Immunogenicity and protective efficacy of inactivated SARS-CoV-2 vaccine candidate, BBV152 in rhesus macaques.
Pragya D Yadav,Raches Ella,Sanjay Kumar,Dilip R. Patil,Sreelekshmy Mohandas,Anita M. Shete,Krishna Mohan Vadrevu,Gaurav Bhati,Gajanan N. Sapkal,Himanshu Kaushal,Savita Patil,Rajlaxmi Jain,Gururaj Rao Deshpande,Nivedita Gupta,Kshitij Agarwal,M D Gokhale,Basavaraj Mathapati,Siddhanath Metkari,Chandrashekhar Mote,Dimpal A Nyayanit,Deepak Y. Patil,B. S. Sai Prasad,Annasaheb Suryawanshi,Manoj Kadam,Abhimanyu Kumar,Sachin Daigude,Sanjay Gopale,Triparna Majumdar,Deepak Mali,Prasad Sarkale,Shreekant Baradkar,Pranita Gawande,Yash Joshi,Sidharam Fulari,Hitesh Dighe,Sharda Sharma,Rashmi Gunjikar,Abhinendra Kumar,Kaumudi Kalele,V.K. Srinivas,Raman R. Gangakhedkar,Krishna Murthy Ella,Priya Abraham,Samiran Panda,Balram Bhargava +44 more
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TLDR
In this article, the authors developed and assessed the protective efficacy and immunogenicity of an inactivated SARS-CoV-2 vaccine in rhesus macaques, and the vaccine candidate BBV152 has completed Phase I/II (NCT04471519) clinical trials in India and is presently in phase III.Abstract:
The COVID-19 pandemic is a global health crisis that poses a great challenge to the public health system of affected countries. Safe and effective vaccines are needed to overcome this crisis. Here, we develop and assess the protective efficacy and immunogenicity of an inactivated SARS-CoV-2 vaccine in rhesus macaques. Twenty macaques were divided into four groups of five animals each. One group was administered a placebo, while three groups were immunized with three different vaccine candidates of BBV152 at 0 and 14 days. All the macaques were challenged with SARS-CoV-2 fourteen days after the second dose. The protective response was observed with increasing SARS-CoV-2 specific IgG and neutralizing antibody titers from 3rd-week post-immunization. Viral clearance was observed from bronchoalveolar lavage fluid, nasal swab, throat swab and lung tissues at 7 days post-infection in the vaccinated groups. No evidence of pneumonia was observed by histopathological examination in vaccinated groups, unlike the placebo group which exhibited interstitial pneumonia and localization of viral antigen in the alveolar epithelium and macrophages by immunohistochemistry. This vaccine candidate BBV152 has completed Phase I/II (NCT04471519) clinical trials in India and is presently in phase III, data of this study substantiates the immunogenicity and protective efficacy of the vaccine candidates.read more
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Efficacy, safety, and lot-to-lot immunogenicity of an inactivated SARS-CoV-2 vaccine (BBV152): interim results of a randomised, double-blind, controlled, phase 3 trial.
Raches Ella,Siddarth Reddy,William C. Blackwelder,Varsha Potdar,Pragya D Yadav,Vamshi Sarangi,Vinay Kumar Aileni,Suman Kanungo,Sanjay K Rai,P. Prabhakar Reddy,Savita Verma,Chandramani Singh,Sagar Vivek Redkar,Satyajit Mohapatra,Anil Pandey,Pajanivel Ranganadin,Raghavendra Gumashta,Manish Multani,Shameem Mohammad,Parul Bhatt,Laxmi Kumari,Gajanan Sapkal,Nivedita Gupta,Priya Abraham,Samiran Panda,Sai Prasad,Balram Bhargava,Krishna Murthy Ella,Krishna Mohan Vadrevu +28 more
TL;DR: In this article, the authors reported the clinical efficacy against COVID-19 infection of BBV152, a whole virion inactivated SARS-CoV-2 vaccine formulated with a toll-like receptor 7/8 agonist molecule adsorbed to alum (Algel-IMDG) in Indian adults.
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A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development
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Covid-19 vaccines and variants of concern: A review.
TL;DR: In this article, the most relevant mutations in the SARS-CoV-2 spike protein, discusses VE against VOCs, presents rare adverse events after Covid-19 vaccination and introduces some promising Covid19 vaccine candidates.
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COVID-19 Vaccines: A Review of the Safety and Efficacy of Current Clinical Trials
TL;DR: In this article, the authors reviewed the most recent data of 12 vaccines to evaluate their efficacy, safety profile and usage in various populations, and compared the protective efficacy and risks of vaccination is essential for the global control of COVID-19 through herd immunity.
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Understanding neutralising antibodies against SARS-CoV-2 and their implications in clinical practice.
TL;DR: In this paper, the authors discuss the current understanding of neutralizing antibodies and their implications in clinical practice and discuss the applications of neutralising antibodies in the clinical setting-from predictors of disease severity to serological testing to vaccinations, and finally in therapeutics such as convalescent plasma infusion.
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