Journal ArticleDOI
Givinostat as metabolic enhancer reverting mitochondrial biogenesis deficit in Duchenne Muscular Dystrophy.
Matteo Giovarelli,Silvia Zecchini,Giorgia Catarinella,Claudia Moscheni,Patrizia Sartori,Cecilia Barbieri,Paulina Roux-Biejat,Alessandra Napoli,Chiara Vantaggiato,Davide Cervia,Cristiana Perrotta,Emilio Clementi,Emilio Clementi,Lucia Latella,Clara De Palma +14 more
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TLDR
In this paper, Givinostat was shown to positively modify the epigenetic profile of peroxisome proliferator-activated receptor-gamma coactivator 1 α (PGC-1α) promoter, sustaining mitochondrial biogenesis and oxidative fiber type switch.About:
This article is published in Pharmacological Research.The article was published on 2021-08-01. It has received 12 citations till now. The article focuses on the topics: Mitochondrial biogenesis & Duchenne muscular dystrophy.read more
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Acid Sphingomyelinase Controls Early Phases of Skeletal Muscle Regeneration by Shaping the Macrophage Phenotype
Paulina Roux-Biejat,Marco Coazzoli,Pasquale Marrazzo,Silvia Zecchini,Ilaria Di Renzo,Cecilia Prata,Alessandra Napoli,Claudia Moscheni,Matteo Giovarelli,Maria Cristina Barbalace,Elisabetta Catalani,Maria Teresa Bassi,Clara De Palma,Davide Cervia,Marco Malaguti,Silvana Hrelia,Emilio Clementi,Cristiana Perrotta +17 more
TL;DR: In this article, acid sphingomyelinase (ASMase) was found to be activated after skeletal muscle injury induced in vivo by the injection of cardiotoxin, and the role of ASMase in regulating immune response during muscle regeneration/repair was investigated.
Journal ArticleDOI
Research progress in drug therapy of juvenile idiopathic arthritis
TL;DR: The application of biological agents in JIA showed good efficacy and safety, bringing unprecedented experience to children and adolescents with JIA, and the application of biologic agents in the treatment of JIA will be more and more common.
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The Role of Mitochondria in Mediation of Skeletal Muscle Repair
TL;DR: In this paper , the role of mitochondria in skeletal muscle myogenesis/regeneration and repair is discussed as a means for enhancing muscle regeneration. But, the role in muscle repair likely extends beyond the production of ATP and mitochondria could provide potentially important regulatory signaling to muscle stem cells during repair from injury.
Journal ArticleDOI
RACK1 is evolutionary conserved in satellite stem cell activation and adult skeletal muscle regeneration
Elisabetta Catalani,Silvia Zecchini,Matteo Giovarelli,Agnese Cherubini,Simona Del Quondam,Kashi Brunetti,Federica Silvestri,Paulina Roux-Biejat,Alessandra Napoli,Silvia Rosanna Casati,Marcello Ceci,Nicla Romano,Silvia Bongiorni,Giorgio Prantera,Emilio Clementi,Cristiana Perrotta,Clara De Palma,Davide Cervia +17 more
TL;DR: In this paper , the Receptor for Activated C-Kinase 1 (RACK1) was found to be important for skeletal muscle regeneration in both mouse and fruit fly.
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Danggui Buxue decoction ameliorates mitochondrial biogenesis and cognitive deficits through upregulating histone H4 lysine 12 acetylation in APP/PS1 mice.
Gaoshang Chai,Juan Gong,Jiajun Wu,Dong-Dong Jia,Xiaorun Zhai,Hong-xu Sun,Yunjuan Nie,Peng Zhao,Yi Xu +8 more
TL;DR: Wang et al. as mentioned in this paper showed that DBD could effectively attenuate memory impairments and enhance long-term potentiation (LTP) with concurrent increased expression of memory-associated proteins.
References
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Journal ArticleDOI
Metabolic control through the PGC-1 family of transcription coactivators.
TL;DR: This work has shown that the PGC-1 coactivators play a critical role in the maintenance of glucose, lipid, and energy homeostasis and are likely involved in the pathogenic conditions such as obesity, diabetes, neurodegeneration, and cardiomyopathy.
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The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
Laurent Mouchiroud,Riekelt H. Houtkooper,Norman Moullan,Elena Katsyuba,Dongryeol Ryu,Carles Cantó,Adrienne Mottis,Young Suk Jo,Mohan Viswanathan,Kristina Schoonjans,Leonard Guarente,Johan Auwerx +11 more
TL;DR: The data suggest that augmenting mitochondrial stress signaling through the modulation of NAD(+) levels may be a target to improve mitochondrial function and prevent or treat age-associated decline.
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Transcriptional Control of Mitochondrial Biogenesis and Function
TL;DR: Characterization of the transcriptional mechanisms that regulate mitochondrial biogenesis and function can offer insights into possible therapeutic interventions aimed at modulating mitochondrial function.
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Expression Profiling in the Muscular Dystrophies Identification of Novel Aspects of Molecular Pathophysiology
TL;DR: It is hypothesize that the abnormal Ca2+ influx in dystrophin- and α-sarcoglycan–deficient myofibers leads to altered developmental programming of developing and regenerating my ofibers, and that primary genetic defects can be identified by a reduction in the corresponding RNA.
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Animal models of Duchenne muscular dystrophy: From basic mechanisms to gene therapy
TL;DR: The field has reached the stage at which the results in mdx mice can be validated and scaled-up in symptomatic large animals, and the canine DMD (cDMD) model will be excellent for these studies.