Journal ArticleDOI
Transcriptional Control of Mitochondrial Biogenesis and Function
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TLDR
Characterization of the transcriptional mechanisms that regulate mitochondrial biogenesis and function can offer insights into possible therapeutic interventions aimed at modulating mitochondrial function.Abstract:
Mitochondria play central roles in energy homeostasis, metabolism, signaling, and apoptosis. Accordingly, the abundance, morphology, and functional properties of mitochondria are finely tuned to meet cellspecific energetic, metabolic, and signaling demands. This tuning is largely achieved at the level of transcriptional regulation. A highly interconnected network of transcription factors regulates a broad set of nuclear genes encoding mitochondrial proteins, including those that control replication and transcription of the mitochondrial genome. The same transcriptional network senses cues relaying cellular energy status, nutrient availability, and the physiological state of the organism and enables short- and long-term adaptive responses, resulting in adjustments to mitochondrial function and mitochondrial biogenesis. Mitochondrial dysfunction is associated with many human diseases. Characterization of the transcriptional mechanisms that regulate mitochondrial biogenesis and function can offer insights into possible therapeutic interventions aimed at modulating mitochondrial function.read more
Citations
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Journal ArticleDOI
Mitochondrial dysfunction and oxidative stress in metabolic disorders — A step towards mitochondria based therapeutic strategies
TL;DR: The purpose of the article is to highlight the recent progress on the mitochondrial role in metabolic syndromes and also summarize the progress of mitochondria-targeted molecules as therapeutic targets to treat metabolic Syndromes.
Journal ArticleDOI
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
Guenter Haemmerle,Tarek Moustafa,Gerald Woelkart,Sabrina Büttner,Albrecht Schmidt,Tineke van de Weijer,Matthijs K. C. Hesselink,Doris Jaeger,Petra C. Kienesberger,Kathrin A. Zierler,Renate Schreiber,Thomas O. Eichmann,Dagmar Kolb,Petra Kotzbeck,Martina Schweiger,Manju Kumari,Sandra Eder,Gabriele Schoiswohl,Nuttaporn Wongsiriroj,Nina M. Pollak,Franz P.W. Radner,Karina Preiss-Landl,Thomas Kolbe,Thomas Rülicke,Burkert Pieske,Michael Trauner,Achim Lass,Robert Zimmermann,Gerald Hoefler,Saverio Cinti,Erin E. Kershaw,Patrick Schrauwen,Frank Madeo,Bernd Mayer,Rudolf Zechner +34 more
TL;DR: Reconstituting normal PPAR target gene expression by pharmacological treatment of Atgl-deficient mice with PPAR-α agonists completely reverses the mitochondrial defects, restores normal heart function and prevents premature death.
Journal ArticleDOI
Redox regulation of mitochondrial function.
Diane E. Handy,Joseph Loscalzo +1 more
TL;DR: This review examines the regulation of cellular ROS, their modes of production and removal, and the redox-sensitive targets that are modified by their flux and the role of mitochondria in modulating these pathways.
Journal ArticleDOI
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes.
Federica Zatterale,Michele Longo,Michele Longo,Jamal Naderi,Gregory Alexander Raciti,Gregory Alexander Raciti,Antonella Desiderio,Antonella Desiderio,Claudia Miele,Claudia Miele,Francesco Beguinot,Francesco Beguinot +11 more
TL;DR: The molecular mechanisms responsible for the obesity-induced adipose tissue inflammation and progression toward obesity-associated comorbidities are summarized and the current therapeutic strategies are highlighted.
Journal ArticleDOI
Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction
Afshan N. Malik,Anna Czajka +1 more
TL;DR: Development of robust and reproducible methodology is needed to test the hypothesis that MtDNA content in body fluids is biomarker of mitochondrial dysfunction, as well as in tumour and normal tissue samples.
References
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Journal ArticleDOI
Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1
Zhidan Wu,Pere Puigserver,Ulf Andersson,Chen-Yu Zhang,Guillaume Adelmant,Vamsi K. Mootha,Amy E Troy,Saverio Cinti,Bradford B. Lowell,Richard C. Scarpulla,Bruce M. Spiegelman +10 more
TL;DR: PGC-1, a cold-inducible coactivator of nuclear receptors, stimulates mitochondrial biogenesis and respiration in muscle cells through an induction of uncoupling protein 2 (UCP-2) and through regulation of the nuclear respiratory factors (NRFs).
Journal ArticleDOI
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.
Marie Lagouge,Carmen Argmann,Zachary Gerhart-Hines,Hamid Meziane,Carles Lerin,Frédéric N. Daussin,Nadia Messadeq,Jill C. Milne,Philip D. Lambert,Peter J. Elliott,Bernard Geny,Markku Laakso,Pere Puigserver,Johan Auwerx +13 more
TL;DR: RSV's effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in P GC-1alpha acetylation and an increase in PGC-1 alpha activity.
Journal ArticleDOI
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.
Pere Puigserver,Zhidan Wu,Cheol Won Park,Reed A. Graves,Margaret E. Wright,Bruce M. Spiegelman +5 more
TL;DR: Results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis.
Journal ArticleDOI
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Jiandie D. Lin,Hai Wu,Paul T. Tarr,Chen-Yu Zhang,Zhidan Wu,Olivier Boss,Laura F. Michael,Pere Puigserver,Elji Isotani,Eric N. Olson,Bradford B. Lowell,Rhonda S Bassel-Duby,Bruce M. Spiegelman +12 more
TL;DR: Using fibre-type-specific promoters, it is shown in cultured muscle cells that PGC-1α activates transcription in cooperation with Mef2 proteins and serves as a target for calcineurin signalling, which has been implicated in slow fibre gene expression.
Journal ArticleDOI
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
TL;DR: The data indicate that AMPK phosphorylation of PGC-1α initiates many of the important gene regulatory functions of AMPK in skeletal muscle.