Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
Wei Gao,Wei Gao,Sam Emaminejad,Sam Emaminejad,Sam Emaminejad,Hnin Yin Yin Nyein,Hnin Yin Yin Nyein,Samyuktha Challa,Kevin Chen,Kevin Chen,Austin J Peck,Hossain M. Fahad,Hossain M. Fahad,Hiroki Ota,Hiroki Ota,Hiroshi Shiraki,Hiroshi Shiraki,Daisuke Kiriya,Daisuke Kiriya,Der Hsien Lien,George A. Brooks,Ronald W. Davis,Ali Javey,Ali Javey +23 more
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TLDR
This work bridges the technological gap between signal transduction, conditioning, processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.Abstract:
Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.read more
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Journal ArticleDOI
Wearable Sensor System for Detection of Lactate in Sweat.
Luke J. Currano,F. Connor Sage,Matthew Hagedon,Leslie Hamilton,Julia B. Patrone,Konstantinos Gerasopoulos +5 more
TL;DR: A wearable sensor system for non-invasive detection of excreted human biomarkers in sweat that is designed such that the sensing element plugs into a low-profile socket, and can easily be removed and replaced as needed due to saturation or aging effects.
Journal ArticleDOI
Wearable Sweatband Sensor Platform Based on Gold Nanodendrite Array as Efficient Solid Contact of Ion-Selective Electrode
Shuqi Wang,Yongjin Wu,Yang Gu,Tie Li,Hui Luo,Lianhui Li,Yuanyuan Bai,Lili Li,Lin Liu,Yudong Cao,Ding Haiyan,Ting Zhang +11 more
TL;DR: A wearable sensor platform with a new type of all-solid-state ISE based on a gold nanodendrite (AuND) array electrode as the solid contact and a poly(vinyl acetate)/inorganic salt (PVA/KCl) membrane-coated all- Solid State ISE and reference electrode (RE) platform with simplicity and stability is proposed.
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Flexible inorganic bioelectronics
TL;DR: This review covers recent progresses in flexible inorganic bio-electronics for human physiological parameters’ monitoring in a wearable and continuous way and strategies including materials, structures and device design are introduced with highlights toward the ability to solve remaining challenges in the measurement process.
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A self-sustainable wearable multi-modular E-textile bioenergy microgrid system.
Lu Yin,Kyeong Nam Kim,Jian Lv,Farshad Tehrani,Muyang Lin,Zuzeng Lin,Jong-Min Moon,Jessica Ma,Jialu Yu,Sheng Xu,Joseph Wang +10 more
TL;DR: In this paper, a textile-based bioenergy microgrid is proposed for wearable devices, which relies solely on human activity to work synergistically, harvesting biochemical and biomechanical energy using sweatbased biofuel cells and triboelectric generators.
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Artificial intelligence biosensors: Challenges and prospects.
TL;DR: The most advanced progress made in the key phases for future wearable and implantable technology from biosensing, wearable biosensing to AI-biosensing is summarized and material innovation, biorecognition element, signal acquisition and transportation, data processing and intelligence decision system are the most important parts.
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