Journal ArticleDOI
Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1.
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TLDR
Findings support the role of circRNA in CRC pathogenesis by suggesting that hsa_circ_0020397 can regulate CRC cell viability, apoptosis and invasion by promoting the expression of miR‐138 target genes.About:
This article is published in Cell Biology International.The article was published on 2017-09-01. It has received 193 citations till now.read more
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A New Approach Based on Feature Selection of Light Gradient Boosting Machine and Transformer to Predict circRNA-Disease Associations
TL;DR: Wang et al. as mentioned in this paper proposed a method for predicting the circRNA-disease associations based on the feature selection using Light Gradient Boosting Machine (LightGBM) and a self-attention neural network-Transformer (LGFRCDA), which achieved a prediction accuracy of 95.44% for AUC (Area Under the receiver operating characteristic curve), which is 3.11% higher than the latest algorithms for the same dataset.
Journal ArticleDOI
Role of circular RNA and its delivery strategies to cancer - An overview.
TL;DR: Recently, there has been a huge increase in the interest of researchers in this group of molecules, which entailed a significant increase in state of knowledge about them, which in turn caused a dramatic change in their perception as mentioned in this paper .
Journal ArticleDOI
Different Roles of Apoptosis and Autophagy in the Development of Human Colorectal Cancer
TL;DR: In this paper, the authors elucidate the different roles of autophagy and apoptosis in human colorectal cancer development and identify the molecules involved, as well as the signals and the mechanisms behind it.
Journal ArticleDOI
[Role of circular RNAs in immune-related diseases].
Weijie Zhan,Tao Yan,Jiawen Gao,Min Yu Song,Ting Wang,Fei-lei Lin,Haiyu Zhou,Li Li,Chao Zhang +8 more
TL;DR: Current evidence has shown that circRNAs can be potentially used as excellent biomarkers for diagnosis, therapeutic effect evaluation, and prognostic assessment of a variety of diseases, and they may also provide effective therapeutic targets due to their stability and tissue and development-stage specificity.
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Exosomes-delivered PD-L1 siRNA and CTLA-4 siRNA protect against growth and tumor immune escape in colorectal cancer.
TL;DR: In this paper , exosomes containing PD-L1 siRNA and CTLA-4 siRNA were prepared and utilized to treat colorectal cancer (CRC) cells to evaluate their effects.
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Cancer statistics in China, 2015
Wanqing Chen,Rongshou Zheng,Peter D. Baade,Siwei Zhang,Hongmei Zeng,Freddie Bray,Ahmedin Jemal,Xue Qin Yu,Jie He +8 more
TL;DR: Many of the estimated cancer cases and deaths can be prevented through reducing the prevalence of risk factors, while increasing the effectiveness of clinical care delivery, particularly for those living in rural areas and in disadvantaged populations.
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Natural RNA circles function as efficient microRNA sponges
Thomas B. Hansen,Trine I. Jensen,Bettina Hjelm Clausen,Jesper B. Bramsen,Bente Finsen,Christian Kroun Damgaard,Jørgen Kjems +6 more
TL;DR: This study serves as the first functional analysis of a naturally expressed circular RNA, ciRS-7, which contains more than 70 selectively conserved miRNA target sites, and is highly and widely associated with Argonaute proteins in a miR-7-dependent manner.
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Atezolizumab Versus Docetaxel for Patients With Previously Treated Non-Small-Cell Lung Cancer (POPLAR): A Multicentre, Open-Label, Phase 2 Randomised Controlled Trial
Louis Fehrenbacher,Alexander I. Spira,Marcus Ballinger,Marcin Kowanetz,Johan Vansteenkiste,Julien Mazieres,Keunchil Park,David J. Smith,A. Artal-Cortes,Conrad R. Lewanski,Fadi Braiteh,Daniel Waterkamp,Pei He,Wei Zou,Daniel S. Chen,Jing Yi,Alan Sandler,Achim Rittmeyer +17 more
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Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs
Qiupeng Zheng,Chunyang Bao,Weijie Guo,Weijie Guo,Shuyi Li,Shuyi Li,Jie Chen,Bing Chen,Yanting Luo,Dongbin Lyu,Yan Li,Guohai Shi,Linhui Liang,Jianren Gu,Xianghuo He,Shenglin Huang +15 more
TL;DR: The results provide evidence that circular RNA produced from precursor mRNA may have a regulatory role in human cells and characterize one abundant circRNA derived from Exon2 of the HIPK3 gene, termed circHIPK3.