Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
Wei Gao,Wei Gao,Sam Emaminejad,Sam Emaminejad,Sam Emaminejad,Hnin Yin Yin Nyein,Hnin Yin Yin Nyein,Samyuktha Challa,Kevin Chen,Kevin Chen,Austin J Peck,Hossain M. Fahad,Hossain M. Fahad,Hiroki Ota,Hiroki Ota,Hiroshi Shiraki,Hiroshi Shiraki,Daisuke Kiriya,Daisuke Kiriya,Der Hsien Lien,George A. Brooks,Ronald W. Davis,Ali Javey,Ali Javey +23 more
TLDR
This work bridges the technological gap between signal transduction, conditioning, processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.Abstract:
Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.read more
Citations
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Journal ArticleDOI
Engineering Precision Medicine.
TL;DR: Collective engineering efforts will help transform precision medicine into a more personalized and effective healthcare approach as continuous progress is made in engineering techniques.
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Long-term reliable physical health monitoring by sweat pore–inspired perforated electronic skins
Han-Wool Yeon,Han Eol Lee,Han Eol Lee,Yeongin Kim,Doyoon Lee,Young-Joo Lee,Jong-Sung Lee,Jiho Shin,Chanyeol Choi,Ji Hoon Kang,Jun Min Suh,Jun Min Suh,Hyunseok Kim,Hyun Kum,Jaeyong Lee,Daeyeon Kim,Kyul Ko,Boo Soo Ma,Peng Lin,Peng Lin,Sangwook Han,Sangwook Han,Sungkyu Kim,Sungkyu Kim,Sang-Hoon Bae,Taek-Soo Kim,Min-Chul Park,Young-Chang Joo,Eunjoo Kim,Jiyeon Han,Jeehwan Kim +30 more
TL;DR: In this article, a sweat pore-inspired perforated e-skin that can effectively suppress sweat accumulation and allow inorganic sensors to obtain physical health information without malfunctioning is presented.
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Skin-inspired electronics: emerging semiconductor devices and systems
TL;DR: Skin-inspired electronics have emerged as a new class of devices and systems for next-generation flexible and wearable electronics, which may find a broad range of applications in cutting-edge fields such as healthcare monitoring, human-machine interface, and soft robotics/prostheses.
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Nanomaterial‐Based Soft Electronics for Healthcare Applications
TL;DR: In this paper, the authors summarize recent advances in soft electronic devices for healthcare applications, including assembly methods for various nanomaterials, new device designs and integration strategies, their applications to textile-based and skin-attached wearable electronics, and their incorporation in fully and/or minimally invasive medical devices.
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Highly anisotropic and flexible piezoceramic kirigami for preventing joint disorders.
Ying Hong,Biao Wang,Weikang Lin,Lihan Jin,Shiyuan Liu,Xiaowei Luo,Jia Pan,Wenping Wang,Wenping Wang,Zhengbao Yang +9 more
TL;DR: In this article, a kirigami-structured highly anisotropic piezoelectric network composite sensor is proposed to monitor multiple information of joint motions, including bending direction, bending radius, and motion modes, and to distinguish them simultaneously within one sensor unit.
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