Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
Wei Gao,Wei Gao,Sam Emaminejad,Sam Emaminejad,Sam Emaminejad,Hnin Yin Yin Nyein,Hnin Yin Yin Nyein,Samyuktha Challa,Kevin Chen,Kevin Chen,Austin J Peck,Hossain M. Fahad,Hossain M. Fahad,Hiroki Ota,Hiroki Ota,Hiroshi Shiraki,Hiroshi Shiraki,Daisuke Kiriya,Daisuke Kiriya,Der Hsien Lien,George A. Brooks,Ronald W. Davis,Ali Javey,Ali Javey +23 more
TLDR
This work bridges the technological gap between signal transduction, conditioning, processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing.Abstract:
Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.read more
Citations
More filters
Journal ArticleDOI
3D Crumpled Ultrathin 1T MoS2 for Inkjet Printing of Mg-Ion Asymmetric Micro-supercapacitors.
Yuanlong Shao,Yuanlong Shao,Jui-Han Fu,Zhen Cao,Kepeng Song,Ruofan Sun,Yi Wan,Atif Shamim,Luigi Cavallo,Yu Han,Richard B. Kaner,Vincent Tung +11 more
TL;DR: 3D 1T c-MoS2 enables an extended electrochemical stable working potential range and enhanced capacitive performance in a bivalent magnesium-ion aqueous electrolyte and highlights the promise of 3D layered materials as well-dispersed functional materials for large-scale printed flexible energy storage devices.
Journal ArticleDOI
Enhancement-Mode PEDOT:PSS Organic Electrochemical Transistors Using Molecular De-Doping
Scott T. Keene,Tom P. A. van der Pol,Dante Zakhidov,C. H. L. Weijtens,René A. J. Janssen,Alberto Salleo,Yoeri van de Burgt +6 more
TL;DR: The enhancement-mode OECTs show mobilities near that of pristine PEDOT:PSS (≈2 cm2 V-1 s-1 ) with stable operation over 1000 on/off cycles and the underlying chemical mechanism of the threshold voltage shift to negative voltages is characterized.
Journal ArticleDOI
Wearable potentiometric tattoo biosensor for on-body detection of G-type nerve agents simulants
Rupesh K. Mishra,Abbas Barfidokht,Aleksandar Karajić,Juliane R. Sempionatto,Joshua Wang,Joseph Wang +5 more
TL;DR: The attractive performance of the new wearable OP potentiometric tattoo biosensor indicates considerable promise for on-body threat detection towards rapid warning regarding potential exposure to G-series nerve agents.
Journal ArticleDOI
An efficient PEDOT-coated textile for wearable thermoelectric generators and strain sensors
Yanhua Jia,Lanlan Shen,Jing Liu,Weiqiang Zhou,Yukou Du,Jingkun Xu,Jingkun Xu,Congcong Liu,Ge Zhang,Zhang Zishan,Fengxing Jiang +10 more
TL;DR: In this paper, the authors proposed an efficient strategy for the fabrication of a highly conductive commercial textile coated with poly(3,4-ethylenedioxythiophene) (PEDOT) via vapor phase polymerization (VPP) as a wearable thermoelectric (TE) strain sensor.
Journal ArticleDOI
Smart Insole for Robust Wearable Biomechanical Energy Harvesting in Harsh Environments
Zhihao Zhou,Zhihao Zhou,Lei Weng,Trinny Tat,Alberto Libanori,Zhiming Lin,Leijiao Ge,Jin Yang,Jun Chen +8 more
TL;DR: A waterproof smart insole, based on a triboelectric nanogenerator, for highly efficient and robust human biomechanical energy harvesting, and able to withstand use in harsh environments, without affecting the power output consistency.
References
More filters
Journal ArticleDOI
Skin-like pressure and strain sensors based on transparent elastic films of carbon nanotubes
Darren J. Lipomi,Michael Vosgueritchian,Benjamin C. K. Tee,Sondra L. Hellstrom,Jennifer A. Lee,Courtney H. Fox,Zhenan Bao +6 more
TL;DR: Transparent, conducting spray-deposited films of single-walled carbon nanotubes are reported that can be rendered stretchable by applying strain along each axis, and then releasing this strain.
Journal ArticleDOI
An ultra-lightweight design for imperceptible plastic electronics
Martin Kaltenbrunner,Tsuyoshi Sekitani,Tsuyoshi Sekitani,Jonathan T. Reeder,Jonathan T. Reeder,Tomoyuki Yokota,Kazunori Kuribara,Takeyoshi Tokuhara,Michael Drack,Reinhard Schwödiauer,Ingrid Graz,Simona Bauer-Gogonea,Siegfried Bauer,Takao Someya,Takao Someya +14 more
TL;DR: In this paper, the authors present a platform that makes electronics both virtually unbreakable and imperceptible on polyimide polysilicon elastomers, which can be operated at high temperatures and in aqueous environments.
Journal ArticleDOI
A review of wearable sensors and systems with application in rehabilitation.
Shyamal Patel,Shyamal Patel,Hyung-Kyu Park,Paolo Bonato,Paolo Bonato,Leighton Chan,Mary M. Rodgers,Mary M. Rodgers +7 more
TL;DR: In this paper, a review of wearable sensors and systems that are relevant to the field of rehabilitation is presented, focusing on health and wellness, safety, home rehabilitation, assessment of treatment efficacy, and early detection of disorders.
Journal ArticleDOI
Piezoelectricity of single-atomic-layer MoS2 for energy conversion and piezotronics.
Wenzhuo Wu,Lei Wang,Yilei Li,Fan Zhang,Long Lin,Simiao Niu,Daniel Chenet,Xian Zhang,Yufeng Hao,Tony F. Heinz,James Hone,Zhong Lin Wang +11 more
TL;DR: It is shown that cyclic stretching and releasing of thin MoS2 flakes with an odd number of atomic layers produces oscillating piezoelectric voltage and current outputs, whereas no output is observed for flakes with even number of layers, which may enable the development of applications in powering nanodevices, adaptive bioprobes and tunable/stretchable electronics/optoelectronics.
Journal ArticleDOI
Electrochemical Biosensors - Sensor Principles and Architectures
TL;DR: In this article, the most common traditional traditional techniques, such as cyclic voltammetry, chronoamperometry, chronopotentiometry, impedance spectroscopy, and various field-effect transistor based methods are presented along with selected promising novel approaches, including nanowire or magnetic nanoparticle-based biosensing.
Related Papers (5)
A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat
Ahyeon Koh,Daeshik Kang,Daeshik Kang,Yeguang Xue,Seungmin Lee,Rafal M. Pielak,Jeonghyun Kim,Jeonghyun Kim,Taehwan Hwang,Seunghwan Min,Anthony Banks,Philippe Bastien,Megan Manco,Liang Wang,Liang Wang,Kaitlyn R. Ammann,Kyung In Jang,Phillip Won,Seungyong Han,Roozbeh Ghaffari,Ungyu Paik,Marvin J. Slepian,Guive Balooch,Yonggang Huang,John A. Rogers +24 more