Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
Wei Gao,Wei Gao,Sam Emaminejad,Sam Emaminejad,Sam Emaminejad,Hnin Yin Yin Nyein,Hnin Yin Yin Nyein,Samyuktha Challa,Kevin Chen,Kevin Chen,Austin J Peck,Hossain M. Fahad,Hossain M. Fahad,Hiroki Ota,Hiroki Ota,Hiroshi Shiraki,Hiroshi Shiraki,Daisuke Kiriya,Daisuke Kiriya,Der Hsien Lien,George A. Brooks,Ronald W. Davis,Ali Javey,Ali Javey +23 more
Reads0
Chats0
TLDR
This work bridges the technological gap between signal transduction, conditioning, processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.Abstract:
Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.read more
Citations
More filters
Journal ArticleDOI
Fabrication of sharp silicon hollow microneedles by deep-reactive ion etching towards minimally invasive diagnostics
Yan Li,Hang Zhang,Ruifeng Yang,Yohan Laffitte,Ulises Schmill,Wenhan Hu,Moufeed Kaddoura,Eric J. M. Blondeel,Bo Cui +8 more
TL;DR: A team led by Bo Cui from University of Waterloo, and Eric Blondeel from ExVivo Labs Inc., demonstrates a modified deep reactive ion etching process for creating cone-shaped silicon microneedles with a hole opening for fluid extraction.
Journal ArticleDOI
Size‐Scalable and High‐Density Liquid‐Metal‐Based Soft Electronic Passive Components and Circuits Using Soft Lithography
TL;DR: In this paper, an advanced liquid metal thin-line patterning process based on soft lithography and a compatible vertical integration technique is presented that enable size-scalable and high-density EGaIn-based, soft microelectronic components and circuits.
Journal ArticleDOI
Wearable Devices for Precision Medicine and Health State Monitoring
TL;DR: This work reviews existing technologies currently used for measurement of the four primary vital signs: temperature, heart rate, respiration rate, and blood pressure, along with physical activity, sweat, and emotion.
Journal ArticleDOI
Recent advances and perspectives in sweat based wearable electrochemical sensors
A. M. Vinu Mohan,A. M. Vinu Mohan,Vinoth Rajendran,Vinoth Rajendran,Rupesh K. Mishra,Mathiyarasu Jayaraman,Mathiyarasu Jayaraman +6 more
TL;DR: A review of the challenges, perspectives, recent advances and the technological aspects in the progress of wearable electrochemical sweat sensors focused on electrochemical monitoring of various biomarkers from sweat samples.
Journal ArticleDOI
Epidermal Patch with Glucose Biosensor: pH and Temperature Correction toward More Accurate Sweat Analysis during Sport Practice
TL;DR: An epidermal patch for glucose analysis in sweat incorporating for the first time pH and temperature correction according to local dynamic fluctuations in sweat during on-body tests, revealing a great potential of the wearable glucose sensor toward the provision of reliable physiological data linked to individuals during sport activity.
References
More filters
Journal ArticleDOI
Skin-like pressure and strain sensors based on transparent elastic films of carbon nanotubes
Darren J. Lipomi,Michael Vosgueritchian,Benjamin C. K. Tee,Sondra L. Hellstrom,Jennifer A. Lee,Courtney H. Fox,Zhenan Bao +6 more
TL;DR: Transparent, conducting spray-deposited films of single-walled carbon nanotubes are reported that can be rendered stretchable by applying strain along each axis, and then releasing this strain.
Journal ArticleDOI
An ultra-lightweight design for imperceptible plastic electronics
Martin Kaltenbrunner,Tsuyoshi Sekitani,Tsuyoshi Sekitani,Jonathan T. Reeder,Jonathan T. Reeder,Tomoyuki Yokota,Kazunori Kuribara,Takeyoshi Tokuhara,Michael Drack,Reinhard Schwödiauer,Ingrid Graz,Simona Bauer-Gogonea,Siegfried Bauer,Takao Someya,Takao Someya +14 more
TL;DR: In this paper, the authors present a platform that makes electronics both virtually unbreakable and imperceptible on polyimide polysilicon elastomers, which can be operated at high temperatures and in aqueous environments.
Journal ArticleDOI
A review of wearable sensors and systems with application in rehabilitation.
Shyamal Patel,Shyamal Patel,Hyung-Kyu Park,Paolo Bonato,Paolo Bonato,Leighton Chan,Mary M. Rodgers,Mary M. Rodgers +7 more
TL;DR: In this paper, a review of wearable sensors and systems that are relevant to the field of rehabilitation is presented, focusing on health and wellness, safety, home rehabilitation, assessment of treatment efficacy, and early detection of disorders.
Journal ArticleDOI
Piezoelectricity of single-atomic-layer MoS2 for energy conversion and piezotronics.
Wenzhuo Wu,Lei Wang,Yilei Li,Fan Zhang,Long Lin,Simiao Niu,Daniel Chenet,Xian Zhang,Yufeng Hao,Tony F. Heinz,James Hone,Zhong Lin Wang +11 more
TL;DR: It is shown that cyclic stretching and releasing of thin MoS2 flakes with an odd number of atomic layers produces oscillating piezoelectric voltage and current outputs, whereas no output is observed for flakes with even number of layers, which may enable the development of applications in powering nanodevices, adaptive bioprobes and tunable/stretchable electronics/optoelectronics.
Journal ArticleDOI
Electrochemical Biosensors - Sensor Principles and Architectures
TL;DR: In this article, the most common traditional traditional techniques, such as cyclic voltammetry, chronoamperometry, chronopotentiometry, impedance spectroscopy, and various field-effect transistor based methods are presented along with selected promising novel approaches, including nanowire or magnetic nanoparticle-based biosensing.
Related Papers (5)
A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat
Ahyeon Koh,Daeshik Kang,Daeshik Kang,Yeguang Xue,Seungmin Lee,Rafal M. Pielak,Jeonghyun Kim,Jeonghyun Kim,Taehwan Hwang,Seunghwan Min,Anthony Banks,Philippe Bastien,Megan Manco,Liang Wang,Liang Wang,Kaitlyn R. Ammann,Kyung In Jang,Phillip Won,Seungyong Han,Roozbeh Ghaffari,Ungyu Paik,Marvin J. Slepian,Guive Balooch,Yonggang Huang,John A. Rogers +24 more