GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF
Shuqian Jing,Duanzhi Wen,Yanbin Yu,Paige Holst,Yi Luo,Mei Fang,Rami Tamir,Laarni Antonio,Zheng Hu,Rod Cupples,Jean-Claude Louis,Sylvia Hu,Bruce W. Altrock,Gary M. Fox +13 more
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TLDR
In this paper, the expression cloning and characterization of GDNFR-α, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF), was reported.About:
This article is published in Cell.The article was published on 1996-06-28 and is currently open access. It has received 1164 citations till now. The article focuses on the topics: Glial cell line-derived neurotrophic factor & GDNF family of ligands.read more
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Journal ArticleDOI
Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity.
Fredric P. Manfredsson,Nihal Tümer,Nihal Tümer,Benedek Erdos,Benedek Erdos,Tessa Landa,Tessa Landa,Christopher S. Broxson,Christopher S. Broxson,Layla F Sullivan,Aaron Rising,Kevin D. Foust,Yi Zhang,Yi Zhang,Nicholas Muzyczka,Oleg S. Gorbatyuk,Philip J. Scarpace,Philip J. Scarpace,Ronald J. Mandel +18 more
TL;DR: Nigrostriatal GDNF overexpression resulted in significantly greater weight loss than rats treated in hypothalamus and activation of phosphorylated extracellular signal-regulated kinase (p-ERK) in a small population of corticotrophin-releasing factor neurons located specifically in the medial parvocellullar division of the paraventricular nucleus of the hypothalamus likely accounted for the observed metabolic effects leading to weight loss in obese rats.
Journal Article
Effect of GDNF on neuroblast proliferation and photoreceptor survival: additive protection with docosahexaenoic acid.
TL;DR: Results show that GDNF stimulated the cell cycle progression, leading to neuroblast proliferation at early stages of development, and delayed the onset of apoptosis later on, improving differentiation and acting as a trophic factor for photoreceptors.
Journal ArticleDOI
Growth and guidance cues for regenerating axons: where have they gone?
Paulo D. Koeberle,Mathias Bähr +1 more
TL;DR: Current knowledge with respect to the response of adult CNS neurons to axonal injury, interventions for enhancing the survival and regeneration of injured neurons, and the expression of developmental axon guidance cues in the injured mature CNS are addressed, with specific focus on the retino-tectal projection.
Book ChapterDOI
Mechanism and Function of Signaling by the TGFβ Superfamily
TL;DR: This review will focus on recent developments in the understanding of TGFβ signaling and on the multiple roles these factors play in controlling inductive interactions and patterning during development.
Journal ArticleDOI
Neuroprotective Mechanism of Glial Cell Line-Derived Neurotrophic Factor in Mesencephalic Neurons
Hideyuki Sawada,Masakazu Ibi,Takeshi Kihara,Makoto Urushitani,Miki Nakanishi,Akinori Akaike,Shun Shimohama +6 more
TL;DR: Findings indicate that GDNF has no effect on necrosis but exerts protection against apoptosis by activation of phosphatidylinositol 3‐kinase and the subsequent up‐regulation of Bcl‐2 and BCl‐x, which suppresses accumulation of oxygen radicals followed by caspase‐3 activation.
References
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Book
Antibodies: A Laboratory Manual
Ed Harlow,David P. Lane +1 more
TL;DR: A second edition of Antibodies: A Laboratory Manual is being published in September 2013, Revised, extended and updated by Edward Greenfield of the Dana-Farber Cancer Center, the material has been recast with extensive new information and new chapters have been added.
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Improved tools for biological sequence comparison.
TL;DR: Three computer programs for comparisons of protein and DNA sequences can be used to search sequence data bases, evaluate similarity scores, and identify periodic structures based on local sequence similarity.
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Signal transduction by receptors with tyrosine kinase activity
Axel Ullrich,Joseph Schlessinger +1 more
TL;DR: Cet article synthese montre comment des recepteurs membranaires a activite tyrosine kinase peuvent etre impliques dans la transduction and notamment jouent le role de signal de the transduction.
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An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
TL;DR: 5'-Noncoding sequences have been compiled from 699 vertebrate mRNAs and GCCA/GCCATGG emerges as the consensus sequence for initiation of translation in vertebrates.
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A new method for predicting signal sequence cleavage sites.
TL;DR: A new method for identifying secretory signal sequences and for predicting the site of cleavage between a signal sequence and the mature exported protein is described.
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Characterization of a multicomponent receptor for GDNF
James J.S. Treanor,Laurie J. Goodman,Frederic J. de Sauvage,Donna M. Stone,Kristian Todd Poulsen,Claus D. Beck,Christa L. Gray,Mark Armanini,Richard A. Pollock,Franz Hefti,Heidi S. Phillips,Audry Goddard,Mark W. Moore,Anna Buj-Bello,Alun M. Davies,Naoya Asai,Masahide Takahashi,Richard Vandlen,Christopher E. Henderson,Arnon Rosenthal +19 more