Genetic Engineering of Mesenchymal Stem Cells and Its Application in Human Disease Therapy
TLDR
The current understanding of the use of genetically engineered mesenchymal stem cells in human disease therapy with emphasis on genetic modifications aimed to improve survival, homing, angiogenesis, and heart function after myocardial infarction is presented.Abstract:
The use of stem cells for tissue regeneration and repair is advancing both at the bench and bedside. Stem cells isolated from bone marrow are currently being tested for their therapeutic potential in a variety of clinical conditions including cardiovascular injury, kidney failure, cancer, and neurological and bone disorders. Despite the advantages, stem cell therapy is still limited by low survival, engraftment, and homing to damage area as well as inefficiencies in differentiating into fully functional tissues. Genetic engineering of mesenchymal stem cells is being explored as a means to circumvent some of these problems. This review presents the current understanding of the use of genetically engineered mesenchymal stem cells in human disease therapy with emphasis on genetic modifications aimed to improve survival, homing, angiogenesis, and heart function after myocardial infarction. Advancements in other disease areas are also discussed.read more
Citations
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Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology
TL;DR: The data suggest the existence of a tissue microenvironment where stem cell factors influence cell survival, inflammation, angiogenesis, repair, and regeneration in a temporal and spatial manner.
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Engineering mesenchymal stem cells for regenerative medicine and drug delivery
TL;DR: The advanced techniques of engineering MSC are highlighted, their promise and the challenges of translation into clinical settings are described, and future perspectives on realizing their full potential for MSC-based therapy are suggested.
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A revealing review of mesenchymal stem cells therapy, clinical perspectives and Modification strategies
TL;DR: Recent research findings of the clinical applications and therapeutic potential of this cell type, MSCs' mechanisms of therapy, strategies to improve their therapeutic potentials such as manipulations and preconditioning, and potential/unexpected risks which should be considered as a prerequisite step before clinical use are focused on.
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Multifunctional Upconversion Nanoparticles for Dual‐Modal Imaging‐Guided Stem Cell Therapy under Remote Magnetic Control
TL;DR: It is discovered that after being labeled with MFNPs, mouse mesenchymal stem cells are able to maintain their viability and differentiation ability and a remarkably improved tissue repair effect is observed as the result of magnetically induced accumulation of stem cells in the wound site.
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Effects on Proliferation and Differentiation of Multipotent Bone Marrow Stromal Cells Engineered to Express Growth Factors for Combined Cell and Gene Therapy
TL;DR: Effects of overexpressing the growth factors, such as basic fibroblast growth factor (bFGF), platelet derived growth factor B (PDGF‐BB), transforming growth factor β1 (TGF‐β1), and vascular endothelial growth factors (VEGF), in human bone marrow‐derived MSCs are shown.
References
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