GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF
Shuqian Jing,Duanzhi Wen,Yanbin Yu,Paige Holst,Yi Luo,Mei Fang,Rami Tamir,Laarni Antonio,Zheng Hu,Rod Cupples,Jean-Claude Louis,Sylvia Hu,Bruce W. Altrock,Gary M. Fox +13 more
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TLDR
In this paper, the expression cloning and characterization of GDNFR-α, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF), was reported.About:
This article is published in Cell.The article was published on 1996-06-28 and is currently open access. It has received 1164 citations till now. The article focuses on the topics: Glial cell line-derived neurotrophic factor & GDNF family of ligands.read more
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Regeneration of entorhinal fibers in mouse slice cultures is age dependent and can be stimulated by NT-4, GDNF, and modulators of G-proteins and protein kinase C.
TL;DR: The findings indicate that the application of neurotrophic factors and the modulation of intracellular signal transduction pathways could be useful strategies to enhance axonal regeneration in a complex microenvironment.
Journal ArticleDOI
The significance of TNFAIP8 in prostate cancer response to radiation and docetaxel and disease recurrence.
Chuanbo Zhang,Bhaskar V. S. Kallakury,Jeffrey S. Ross,Rajshree R. Mewani,Christine E. Sheehan,Isamu Sakabe,George Luta,Deepak Kumar,Sivaramakrishna Yadavalli,Joshua Starr,Taduru Sreenath,Shiv Srivastava,Harvey B. Pollard,Ofer Eidelman,Meera Srivastava,Usha Kasid +15 more
TL;DR: It is demonstrated that TNFAIP8 expression is induced by androgen in hormone‐responsive LNCaP prostate cancer cells, and a potential relationship of the nuclear trafficking of TNFAip8 with adverse outcomes in a subset of prostate cancer patients is indicated.
Journal ArticleDOI
Neuroprotective utility and neurotrophic action of neurturin in postnatal motor neurons: comparison with GDNF and persephin.
TL;DR: Neurturin, like GDNF, increases the choline acetyltransferase activity of normal postnatal motor neurons, induces neurite outgrowth in spinal cord, and potently protects motor neurons from chronic glutamate-mediated degeneration.
Journal ArticleDOI
Spermatogonial stem cell markers and niche in equids.
Guilherme M.J. Costa,Gleide F. Avelar,José V. Rezende-Neto,Paulo Henrique Almeida Campos-Junior,Samyra M.S.N. Lacerda,Bruno Santos Cândido de Andrade,Ralph Gruppi Thomé,Marie Claude Hofmann,Luiz R. França +8 more
TL;DR: The findings strongly suggest that in stallions these cells were preferentially located in the areas facing the interstitium, particularly those nearby blood vessels, which suggests that the molecular mechanisms that maintain the niche and Aund/SSCs physiology are conserved among mammals.
Journal ArticleDOI
Glial-derived neurotrophic factor rescues calbindin-D28k-immunoreactive neurons in alcohol-treated cerebellar explant cultures.
TL;DR: The results suggest that glial-derived neurotrophic factor prevents ethanol-associated Purkinje cell loss, and concurrent administration of GDNF led to a significant rescue of calbindin-D28k-immunoreactive cells.
References
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Book
Antibodies: A Laboratory Manual
Ed Harlow,David P. Lane +1 more
TL;DR: A second edition of Antibodies: A Laboratory Manual is being published in September 2013, Revised, extended and updated by Edward Greenfield of the Dana-Farber Cancer Center, the material has been recast with extensive new information and new chapters have been added.
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Improved tools for biological sequence comparison.
TL;DR: Three computer programs for comparisons of protein and DNA sequences can be used to search sequence data bases, evaluate similarity scores, and identify periodic structures based on local sequence similarity.
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Signal transduction by receptors with tyrosine kinase activity
Axel Ullrich,Joseph Schlessinger +1 more
TL;DR: Cet article synthese montre comment des recepteurs membranaires a activite tyrosine kinase peuvent etre impliques dans la transduction and notamment jouent le role de signal de the transduction.
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An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
TL;DR: 5'-Noncoding sequences have been compiled from 699 vertebrate mRNAs and GCCA/GCCATGG emerges as the consensus sequence for initiation of translation in vertebrates.
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A new method for predicting signal sequence cleavage sites.
TL;DR: A new method for identifying secretory signal sequences and for predicting the site of cleavage between a signal sequence and the mature exported protein is described.
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