Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
Wei Gao,Wei Gao,Sam Emaminejad,Sam Emaminejad,Sam Emaminejad,Hnin Yin Yin Nyein,Hnin Yin Yin Nyein,Samyuktha Challa,Kevin Chen,Kevin Chen,Austin J Peck,Hossain M. Fahad,Hossain M. Fahad,Hiroki Ota,Hiroki Ota,Hiroshi Shiraki,Hiroshi Shiraki,Daisuke Kiriya,Daisuke Kiriya,Der Hsien Lien,George A. Brooks,Ronald W. Davis,Ali Javey,Ali Javey +23 more
TLDR
This work bridges the technological gap between signal transduction, conditioning, processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.Abstract:
Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.read more
Citations
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Multiscale porous elastomer substrates for multifunctional on-skin electronics with passive-cooling capabilities
Yadong Xu,Bohan Sun,Yun Ling,Qihui Fei,Zanyu Chen,Xiaopeng Li,Peijun Guo,Nari Jeon,Shivam Goswami,Yixuan Liao,Shinghua Ding,Qingsong Yu,Jian Lin,Guoliang Huang,Zheng Yan +14 more
TL;DR: The development of multifunctional on-skin electronics, which can passively cool human bodies without needing any energy consumption is reported, inherited from multiscale porous polystyrene-block- poly(ethylene-ran-butylene)-block-polystyrene (SEBS) supporting substrates.
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High Performance Humidity Fluctuation Sensor for Wearable Devices via a Bioinspired Atomic-Precise Tunable Graphene-Polymer Heterogeneous Sensing Junction
Jiang He,Peng Xiao,Jiangwei Shi,Yun Liang,Wei Lu,Yousi Chen,Wenqin Wang,Patrick Theato,Shiao-Wei Kuo,Tao Chen +9 more
TL;DR: In this article, a novel sensing mechanism based on dynamical hydrogen bonds is proposed to record humidity fluctuation information in real-time during a user's speech and breath, which can both reveal the speech feature and reveal the biological information in a noninvasive way.
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Highly stretchable and self-healing strain sensors for motion detection in wireless human-machine interface
Cheng-Zhou Hang,Xue-Feng Zhao,Xue-Feng Zhao,Song-Yan Xi,Yinghui Shang,Kaiping Yuan,Fan Yang,Qigang Wang,Jiacheng Wang,David Wei Zhang,Hong-Liang Lu +10 more
TL;DR: In this article, a strain sensor with high stretchability and sensitivity is designed and fabricated based on the poly(acrylamide) (PAAm) hydrogel for motion detection in fields such as robotics and human-machine interface.
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Flexible Electronics and Devices as Human–Machine Interfaces for Medical Robotics
TL;DR: In this paper , the fundamental components of the materials, structures, and mechanisms in flexible human-machine interfaces are summarized by recent and renowned applications in five primary areas: physical and chemical sensing, physiological recording, information processing and communication, soft robotic actuation, and feedback stimulation.
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A wearable, cotton thread/paper-based microfluidic device coupled with smartphone for sweat glucose sensing
TL;DR: A wearable μTPAD containing a cotton thread and a functionalized filter paper for non-invasive, quantitative and in situ monitoring of human sweat glucose with the assistance of a smartphone is developed.
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