Journal ArticleDOI
Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1.
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TLDR
Findings support the role of circRNA in CRC pathogenesis by suggesting that hsa_circ_0020397 can regulate CRC cell viability, apoptosis and invasion by promoting the expression of miR‐138 target genes.About:
This article is published in Cell Biology International.The article was published on 2017-09-01. It has received 193 citations till now.read more
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Dissertation
Investigation of the roles of circular RNA circZNF609 during colorectal cancer progression
TL;DR: This study has identified several circRNAs differentially expressed in primary tumors and liver metastases suggesting a role of these RNAs in tumor progression, and confirmed that circZNF609 can function as oncogene to promote colorectal cancer progression.
Journal ArticleDOI
Dysregulation of global circular RNA abundance regulated by spliceosomes predicts prognosis in hepatocellular carcinoma
Lei He,Liman Qiu,Feng Chen,Ting Chen,Fang Peng,Zhenli Li,Xiuqing Dong,Zhixiong Cai,Yuanchang Fang,Hengkai Chen,Geng Chen,Xiaolong Liu +11 more
TL;DR: In this paper , the global abundance of circRNAs and their involvement in hepatocellular carcinoma (HCC) development have not been fully explored, and the correlation between the global circRNA abundance and the infiltration level of CD8+ T cells was explored by immunohistochemical assays.
Journal ArticleDOI
Significance of circRNAs as biomarkers for systemic lupus erythematosus: a systematic review and meta-analysis
TL;DR: Meta-analysis of pooled data indicated a moderate accuracy of circRNAs in diagnosing SLE, and the exact diagnostic value of circRNA expression levels and the mechanisms of interaction between circ RNAs and their parental genes should be confirmed in further studies.
Journal ArticleDOI
Review of novel functions and implications of circular RNAs in hepatocellular carcinoma
TL;DR: The role of Circular RNAs in the development and progression of hepatocellular carcinoma (HCC) was discussed in this article , where the authors highlighted the implications of circRNAs as potential biomarkers and therapeutic targets for HCC.
Journal ArticleDOI
CircRNAs in tumor immunity and immunotherapy: Perspectives from innate and adaptive immunity.
TL;DR: The role of Circular RNAs in tumor immunotherapy has been discussed in this article , where the authors summarize the role of circRNAs on tumor immunity from the viewpoint of innate and adaptive immunity.
References
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Journal ArticleDOI
Cancer statistics, 2016
TL;DR: Overall cancer incidence trends are stable in women, but declining by 3.1% per year in men, much of which is because of recent rapid declines in prostate cancer diagnoses, and brain cancer has surpassed leukemia as the leading cause of cancer death among children and adolescents.
Journal ArticleDOI
Cancer statistics in China, 2015
Wanqing Chen,Rongshou Zheng,Peter D. Baade,Siwei Zhang,Hongmei Zeng,Freddie Bray,Ahmedin Jemal,Xue Qin Yu,Jie He +8 more
TL;DR: Many of the estimated cancer cases and deaths can be prevented through reducing the prevalence of risk factors, while increasing the effectiveness of clinical care delivery, particularly for those living in rural areas and in disadvantaged populations.
Journal ArticleDOI
Natural RNA circles function as efficient microRNA sponges
Thomas B. Hansen,Trine I. Jensen,Bettina Hjelm Clausen,Jesper B. Bramsen,Bente Finsen,Christian Kroun Damgaard,Jørgen Kjems +6 more
TL;DR: This study serves as the first functional analysis of a naturally expressed circular RNA, ciRS-7, which contains more than 70 selectively conserved miRNA target sites, and is highly and widely associated with Argonaute proteins in a miR-7-dependent manner.
Journal ArticleDOI
Atezolizumab Versus Docetaxel for Patients With Previously Treated Non-Small-Cell Lung Cancer (POPLAR): A Multicentre, Open-Label, Phase 2 Randomised Controlled Trial
Louis Fehrenbacher,Alexander I. Spira,Marcus Ballinger,Marcin Kowanetz,Johan Vansteenkiste,Julien Mazieres,Keunchil Park,David J. Smith,A. Artal-Cortes,Conrad R. Lewanski,Fadi Braiteh,Daniel Waterkamp,Pei He,Wei Zou,Daniel S. Chen,Jing Yi,Alan Sandler,Achim Rittmeyer +17 more
TL;DR: This open-label, phase 2 randomised controlled trial assessed efficacy and safety of atezolizumab versus docetaxel in previously treated NSCLC, analysed by PD-L1 expression levels on tumours and tumour-infiltrating immune cells and in the intention-to-treat population.
Journal ArticleDOI
Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs
Qiupeng Zheng,Chunyang Bao,Weijie Guo,Weijie Guo,Shuyi Li,Shuyi Li,Jie Chen,Bing Chen,Yanting Luo,Dongbin Lyu,Yan Li,Guohai Shi,Linhui Liang,Jianren Gu,Xianghuo He,Shenglin Huang +15 more
TL;DR: The results provide evidence that circular RNA produced from precursor mRNA may have a regulatory role in human cells and characterize one abundant circRNA derived from Exon2 of the HIPK3 gene, termed circHIPK3.