Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
Wei Gao,Wei Gao,Sam Emaminejad,Sam Emaminejad,Sam Emaminejad,Hnin Yin Yin Nyein,Hnin Yin Yin Nyein,Samyuktha Challa,Kevin Chen,Kevin Chen,Austin J Peck,Hossain M. Fahad,Hossain M. Fahad,Hiroki Ota,Hiroki Ota,Hiroshi Shiraki,Hiroshi Shiraki,Daisuke Kiriya,Daisuke Kiriya,Der Hsien Lien,George A. Brooks,Ronald W. Davis,Ali Javey,Ali Javey +23 more
TLDR
This work bridges the technological gap between signal transduction, conditioning, processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.Abstract:
Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.read more
Citations
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A wearable chemical-electrophysiological hybrid biosensing system for real-time health and fitness monitoring
Somayeh Imani,Amay J. Bandodkar,A. M. Vinu Mohan,Rajan Kumar,Shengfei Yu,Joseph Wang,Patrick P. Mercier +6 more
TL;DR: A skin-worn wearable hybrid sensing system that offers simultaneous real-time monitoring of a biochemical (lactate) and an electrophysiological signal (electrocardiogram) for more comprehensive fitness monitoring than from physical or electrophysics sensors alone.
Journal ArticleDOI
Self-powered ultra-flexible electronics via nano-grating-patterned organic photovoltaics.
Sungjun Park,Sungjun Park,Soo Won Heo,Wonryung Lee,Daishi Inoue,Zhi Jiang,Kilho Yu,Hiroaki Jinno,Hiroaki Jinno,Daisuke Hashizume,Masaki Sekino,Tomoyuki Yokota,Kenjiro Fukuda,Keisuke Tajima,Takao Someya,Takao Someya +15 more
TL;DR: Self-powered ultra-flexible electronic devices that can measure biometric signals with very high signal-to-noise ratios when applied to skin or other tissue are realized and offer a general platform for next-generation self-powered electronics.
Journal ArticleDOI
Flexible Electronics toward Wearable Sensing
TL;DR: A wearable and flexible sweat-sensing platform toward real-time multiplexed perspiration analysis is developed and an integrated iontophoresis module on a wearable sweat sensor could enable autonomous and programmed sweat extraction.
Journal ArticleDOI
Wearable Chemical Sensors: Present Challenges and Future Prospects
TL;DR: This perspective reviews key challenges and technological gaps impeding the successful realization of effective wearable chemical sensor systems, related to materials, power, analytical procedure, communication, data acquisition, processing, and security.
Journal ArticleDOI
A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat.
Yiran Yang,Yu Song,Yu Song,Xiangjie Bo,Jihong Min,On Shun Pak,Lailai Zhu,Min-Qiang Wang,Jiaobing Tu,Adam Kogan,Haixia Zhang,Tzung K. Hsiai,Zhaoping Li,Wei Gao +13 more
TL;DR: Continuous detection of temperature, respiration rate and low concentrations of uric acid and tyrosine, analytes associated with diseases such as gout and metabolic disorders are demonstrated with an entirely laser-engraved wearable sensor.
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