Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
Wei Gao,Wei Gao,Sam Emaminejad,Sam Emaminejad,Sam Emaminejad,Hnin Yin Yin Nyein,Hnin Yin Yin Nyein,Samyuktha Challa,Kevin Chen,Kevin Chen,Austin J Peck,Hossain M. Fahad,Hossain M. Fahad,Hiroki Ota,Hiroki Ota,Hiroshi Shiraki,Hiroshi Shiraki,Daisuke Kiriya,Daisuke Kiriya,Der Hsien Lien,George A. Brooks,Ronald W. Davis,Ali Javey,Ali Javey +23 more
TLDR
This work bridges the technological gap between signal transduction, conditioning, processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.Abstract:
Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.read more
Citations
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Wearable biosensor for sensitive detection of uric acid in artificial sweat enabled by a fiber structured sensing interface
TL;DR: Wang et al. as mentioned in this paper reported a flexible sweat biosensor for uric acid detection based on a fiber structured sensing interface The electrospun carbon nanofibers with rich active sites, oriented graphitized layer, and intrinsic shape-adaptivity provide abundant access to uric acids molecules and enable efficient electron transmission.
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Construction of Bio-Piezoelectric Platforms: From Structures and Synthesis to Applications
Qianqian Xu,Xinyu Gao,Senfeng Zhao,You-Nian Liu,Dou Zhang,Kechao Zhou,Hamideh Khanbareh,Wansong Chen,Yan Zhang,Christopher R. Bowen +9 more
TL;DR: In this article, a review of the development of bio-piezoelectric platforms from a broad perspective and highlights their design and engineering strategies is presented. And the relationships between the properties, structure, and biomedical performance of the bio-poelectrics are examined to provide a deep understanding of the working mechanisms in a physiological environment.
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An ultrasensitive strain sensor with a wide strain range based on graphene armour scales
Yang Yifan,Lu-Qi Tao,Yu Pang,He Tian,Zhen-Yi Ju,Xiaoming Wu,Yi Yang,Tian-Ling Ren,Tian-Ling Ren +8 more
TL;DR: This ultrasensitive strain sensor with a wide strain range based on graphene armour scales can meet the demands of subtle, large and complex human motion monitoring, which indicates its tremendous application potential in health monitoring, mechanical control, real-time motion monitoring and so on.
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A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure.
Joohee Kim,Jihun Park,Young Geun Park,Young Geun Park,Eunkyung Cha,Minjae Ku,Hyeon Seok An,Kyoung-Pil Lee,Man-Il Huh,Junmo Kim,Taek-Soo Kim,Dai Woo Kim,Hong Kyun Kim,Jang Ung Park +13 more
TL;DR: In this paper, a soft and transparent contact lens for the quantitative monitoring of intraocular pressure (IOP) in real time using a smartphone was proposed, and tested in humans and rabbits.
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Stretchable and Self-Healable Conductive Hydrogels for Wearable Multimodal Touch Sensors with Thermoresponsive Behavior.
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