Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
Wei Gao,Wei Gao,Sam Emaminejad,Sam Emaminejad,Sam Emaminejad,Hnin Yin Yin Nyein,Hnin Yin Yin Nyein,Samyuktha Challa,Kevin Chen,Kevin Chen,Austin J Peck,Hossain M. Fahad,Hossain M. Fahad,Hiroki Ota,Hiroki Ota,Hiroshi Shiraki,Hiroshi Shiraki,Daisuke Kiriya,Daisuke Kiriya,Der Hsien Lien,George A. Brooks,Ronald W. Davis,Ali Javey,Ali Javey +23 more
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TLDR
This work bridges the technological gap between signal transduction, conditioning, processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.Abstract:
Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.read more
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Journal ArticleDOI
Integrated Smart Janus Textile Bands for Self-Pumping Sweat Sampling and Analysis.
Xuecheng He,Shijie Yang,Quanbing Pei,Yongchao Song,Conghui Liu,Tailin Xu,Tailin Xu,Xueji Zhang,Xueji Zhang +8 more
TL;DR: An intelligent Janus textile band is introduced that bridges the gap between self-pumping sweat collection, comfortable epidemic microclimate and sensitive electrochemical biosensing via an integrated wearable platform and reveals that the sensitive detection of multiple biomarkers including glucose, lactate, K+ and Na+.
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Wearable-band type visible-near infrared optical biosensor for non-invasive blood glucose monitoring
TL;DR: A novel BG sensor is developed which is cost efficient and highly wearable with a small data acquisition time window that allow a non-invasive, long-term continuous blood glucose monitoring (CGM) system.
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Printable, Highly Sensitive Flexible Temperature Sensors for Human Body Temperature Monitoring: A Review
Yi Su,Chunsheng Ma,Jing Chen,Huiping Wu,Weixiang Luo,Yueming Peng,Zebang Luo,Lin Li,Yongsong Tan,Olatunji Mumini Omisore,Zhengfang Zhu,Lei Wang,Hui Li +12 more
TL;DR: The current research status of highly sensitive patterned flexible temperature sensors used to monitor body temperature changes are reviewed, including temperature measurement range, sensitivity, response time, temperature resolution, and the future challenges have prospected.
Journal ArticleDOI
Tissue-like skin-device interface for wearable bioelectronics by using ultrasoft, mass-permeable, and low-impedance hydrogels.
Chanhyuk Lim,Yongseok Joseph Hong,Jaebong Jung,Yoonsoo Shin,Sung-Hyuk Sunwoo,Seungmin Baik,Ok Kyu Park,Ok Kyu Park,Sueng Hong Choi,Sueng Hong Choi,Taeghwan Hyeon,Ji-Hoon Kim,Sang-Kyu Lee,Dae-Hyeong Kim +13 more
TL;DR: In this paper, an ultrathin type of functionalized hydrogel was used as a liquid electrolyte on the skin and formed an extremely conformal and low-impedance interface for wearable electrochemical biosensors and electrical stimulators.
Journal ArticleDOI
An ultraflexible organic differential amplifier for recording electrocardiograms
Masahiro Sugiyama,Masahiro Sugiyama,Takafumi Uemura,Takafumi Uemura,Masaya Kondo,Masaya Kondo,Mihoko Akiyama,Naoko Namba,Naoko Namba,Shusuke Yoshimoto,Yuki Noda,Teppei Araki,Teppei Araki,Tsuyoshi Sekitani,Tsuyoshi Sekitani +14 more
TL;DR: In this paper, a 2-μm-thick ultraflexible organic differential amplifier capable of processing physiological signals with high signal integrity and sensitivity is presented. But, substantial variations in OTFTs lead to the degradation of signal processing performance in circuits and restrict the development of organic differential amplifiers capable of recording weak physiological potentials.
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