GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF
Shuqian Jing,Duanzhi Wen,Yanbin Yu,Paige Holst,Yi Luo,Mei Fang,Rami Tamir,Laarni Antonio,Zheng Hu,Rod Cupples,Jean-Claude Louis,Sylvia Hu,Bruce W. Altrock,Gary M. Fox +13 more
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TLDR
In this paper, the expression cloning and characterization of GDNFR-α, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF), was reported.About:
This article is published in Cell.The article was published on 1996-06-28 and is currently open access. It has received 1164 citations till now. The article focuses on the topics: Glial cell line-derived neurotrophic factor & GDNF family of ligands.read more
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Gas1 Is Related to the Glial Cell-derived Neurotrophic Factor Family Receptors α and Regulates Ret Signaling
J. Ruben Cabrera,Luis Sanchez-Pulido,Ana M. Rojas,Alfonso Valencia,Santos Mañes,Jose R. Naranjo,Britt Mellström +6 more
TL;DR: It is demonstrated that the Gas1 protein shows high structural similarity to the glial cell-derived neurotrophic factor (GDNF) family receptors α, which mediate GDNF responses through the receptor tyrosine kinase Ret, and binds Ret in a ligand-independent manner and sequesters Ret in lipid rafts.
Journal ArticleDOI
Structure-function analysis of the EGF-CFC family member Cripto identifies residues essential for nodal signalling
Gabriella Minchiotti,Giuseppe Manco,Silvia Parisi,C. T. Lago,Frédéric M. Rosa,M. Graziella Persico +5 more
TL;DR: This study shows that injection of Cripto recombinant protein in mid to late zebrafish Maternal-Zygotic one-eyed pinhead (MZoep) blastulae was able to fully rescue the mutant phenotype, thus providing the first direct evidence that Cripte activity can be added extracellularly to recover oep-encoded function in zebra fish early embryos.
Journal ArticleDOI
The genetics of neuroendocrine tumors.
TL;DR: Genome-wide screening of different types ofNETs can now be performed for a reasonable price and is likely to generate new insights into the tumor biology and carcinogenesis in various subtypes of NETs.
Journal ArticleDOI
Molecular signaling and pulpal nerve development.
TL;DR: Nerve growth factor and possibly also brain-derived neurotrophic factor seem to be important in the formation of a sensory pulpal innervation, but Neurotrophin-3 and -4/5 are probably not involved and glial cell line- derived neurotrophic factors seems to be involved in the control of pulpal axon growth.
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Hirschsprung's disease: genetic and functional associations of Down's and Waardenburg syndromes.
Samuel W. Moore,A.G. Johnson +1 more
TL;DR: The genetic aspects of HD occurring in association with trisomy 21 and WS are reviewed, and an increased susceptibility to severe enterocolitis associated with a high mortality rate is reported.
References
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TL;DR: A second edition of Antibodies: A Laboratory Manual is being published in September 2013, Revised, extended and updated by Edward Greenfield of the Dana-Farber Cancer Center, the material has been recast with extensive new information and new chapters have been added.
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TL;DR: Cet article synthese montre comment des recepteurs membranaires a activite tyrosine kinase peuvent etre impliques dans la transduction and notamment jouent le role de signal de the transduction.
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