GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF
Shuqian Jing,Duanzhi Wen,Yanbin Yu,Paige Holst,Yi Luo,Mei Fang,Rami Tamir,Laarni Antonio,Zheng Hu,Rod Cupples,Jean-Claude Louis,Sylvia Hu,Bruce W. Altrock,Gary M. Fox +13 more
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TLDR
In this paper, the expression cloning and characterization of GDNFR-α, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF), was reported.About:
This article is published in Cell.The article was published on 1996-06-28 and is currently open access. It has received 1164 citations till now. The article focuses on the topics: Glial cell line-derived neurotrophic factor & GDNF family of ligands.read more
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Improved survival of embryonic porcine dopaminergic neurons in coculture with a conditionally immortalized GDNF-producing hippocampal cell line.
TL;DR: In conclusion, the better survival of HiB5-GDNF cocultures is promising for the generation of effective cell lines for local delivery of neurotrophic factors to intracerebral nigral grafts.
Book ChapterDOI
Directions in Cell Migration Along the Rostral Migratory Stream: The Pathway for Migration in the Brain
Shin-ichi Murase,Alan F. Horwitz +1 more
TL;DR: The nature of the migrations and the putative molecular players are reviewed and the molecular mechanisms controlling the migration are now beginning to emerge.
Journal ArticleDOI
Glial cell line-derived neurotrophic factor induces cell migration in human oral squamous cell carcinoma.
Jing-Yuan Chuang,Cheng-Fang Tsai,Shu-Wen Chang,I-Ping Chiang,Ssu-Ming Huang,Hsiao-Yun Lin,Wei-Lan Yeh,Dah-Yuu Lu +7 more
TL;DR: It is found that application of human GDNF enhanced the cell migration ability of human oral cancers and indicates a regulatory effect on cell migration by GDNF in oral squamous cancer.
Journal ArticleDOI
Neurotrophic factors BDNF and GDNF protect embryonic chick spinal cord motoneurons from ethanol neurotoxicity in vivo
TL;DR: This study represents the first demonstration of in vivo neuroprotection from ethanol toxicity with respect to specific neuronal populations, and analysis of motoneuron numbers indicated that both BDNF and GDNF provided protection to developing spinal cord motoneurons from ethanoloxicity, restoring mot oneuron numbers to control levels.
Journal ArticleDOI
Update on the profile of multiple endocrine neoplasia type 2a RET mutations
TL;DR: The sensitivity of genetic screening for MEN 2a offered by diagnostic laboratories that limit RET analysis to exons 10 and 11 is 82.8% with a sensitivity approaching 95% as discussed by the authors.
References
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Book
Antibodies: A Laboratory Manual
Ed Harlow,David P. Lane +1 more
TL;DR: A second edition of Antibodies: A Laboratory Manual is being published in September 2013, Revised, extended and updated by Edward Greenfield of the Dana-Farber Cancer Center, the material has been recast with extensive new information and new chapters have been added.
Journal ArticleDOI
Improved tools for biological sequence comparison.
TL;DR: Three computer programs for comparisons of protein and DNA sequences can be used to search sequence data bases, evaluate similarity scores, and identify periodic structures based on local sequence similarity.
Journal ArticleDOI
Signal transduction by receptors with tyrosine kinase activity
Axel Ullrich,Joseph Schlessinger +1 more
TL;DR: Cet article synthese montre comment des recepteurs membranaires a activite tyrosine kinase peuvent etre impliques dans la transduction and notamment jouent le role de signal de the transduction.
Journal ArticleDOI
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
TL;DR: 5'-Noncoding sequences have been compiled from 699 vertebrate mRNAs and GCCA/GCCATGG emerges as the consensus sequence for initiation of translation in vertebrates.
Journal ArticleDOI
A new method for predicting signal sequence cleavage sites.
TL;DR: A new method for identifying secretory signal sequences and for predicting the site of cleavage between a signal sequence and the mature exported protein is described.
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