Journal ArticleDOI
Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1.
Reads0
Chats0
TLDR
Findings support the role of circRNA in CRC pathogenesis by suggesting that hsa_circ_0020397 can regulate CRC cell viability, apoptosis and invasion by promoting the expression of miR‐138 target genes.About:
This article is published in Cell Biology International.The article was published on 2017-09-01. It has received 193 citations till now.read more
Citations
More filters
Journal ArticleDOI
The expression profile and clinical significance of circRNA0003906 in colorectal cancer.
TL;DR: It was showed that circRNA0003906 expression level was dramatically downregulated in both CRC tissues and cell lines, and may be potentially involved in the colorectal cancerogenesis and serve as a potential biomarker for the diagnosis and treatment of CRC.
Journal ArticleDOI
CircRNA hsa_circ_0004585 as a potential biomarker for colorectal cancer
TL;DR: Hsa_circ_0004585 expression was significantly upregulated both in CRC patients tissue and peripheral blood, indicating the function of hsa_ circ_000 4585 in CRC carcinogenesis and metastasis, and could be a potential biomarker for diagnosis of CRC.
Journal ArticleDOI
Noncoding RNAs as potential mediators of resistance to cancer immunotherapy
TL;DR: The current state of knowledge implicating miRNAs and lncRNAs in regulating immune response against human cancer and their potential implications in resistance to cancer immunotherapy are presented, with main emphasis on immune checkpoints.
Journal ArticleDOI
Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer.
TL;DR: The epigenetic mechanisms through which lncRNAs regulate gene expression in cancer cells are discussed and the role of UCA1 in the regulation of cell cycle progression and its relation to chemoresistance in colorectal cancer cells is discussed.
Journal ArticleDOI
Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies.
Sabah Nisar,Ajaz A. Bhat,Mayank Singh,Thasni Karedath,Arshi Rizwan,Sheema Hashem,Puneet Bagga,Ravinder Reddy,Farrukh Jamal,Shahab Uddin,Gyan Chand,Davide Bedognetti,Wael El-Rifai,Michael P. Frenneaux,Muzafar A. Macha,Ikhlak Ahmed,Mohammad Haris,Mohammad Haris +17 more
TL;DR: In this paper, the properties, characterization, profiling, and diverse molecular mechanisms of circRNAs and their use as potential therapeutic targets in different human malignancies are discussed, including cancer and neurodegenerative disorders such as Alzheimer's and Parkinson's disease.
References
More filters
Journal ArticleDOI
Cancer statistics, 2016
TL;DR: Overall cancer incidence trends are stable in women, but declining by 3.1% per year in men, much of which is because of recent rapid declines in prostate cancer diagnoses, and brain cancer has surpassed leukemia as the leading cause of cancer death among children and adolescents.
Journal ArticleDOI
Cancer statistics in China, 2015
Wanqing Chen,Rongshou Zheng,Peter D. Baade,Siwei Zhang,Hongmei Zeng,Freddie Bray,Ahmedin Jemal,Xue Qin Yu,Jie He +8 more
TL;DR: Many of the estimated cancer cases and deaths can be prevented through reducing the prevalence of risk factors, while increasing the effectiveness of clinical care delivery, particularly for those living in rural areas and in disadvantaged populations.
Journal ArticleDOI
Natural RNA circles function as efficient microRNA sponges
Thomas B. Hansen,Trine I. Jensen,Bettina Hjelm Clausen,Jesper B. Bramsen,Bente Finsen,Christian Kroun Damgaard,Jørgen Kjems +6 more
TL;DR: This study serves as the first functional analysis of a naturally expressed circular RNA, ciRS-7, which contains more than 70 selectively conserved miRNA target sites, and is highly and widely associated with Argonaute proteins in a miR-7-dependent manner.
Journal ArticleDOI
Atezolizumab Versus Docetaxel for Patients With Previously Treated Non-Small-Cell Lung Cancer (POPLAR): A Multicentre, Open-Label, Phase 2 Randomised Controlled Trial
Louis Fehrenbacher,Alexander I. Spira,Marcus Ballinger,Marcin Kowanetz,Johan Vansteenkiste,Julien Mazieres,Keunchil Park,David J. Smith,A. Artal-Cortes,Conrad R. Lewanski,Fadi Braiteh,Daniel Waterkamp,Pei He,Wei Zou,Daniel S. Chen,Jing Yi,Alan Sandler,Achim Rittmeyer +17 more
TL;DR: This open-label, phase 2 randomised controlled trial assessed efficacy and safety of atezolizumab versus docetaxel in previously treated NSCLC, analysed by PD-L1 expression levels on tumours and tumour-infiltrating immune cells and in the intention-to-treat population.
Journal ArticleDOI
Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs
Qiupeng Zheng,Chunyang Bao,Weijie Guo,Weijie Guo,Shuyi Li,Shuyi Li,Jie Chen,Bing Chen,Yanting Luo,Dongbin Lyu,Yan Li,Guohai Shi,Linhui Liang,Jianren Gu,Xianghuo He,Shenglin Huang +15 more
TL;DR: The results provide evidence that circular RNA produced from precursor mRNA may have a regulatory role in human cells and characterize one abundant circRNA derived from Exon2 of the HIPK3 gene, termed circHIPK3.