Journal ArticleDOI
Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1.
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TLDR
Findings support the role of circRNA in CRC pathogenesis by suggesting that hsa_circ_0020397 can regulate CRC cell viability, apoptosis and invasion by promoting the expression of miR‐138 target genes.About:
This article is published in Cell Biology International.The article was published on 2017-09-01. It has received 193 citations till now.read more
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Circular RNA: A potential diagnostic, prognostic, and therapeutic biomarker for human triple-negative breast cancer
TL;DR: In this article, the authors reviewed the potential of circRNAs as a diagnostic, prognostic, and therapeutic biomarker for triple negative breast cancer (TNBC) in young women.
Journal ArticleDOI
Decreased expression of circ_0020397 in intracranial aneurysms may be contributing to decreased vascular smooth muscle cell proliferation via increased expression of miR-138 and subsequent decreased KDR expression.
TL;DR: It is demonstrated that decreased expression of circRNA_0020397 in IA may contribute to the decreased VSMC proliferation via increasing miR-138 expression and subsequently decreasing KDR expression.
Journal ArticleDOI
CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance
TL;DR: Findings indicated that hsa_circ_0109291 correlated with the progression of OSCC and might be a new therapeutic target for the treatment of OS CC.
Journal ArticleDOI
Overexpression of circ-0067934 is associated with increased cellular proliferation and the prognosis of non-small cell lung cancer.
TL;DR: The results indicated that circ-0067934 may be a predictive marker for the prognosis of NSCLC and a target for the treatment of the disease.
Journal ArticleDOI
Circular RNA Expression Profiles and the Pro-tumorigenic Function of CircRNA_10156 in Hepatitis B Virus-Related Liver Cancer.
TL;DR: In this paper, the authors used the high-throughput RNA sequencing technology in conjunction with bioinformatics tools to profile circRNA expression in patients with HBV-related liver cancer.
References
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Cancer statistics, 2016
TL;DR: Overall cancer incidence trends are stable in women, but declining by 3.1% per year in men, much of which is because of recent rapid declines in prostate cancer diagnoses, and brain cancer has surpassed leukemia as the leading cause of cancer death among children and adolescents.
Journal ArticleDOI
Cancer statistics in China, 2015
Wanqing Chen,Rongshou Zheng,Peter D. Baade,Siwei Zhang,Hongmei Zeng,Freddie Bray,Ahmedin Jemal,Xue Qin Yu,Jie He +8 more
TL;DR: Many of the estimated cancer cases and deaths can be prevented through reducing the prevalence of risk factors, while increasing the effectiveness of clinical care delivery, particularly for those living in rural areas and in disadvantaged populations.
Journal ArticleDOI
Natural RNA circles function as efficient microRNA sponges
Thomas B. Hansen,Trine I. Jensen,Bettina Hjelm Clausen,Jesper B. Bramsen,Bente Finsen,Christian Kroun Damgaard,Jørgen Kjems +6 more
TL;DR: This study serves as the first functional analysis of a naturally expressed circular RNA, ciRS-7, which contains more than 70 selectively conserved miRNA target sites, and is highly and widely associated with Argonaute proteins in a miR-7-dependent manner.
Journal ArticleDOI
Atezolizumab Versus Docetaxel for Patients With Previously Treated Non-Small-Cell Lung Cancer (POPLAR): A Multicentre, Open-Label, Phase 2 Randomised Controlled Trial
Louis Fehrenbacher,Alexander I. Spira,Marcus Ballinger,Marcin Kowanetz,Johan Vansteenkiste,Julien Mazieres,Keunchil Park,David J. Smith,A. Artal-Cortes,Conrad R. Lewanski,Fadi Braiteh,Daniel Waterkamp,Pei He,Wei Zou,Daniel S. Chen,Jing Yi,Alan Sandler,Achim Rittmeyer +17 more
TL;DR: This open-label, phase 2 randomised controlled trial assessed efficacy and safety of atezolizumab versus docetaxel in previously treated NSCLC, analysed by PD-L1 expression levels on tumours and tumour-infiltrating immune cells and in the intention-to-treat population.
Journal ArticleDOI
Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs
Qiupeng Zheng,Chunyang Bao,Weijie Guo,Weijie Guo,Shuyi Li,Shuyi Li,Jie Chen,Bing Chen,Yanting Luo,Dongbin Lyu,Yan Li,Guohai Shi,Linhui Liang,Jianren Gu,Xianghuo He,Shenglin Huang +15 more
TL;DR: The results provide evidence that circular RNA produced from precursor mRNA may have a regulatory role in human cells and characterize one abundant circRNA derived from Exon2 of the HIPK3 gene, termed circHIPK3.