Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
Nicolas de Roux,Emmanuelle Génin,Jean Claude Carel,Fumihiko Matsuda,Chaussain Jl,Edwin Milgrom +5 more
Reads0
Chats0
TLDR
The present study shows that loss of function of GPR54 is a cause of IHH, and it identifies GPR 54 and possibly KiSS1 protein-derived peptide as playing a major and previously unsuspected role in the physiology of the gonadotropic axis.Abstract:
Hypogonadotropic hypogonadism is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. In the absence of pituitary or hypothalamic anatomical lesions and of anosmia (Kallmann syndrome), hypogonadotropic hypogonadism is referred to as isolated hypogonadotropic hypogonadism (IHH). A limited number of IHH cases are due to loss-of-function mutations of the gonadotropin-releasing hormone receptor. To identify additional gene defects leading to IHH, a large consanguineous family with five affected siblings and with a normal gonadotropin-releasing hormone receptor coding sequence was studied. Homozygosity whole-genome mapping allowed the localization of a new locus within the short arm of chromosome 19 (19p13). Sequencing of several genes localized within this region showed that all affected siblings of the family carried a homozygous deletion of 155 nucleotides in the GPR54 gene. This deletion encompassed the splicing acceptor site of intron 4-exon 5 junction and part of exon 5. The deletion was absent or present on only one allele in unaffected family members. GPR54 has been initially identified as an orphan G protein-coupled receptor with 40% homology to galanin receptors. Recently, a 54-aa peptide derived from the KiSS1 protein was identified as a ligand of GPR54. The present study shows that loss of function of GPR54 is a cause of IHH, and it identifies GPR54 and possibly KiSS1 protein-derived peptide as playing a major and previously unsuspected role in the physiology of the gonadotropic axis.read more
Citations
More filters
Journal ArticleDOI
2-acylamino-4,6-diphenylpyridine derivatives as novel GPR54 antagonists with good brain exposure and in vivo efficacy for plasma LH level in male rats.
Toshitake Kobayashi,Satoshi Sasaki,Naoki Tomita,Seiji Fukui,Masaharu Nakayama,Atsushi Kiba,Masami Kusaka,Shin-ichi Matsumoto,Masashi Yamaguchi,Fumio Itoh,Atsuo Baba +10 more
TL;DR: 15a containing a piperazine group exhibited high affinity to human and rat GPR54, apparent antagonistic activity, and high brain exposure, which indicates the possibility of a small molecule G PR54 antagonist as a novel drug for sex-hormone dependent diseases.
Journal ArticleDOI
Molecular and Epigenetic Mechanism Regulating Hypothalamic Kiss1 Gene Expression in Mammals
Yoshihisa Uenoyama,Junko Tomikawa,Naoko Inoue,Teppei Goto,Shiori Minabe,Nahoko Ieda,Sho Nakamura,Youki Watanabe,Kana Ikegami,Fuko Matsuda,Satoshi Ohkura,Kei-ichiro Maeda,Hiroko Tsukamura +12 more
TL;DR: Data regarding DNA and histone modifications in the Kiss1 promoter region is compiled and provided to provide a hypothetic scheme of the molecular and epigenetic mechanism regulating Kiss1 gene expression in two populations of hypothalamic kisspeptin neurons, which govern puberty and subsequent reproductive performance via GnRH/gonadotropin secretion.
Journal ArticleDOI
ESR2 Is Essential for Gonadotropin-Induced Kiss1 Expression in Granulosa Cells
V. Praveen Chakravarthi,Vincentaben Khristi,Subhra Ghosh,Sireesha Yerrathota,Eddie Dai,Katherine F. Roby,Michael W. Wolfe,M.A. Karim Rumi +7 more
TL;DR: Gonadotropin-stimulated Kiss1 expression in granulosa cells is dependent on both the activation of ESR2 and the upregulation of AP-1, and gonadotropic factors could synergistically activate the Kiss1 promoter activity.
Journal ArticleDOI
Immunohistochemical expression pattern of metastasis suppressors KAI1 and KISS1 in endometriosis and normal endometrium
Anna Timologou,Menelaos Zafrakas,Menelaos Zafrakas,Grigorios Grimbizis,Dimosthenis Miliaras,Konstantinos Kotronis,Panayiotis Stamatopoulos,Basil C. Tarlatzis +7 more
TL;DR: KAI1 and KISS1 are implicated in the pathogenesis and maintenance of endometriosis and could be used as markers for early and minimally invasive detection of endometricriosis based on their differential protein expression pattern in the eutopic endometrium of patients with and without endometRIosis.
Book ChapterDOI
Neuroendocrine Control of Gonadotropin Secretion: Comparative Aspects
TL;DR: In this article, the similarities and differences among species in the neuroendocrine control of gonadotropin secretion are discussed, focusing on mice and rats, sheep, and primates.
References
More filters
Journal Article
Parametric and nonparametric linkage analysis: a unified multipoint approach.
TL;DR: It is shown that NPL is robust to uncertainty about mode of inheritance, is much more powerful than commonly used nonparametric methods, and loses little power relative to parametric linkage analysis, and appears to be the method of choice for pedigree studies of complex traits.
Journal ArticleDOI
A comprehensive genetic map of the human genome based on 5,264 microsatellites
Colette Dib,Sabine Fauré,Cécile Fizames,Delphine Samson,N. Drouot,Alain Vignal,P Millasseau,S Marc,Jamilé Hazan,Eric Seboun,Mark Lathrop,Gabor Gyapay,Jean Morissette,Jean Morissette,Jean Weissenbach +14 more
TL;DR: The last version of the Généthon human linkage map is reported, which consists of 5,264 short tandem repeat polymorphisms with a mean heterozygosity of 70%.
Journal ArticleDOI
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Masato Kotani,Michel Detheux,Ann Vandenbogaerde,David Communi,Jean-Marie Vanderwinden,Emmanuel Le Poul,Stéphane Brézillon,Richard Tyldesley,Nathalie Suarez-Huerta,Fabrice Vandeput,Cédric Blanpain,Serge N. Schiffmann,Gilbert Vassart,Marc Parmentier +13 more
TL;DR: Stimulation of oxytocin secretion after kisspeptin administration to rats confirmed this hypothesis that human GPR54 was highly expressed in placenta, pituitary, pancreas, and spinal cord, suggesting a role in the regulation of endocrine function.
Journal Article
Faster sequential genetic linkage computations.
TL;DR: A variety of algorithmic improvements are described, which synthesize biological principles with computer science techniques, to effectively restructure the time-consuming computations in genetic linkage analysis.
Journal ArticleDOI
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.
Tetsuya Ohtaki,Yasushi Shintani,Susumu Honda,Hirokazu Matsumoto,Akira Hori,Kimiko Kanehashi,Yasuko Terao,Satoshi Kumano,Yoshihiro Takatsu,Yasushi Masuda,Yoshihiro Ishibashi,Takuya Watanabe,Mari Asada,Takao Yamada,Masato Suenaga,Chieko Kitada,Satoshi Usuki,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Masahiko Fujino +20 more
TL;DR: It is shown that KiSS-1 encodes a carboxy-terminally amidated peptide with 54 amino-acid residues, which is isolated from human placenta as the endogenous ligand of an orphan G-protein-coupled receptor (hOT7T175) and named ‘metastin’.
Related Papers (5)
The GPR54 gene as a regulator of puberty
Stephanie B. Seminara,Sophie Messager,Emmanouella E. Chatzidaki,Rosemary R. Thresher,James S. Acierno,Jenna K. Shagoury,Yousef Bo-Abbas,Wendy Kuohung,Kristine M. Schwinof,Alan G. Hendrick,Dirk Zahn,John Dixon,Ursula B. Kaiser,Susan A. Slaugenhaupt,James F. Gusella,Stephen O'Rahilly,Mark Carlton,William F. Crowley,Samuel Aparicio,William H. Colledge +19 more
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.
Tetsuya Ohtaki,Yasushi Shintani,Susumu Honda,Hirokazu Matsumoto,Akira Hori,Kimiko Kanehashi,Yasuko Terao,Satoshi Kumano,Yoshihiro Takatsu,Yasushi Masuda,Yoshihiro Ishibashi,Takuya Watanabe,Mari Asada,Takao Yamada,Masato Suenaga,Chieko Kitada,Satoshi Usuki,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Masahiko Fujino +20 more