GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF
Shuqian Jing,Duanzhi Wen,Yanbin Yu,Paige Holst,Yi Luo,Mei Fang,Rami Tamir,Laarni Antonio,Zheng Hu,Rod Cupples,Jean-Claude Louis,Sylvia Hu,Bruce W. Altrock,Gary M. Fox +13 more
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TLDR
In this paper, the expression cloning and characterization of GDNFR-α, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF), was reported.About:
This article is published in Cell.The article was published on 1996-06-28 and is currently open access. It has received 1164 citations till now. The article focuses on the topics: Glial cell line-derived neurotrophic factor & GDNF family of ligands.read more
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Potential role of glial cell line-derived neurotrophic factor receptors in Müller glial cells during light-induced retinal degeneration
C Harada,T Harada,H.-M.A Quah,Fumihiko Maekawa,Kazuhiko Yoshida,Shigeaki Ohno,Keiji Wada,Luis F. Parada,Kohichi Tanaka +8 more
TL;DR: Observations suggest that GDNF, NTN and their receptors are involved in the regulation of trophic factor production in retinal glial cells, and that functional glia-neuron network may utilize GDNF family for the protection of neural cells during retinal degeneration.
Journal Article
Behavioral and Neurochemical Effects of Intranigral Administration of Glial Cell Line-Derived Neurotrophic Factor on Aged Fischer 344 Rats
TL;DR: Results indicate that a single intranigral injection of GDNF is capable of augmenting locomotor behavior and DAergic function in the aged rat striatum and nucleus accumbens.
Journal ArticleDOI
The Caenorhabditis elegans odr-2 gene encodes a novel Ly-6-related protein required for olfaction.
TL;DR: It is shown that residual responses to high concentrations of AWC-sensed odors are caused by the ability of other olfactory neurons (the AWA neurons) to be recruited at high odor concentrations.
Journal ArticleDOI
Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development
Gabriella Minchiotti,Silvia Parisi,Giovanna L. Liguori,Massimo Signore,Gabriella Lania,Eileen D. Adamson,C. T. Lago,M. Graziella Persico +7 more
TL;DR: It is suggested that presentation of Cripto on the cell surface via a GPI-linkage is important in determining the spatial specificity of cell-cell interactions that play a critical role in the early patterning of the embryo.
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Current approaches and perspectives in the therapy of medullary thyroid carcinoma.
Giovanni Vitale,Michele Caraglia,Antonio Ciccarelli,Gelsy Lupoli,Alberto Abbruzzese,Pierosandro Tagliaferri,Giovanni Lupoli +6 more
TL;DR: Medullary thyroid carcinoma is a neuroendocrine tumor derived from parafollicular cells and surgery is the most important treatment for MTC.
References
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Antibodies: A Laboratory Manual
Ed Harlow,David P. Lane +1 more
TL;DR: A second edition of Antibodies: A Laboratory Manual is being published in September 2013, Revised, extended and updated by Edward Greenfield of the Dana-Farber Cancer Center, the material has been recast with extensive new information and new chapters have been added.
Journal ArticleDOI
Improved tools for biological sequence comparison.
TL;DR: Three computer programs for comparisons of protein and DNA sequences can be used to search sequence data bases, evaluate similarity scores, and identify periodic structures based on local sequence similarity.
Journal ArticleDOI
Signal transduction by receptors with tyrosine kinase activity
Axel Ullrich,Joseph Schlessinger +1 more
TL;DR: Cet article synthese montre comment des recepteurs membranaires a activite tyrosine kinase peuvent etre impliques dans la transduction and notamment jouent le role de signal de the transduction.
Journal ArticleDOI
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
TL;DR: 5'-Noncoding sequences have been compiled from 699 vertebrate mRNAs and GCCA/GCCATGG emerges as the consensus sequence for initiation of translation in vertebrates.
Journal ArticleDOI
A new method for predicting signal sequence cleavage sites.
TL;DR: A new method for identifying secretory signal sequences and for predicting the site of cleavage between a signal sequence and the mature exported protein is described.
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