GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF
Shuqian Jing,Duanzhi Wen,Yanbin Yu,Paige Holst,Yi Luo,Mei Fang,Rami Tamir,Laarni Antonio,Zheng Hu,Rod Cupples,Jean-Claude Louis,Sylvia Hu,Bruce W. Altrock,Gary M. Fox +13 more
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TLDR
In this paper, the expression cloning and characterization of GDNFR-α, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF), was reported.About:
This article is published in Cell.The article was published on 1996-06-28 and is currently open access. It has received 1164 citations till now. The article focuses on the topics: Glial cell line-derived neurotrophic factor & GDNF family of ligands.read more
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A Novel Case of Multiple Endocrine Neoplasia Type 2A Associated with Two de Novo Mutations of the RET Protooncogene
Alessandra Tessitore,Antonio Agostino Sinisi,Daniela Pasquali,Monica Cardone,Domenico Vitale,Antonio Bellastella,Vittorio Colantuoni,Vittorio Colantuoni +7 more
TL;DR: A novel case of multiple endocrine neoplasia type 2A (MEN 2A) associated with two mutations of the protooncogene RET, present on the same RET allele and associated with a calcitonin-producing pheochromocytoma is reported.
Journal ArticleDOI
Brain-derived growth factor and glial cell line-derived growth factor use distinct intracellular signaling pathways to protect PD cybrids from H2O2-induced neuronal death
TL;DR: Results demonstrate that expression of PD mitochondrial genes in cybrids increases vulnerability to oxidative stress that is ameliorated by both BDNF and GDNF, which utilize distinct signaling cascades to increase intracellular GSH and enhance survival-promoting cell signaling.
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Intrastriatal grafting of a GDNF-producing cell line protects striatonigral neurons from quinolinic acid excitotoxicity in vivo.
TL;DR: The findings show that GDNF selectively regulates the phenotype and protects striatonigral neurons from QUIN‐induced excitotoxicity, suggesting thatGDNF may be used for the treatment of striatonIGral degenerative disorders, e.g. Huntington's disease and multiple system atrophy.
Journal ArticleDOI
Structural studies of GDNF family ligands with their receptors-Insights into ligand recognition and activation of receptor tyrosine kinase RET.
TL;DR: Current understanding of the molecular basis underlying ligand recognition and activation of RET is summarized, focusing on the interactions of GFLs with their respective GFRα receptors, the recently determined crystal structure of RET extracellular region and a proposed GFL-GFRα-RET ternary complex model based on extensive structural, biochemical and functional data.
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GDNF, Ret, GFRalpha1 and 2 in the adult rat retino-tectal system after optic nerve transection.
TL;DR: A function for GDNF locally in the retina and as part of an injury-induced system that may act to enhance neuroprotective and neuroregenerative responses both to endogenous GDNF ligands and those administered exogenously are supported.
References
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TL;DR: A second edition of Antibodies: A Laboratory Manual is being published in September 2013, Revised, extended and updated by Edward Greenfield of the Dana-Farber Cancer Center, the material has been recast with extensive new information and new chapters have been added.
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