References
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Tattoo-based noninvasive glucose monitoring: A proof-of-concept study
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Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring.
Amay J. Bandodkar,Denise Molinnus,Omar Mirza,Tomàs Guinovart,Joshua Ray Windmiller,Gabriela Valdés-Ramírez,Francisco J. Andrade,Michael J. Schöning,Joseph Wang +8 more
TL;DR: The favorable analytical performance along with the wearable nature of the wireless transceiver makes the new epidermal potentiometric sensing system attractive for continuous monitoring the sodium dynamics in human perspiration during diverse activities relevant to the healthcare, fitness, military, healthcare and skin-care domains.
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