GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF
Shuqian Jing,Duanzhi Wen,Yanbin Yu,Paige Holst,Yi Luo,Mei Fang,Rami Tamir,Laarni Antonio,Zheng Hu,Rod Cupples,Jean-Claude Louis,Sylvia Hu,Bruce W. Altrock,Gary M. Fox +13 more
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TLDR
In this paper, the expression cloning and characterization of GDNFR-α, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF), was reported.About:
This article is published in Cell.The article was published on 1996-06-28 and is currently open access. It has received 1164 citations till now. The article focuses on the topics: Glial cell line-derived neurotrophic factor & GDNF family of ligands.read more
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The molecular basis of retinal ganglion cell death in glaucoma.
Mohammadali Almasieh,Ariel M. Wilson,Barbara Morquette,Jorge L. Cueva Vargas,Adriana Di Polo +4 more
TL;DR: This body of work has considerably updated and expanded the view of how RGCs might die in glaucoma and has revealed novel, potential targets for neuroprotection.
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Interleukin 6 and its receptor: ten years later.
TL;DR: JAK tyrosine kinase is a key molecule that can initiate multiple signal-transduction pathways by inducing the tyrosinesine-phosphorylation of the cytokine receptor, gp130 in the case of IL-6, on which several signaling molecules are recruited, including STAT, a signal transducer and activator of transcription, and SHP-2, which links to the Ras-MAP kinase pathway.
Journal ArticleDOI
Neurturin, a relative of glial-cell-line-derived neurotrophic factor.
Paul T. Kotzbauer,Patricia A. Lampe,Robert O. Heuckeroth,Judith P. Golden,Douglas J. Creedon,Eugene M. Johnson,Jeffrey Milbrandt +6 more
TL;DR: Neurturin and Glial Cell Line-derived neurotrophic factor (GDNF) as discussed by the authors have been shown to activate the MAP kinase signalling pathway in cultured sympathetic neurons and support the survival of sympathetic neurons, as well as of sensory neurons of nodose and dorsal root ganglia.
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The EGF-CFC Protein One-Eyed Pinhead Is Essential for Nodal Signaling
Kira Gritsman,Jiaojiao Zhang,Simon Cheng,Elizabeth Heckscher,William S. Talbot,Alexander F. Schier +5 more
TL;DR: It is reported that embryos lacking both maternal and zygotic Oep activity are defective in germ layer formation, organizer development, and the positioning of the anterior-posterior axis.
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Peripheral nerve regeneration and neurotrophic factors
TL;DR: The studies reviewed in this article show the therapeutic potential of neurotrophic factors for the treatment of peripheral nerve injury and for neuropathies.
References
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Book
Antibodies: A Laboratory Manual
Ed Harlow,David P. Lane +1 more
TL;DR: A second edition of Antibodies: A Laboratory Manual is being published in September 2013, Revised, extended and updated by Edward Greenfield of the Dana-Farber Cancer Center, the material has been recast with extensive new information and new chapters have been added.
Journal ArticleDOI
Improved tools for biological sequence comparison.
TL;DR: Three computer programs for comparisons of protein and DNA sequences can be used to search sequence data bases, evaluate similarity scores, and identify periodic structures based on local sequence similarity.
Journal ArticleDOI
Signal transduction by receptors with tyrosine kinase activity
Axel Ullrich,Joseph Schlessinger +1 more
TL;DR: Cet article synthese montre comment des recepteurs membranaires a activite tyrosine kinase peuvent etre impliques dans la transduction and notamment jouent le role de signal de the transduction.
Journal ArticleDOI
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
TL;DR: 5'-Noncoding sequences have been compiled from 699 vertebrate mRNAs and GCCA/GCCATGG emerges as the consensus sequence for initiation of translation in vertebrates.
Journal ArticleDOI
A new method for predicting signal sequence cleavage sites.
TL;DR: A new method for identifying secretory signal sequences and for predicting the site of cleavage between a signal sequence and the mature exported protein is described.
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